Patents by Inventor John R. Gilbertson
John R. Gilbertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7876948Abstract: An imaging apparatus. The imaging apparatus may find an area in which a specimen is present, then focus on the specimen and capture images of the specimen during continuous stage motion.Type: GrantFiled: July 24, 2009Date of Patent: January 25, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: 7869641Abstract: A system for determining tissue locations on a slide.Type: GrantFiled: May 27, 2009Date of Patent: January 11, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser
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Publication number: 20100060729Abstract: An imaging apparatus. The imaging apparatus may find an area in which a specimen is present, then focus on the specimen and capture images of the specimen during continuous stage motion.Type: ApplicationFiled: July 24, 2009Publication date: March 11, 2010Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, JR.
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Publication number: 20100002918Abstract: A system for determining tissue locations on a slide.Type: ApplicationFiled: May 27, 2009Publication date: January 7, 2010Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser
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Patent number: 7421102Abstract: A system for determining tissue locations on a slide.Type: GrantFiled: September 6, 2005Date of Patent: September 2, 2008Assignee: Carl Zeiss MicroImaging AIS, Inc.Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Publication number: 20080123919Abstract: A system for determining tissue locations on a slide.Type: ApplicationFiled: October 31, 2007Publication date: May 29, 2008Inventors: Arthur W. Wetzel, John R. Gilbertson, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri
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Patent number: 7212660Abstract: Imaging apparatuses and methods that capture a low-resolution image of a slide, identify a region of interest, and capture a high-resolution image of the region of interest.Type: GrantFiled: October 26, 2005Date of Patent: May 1, 2007Assignee: Clarient, Inc.Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: 7155049Abstract: An imaging apparatus is disclosed. The imaging apparatus includes a motorized stage, a camera focussed relative to the stage, and a processor coupled to the camera. The processor contains instructions which, when executed by the processor, cause the processor to capture an image incident on the camera, convert the image into a plurality of pixels having a characteristic such as intensity, establish the characteristic for each pixel; and determine which pixels contain a target image based on the characteristic of the pixels. Another imaging apparatus includes a motorized stage, a camera having a lens directed toward the motorized stage, and a processor coupled to the camera.Type: GrantFiled: July 31, 2001Date of Patent: December 26, 2006Assignee: Trestle Acquisition Corp.Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: 6993169Abstract: A system for processing a thumbnail image from a microscope slide to determine tissue locations on the slide. The system comprises an image cropping component, a tissue finding component, and a scan control component. The image cropping component crops the thumbnail image and removes portions of the image that fall outside of determined slide boundaries. The cropped image from the image cropping component is inputted into the tissue finding component. The tissue finding component identifies tissue regions by applying a sequence of filters that incorporate knowledge of typical appearance and location of tissue and non-tissue slide regions. The tissue finding component outputs a tiling matrix whose values indicate which tiles should be imaged. The scan control component interprets the tiling matrix and transposes positions of the tiling matrix into actual stage coordinate for a microscopic imaging.Type: GrantFiled: January 11, 2001Date of Patent: January 31, 2006Assignee: Trestle CorporationInventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: 6816606Abstract: Today's technology allows montage images of large areas to be captured, stored and displayed at the resolution limit of the microscope optics. The invention reduces the overall time to capture a microscope slide by reducing the overhead associated with refocusing the optics at each tile location. Using a macroscopic image of the region to be scanned, representative focus positions are selected based on a predefined set of image characteristics. Prior to montage scanning, these focus positions are placed under the microscope optics and a best-focus position determined. A surface is fit to the resulting three-dimensional data. The parameters that define this surface are feed into the scanning control component to allow high-quality focused images to be acquired throughout the scanning process, eliminating the required stop, refocus, acquire image processing steps used in traditional montage imaging systems.Type: GrantFiled: February 21, 2001Date of Patent: November 9, 2004Assignee: InterScope Technologies, Inc.Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Patent number: 6798571Abstract: An illumination system for microscopic digital montage imaging based on a pulsed light illumination source triggered by the position of a specimen with respect to the optical axis of the microscope. The strobe illumination is used to facilitate high-speed tiled (montage) image capture of otherwise static specimens with higher throughput and significantly reduced mechanical precision requirements and cost. The invention allows for perfectly aligned montage tiles at high throughputs using standard microscope optics, having camera frame rate be the limiting factor in microscopic tiled image capture.Type: GrantFiled: January 11, 2001Date of Patent: September 28, 2004Assignee: InterScope Technologies, Inc.Inventors: Arthur W. Wetzel, John R. Gilbertson, II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, Jr.
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Publication number: 20020114497Abstract: Today's technology allows montage images of large areas to be captured, stored and displayed at the resolution limit of the microscope optics. The invention reduces the overall time to capture a microscope slide by reducing the overhead associated with refocusing the optics at each tile location. Using a macroscopic image of the region to be scanned, representative focus positions are selected based on a predefined set of image characteristics. Prior to montage scanning, these focus positions are placed under the microscope optics and a best-focus position determined. A surface is fit to the resulting three-dimensional data. The parameters that define this surface are feed into the scanning control component to allow high-quality focused images to be acquired throughout the scanning process, eliminating the required stop, refocus, acquire image processing steps used in traditional montage imaging systems.Type: ApplicationFiled: February 21, 2001Publication date: August 22, 2002Inventors: Arthur W. Wetzel, John R. Gilbertson, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri
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Publication number: 20020089740Abstract: An illumination system for microscopic digital montage imaging based on a pulsed light illumination source triggered by the position of a specimen with respect to the optical axis of the microscope. The strobe illumination is used to facilitate high-speed tiled (montage) image capture of otherwise static specimens with higher throughput and significantly reduced mechanical precision requirements and cost. The invention allows for perfectly aligned montage tiles at high throughputs using standard microscope optics, having camera frame rate be the limiting factor in microscopic tiled image capture.Type: ApplicationFiled: January 11, 2001Publication date: July 11, 2002Inventors: Arthur W. Wetzel, John R. Gilbertson, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri
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Publication number: 20020090127Abstract: An imaging apparatus is disclosed. The imaging apparatus includes a motorized stage, a camera focussed relative to the stage, and a processor coupled to the camera. The processor contains instructions which, when executed by the processor, cause the processor to capture an image incident on the camera, convert the image into a plurality of pixels having a characteristic such as intensity, establish the characteristic for each pixel; and determine which pixels contain a target image based on the characteristic of the pixels. Another imaging apparatus includes a motorized stage, a camera having a lens directed toward the motorized stage, and a processor coupled to the camera.Type: ApplicationFiled: July 31, 2001Publication date: July 11, 2002Applicant: InterScope Technologies, Inc.Inventors: Arthur W. Wetzel, John R. Gilbertson II, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri, JR.
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Publication number: 20020090120Abstract: A system for processing a thumbnail image from a microscope slide to determine tissue locations on the slide. The system comprises an image cropping component, a tissue finding component, and a scan control component. The image cropping component crops the thumbnail image and removes portions of the image that fall outside of determined slide boundaries. The cropped image from the image cropping component is inputted into the tissue finding component. The tissue finding component identifies tissue regions by applying a sequence of filters that incorporate knowledge of typical appearance and location of tissue and non-tissue slide regions. The tissue finding component outputs a tiling matrix whose values indicate which tiles should be imaged. The scan control component interprets the tiling matrix and transposes positions of the tiling matrix into actual stage coordinate for a microscopic imaging.Type: ApplicationFiled: January 11, 2001Publication date: July 11, 2002Inventors: Arthur W. Wetzel, John R. Gilbertson, Jeffrey A. Beckstead, Patricia A. Feineigle, Christopher R. Hauser, Frank A. Palmieri
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Patent number: 4372978Abstract: A method of inhibiting growth of bacteria comprising exposing the bacteria to an effective concentration of a polyunsaturated long-chain alcohol selected from the group consisting of linolenyl alcohol and linoleyl alcohol. The bacteria may be selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.A bactericidal product comprising an orally administerable product. The orally administerable product contains an effective concentration of antibacterial compound selected from the group consisting of linolenyl alcohol and linoleyl alcohol to produce an orally administerable product which will resist growth of bacteria selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.Type: GrantFiled: August 7, 1981Date of Patent: February 8, 1983Assignee: University of PittsburghInventors: John R. Gilbertson, Richard J. Crout
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Patent number: 4340628Abstract: A method of inhibiting growth of bacteria comprising exposing the bacteria to an effective concentration of a polyunsaturated long-chain alcohol selected from the group consisting of linolenyl alcohol and linoleyl alcohol. The bacteria may be selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.A bactericidal product comprising an orally administerable product. The orally administerable product contains an effective concentration of antibacterial compound selected from the group consisting of linolenyl alcohol and linoleyl alcohol to produce an orally administerable product which will resist growth of bacteria selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.Type: GrantFiled: November 26, 1979Date of Patent: July 20, 1982Inventors: John R. Gilbertson, Richard J. Crout
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Patent number: 4209533Abstract: A method of inhibiting growth of bacteria comprising exposing the bacteria to an effective concentration of a polyunsaturated long-chain alcohol selected from the group consisting of linolenyl alcohol and linoleyl alcohol. The bacteria may be selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.A bactericidal product comprising an orally administerable product. The orally administerable product contains an effective concentration of antibacterial compound selected from the group consisting of linolenyl alcohol and linoleyl alcohol to produce an orally administerable product which will resist growth of bacteria selected from the group consisting of Clostridium butyricum, Clostridium perfringens, Streptococcus mutans, Streptococcus mutans BHT and Streptococcus sanguis.Type: GrantFiled: January 25, 1979Date of Patent: June 24, 1980Assignee: University of PittsburghInventors: John R. Gilbertson, Richard J. Crout