Patents by Inventor John Rinn

John Rinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Retaining Splicing RNAs in the Nucleus Based on Chemically Modified Antisense Oligonucleotides
    Publication number: 20230257741
    Abstract: The inventive technology relates to systems and methods for the use of chemically modified antisense oligonucleotides (ASOs) to sterically prevent intron excision thus causing nuclear retention of the RNA and inhibiting nuclear export. In preferred therapeutic embodiments, ASOs may be engineered to quarantine clinically relevant RNAs in the nucleus of the cell.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 17, 2023
    Inventors: Gabrijela Dumbovic, John Rinn, Marvin Caruthers, Katarzyna Jastrzebska, Heera K. Langner
  • LINCRNA-DEFICIENT NON-HUMAN ANIMALS
    Publication number: 20230189771
    Abstract: Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 22, 2023
    Inventors: Ka-Man Venus Lai, Guochun Gong, John Rinn, David Frendewey, David M. Valenzuela
  • Method for screening gene expression in lincRNA-deficient mice or rats
    Patent number: 11547100
    Abstract: Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: January 10, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Ka-Man Venus Lai, Guochun Gong, John Rinn, David Frendewey, David M. Valenzuela
  • High-throughput methodology for identifying RNA-protein interactions transcriptome-wide
    Patent number: 9797887
    Abstract: Methods of identifying RNA-protein interaction sites are provided. Systems for identifying RNA-protein interaction sites are provided. Systems for identifying secondary structures are provided. Methods of identifying secondary structures are provided. Methods of identifying RNA-binding proteins are provided.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: October 24, 2017
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, PRESIDENT AND FELLOWS OF HARVARD COLLEGES
    Inventors: Brian D. Gregory, John Rinn, Fan Li, Cole Trapnell, Loyal A. Goff
  • LINCRNA-DEFICIENT NON-HUMAN ANIMALS
    Publication number: 20170071173
    Abstract: Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 16, 2017
    Inventors: Ka-Man Venus Lai, Guochun Gong, John Rinn, David Frendewey, David M. Valenzuela
  • IncRNA-knockout mice
    Patent number: 9554564
    Abstract: Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: January 31, 2017
    Assignees: Regeneron Pharmaceuticals, Inc., President and Fellows of Harvard College
    Inventors: Ka-Man Venus Lai, Guochun Gong, John Rinn, David Frendewey, David M. Valenzuela
  • HIGH-THROUGHPUT METHODOLOGY FOR IDENTIFYING RNA-PROTEIN INTERACTIONS TRANSCRIPTOME-WIDE
    Publication number: 20150355173
    Abstract: Methods of identifying RNA-protein interaction sites are provided. Systems for identifying RNA-protein interaction sites are provided. Systems for identifying secondary structures are provided. Methods of identifying secondary structures are provided. Methods of identifying RNA-binding proteins are provided.
    Type: Application
    Filed: June 9, 2015
    Publication date: December 10, 2015
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Brian D. Gregory, John Rinn, Fan Li, Cole Trapnell, Loyal A. Goff
  • High-throughput methodology for identifying RNA-protein interactions transcriptome-wide
    Patent number: 9097708
    Abstract: Methods of identifying RNA-protein interaction sites are provided. Systems for identifying RNA-protein interaction sites are provided. Systems for identifying secondary structures are provided. Methods of identifying secondary structures are provided. Methods of identifying RNA-binding proteins are provided.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: August 4, 2015
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Brian D. Gregory, John Rinn, Fan Li, Cole Trapnell, Loyal A. Goff
  • lincRNA-DEFICIENT NON-HUMAN ANIMALS
    Publication number: 20150047062
    Abstract: Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Ka-Man Venus Lai, Guochun Gong, John Rinn, David Frendewey, David M. Valenzuela
  • HIGH-THROUGHPUT METHODOLOGY FOR IDENTIFYING RNA-PROTEIN INTERACTIONS TRANSCRIPTOME-WIDE
    Publication number: 20130338009
    Abstract: Methods of identifying RNA-protein interaction sites are provided. Systems for identifying RNA-protein interaction sites are provided. Systems for identifying secondary structures are provided. Methods of identifying secondary structures are provided. Methods of identifying RNA-binding proteins are provided.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 19, 2013
    Inventors: Brian D. Gregory, John Rinn, Fan Li, Cole Trapnell, Loyal A. Goff
  • METHODS OF PREDICTING PAIRABILITY AND SECONDARY STRUCTURES OF RNA MOLECULES
    Publication number: 20100279302
    Abstract: Provided are methods of predicting a pairability of nucleotides of a plurality of RNA polynucleotides by (a) simultaneously determining a paired state or an unpaired state of nucleotides of the plurality of RNA polynucleotides; and (b) corresponding the paired state or the unpaired state of the nucleotides to a database of nucleic acid sequences, the database comprises nucleic acid sequences representing the plurality of RNA polynucleotides, thereby determining the pairability of nucleotides of the plurality of RNA polynucleotides. Also provided are methods of determining a secondary structure of a plurality of RNA molecules; methods of determining if a molecule is capable of modulating a secondary structure of at least one RNA polynucleotide of a plurality of RNA polynucleotides; and methods of screening for a marker associated with a pathology.
    Type: Application
    Filed: May 5, 2010
    Publication date: November 4, 2010
    Applicants: Yeda Research And Development Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eran Segal, Michael Kertesz, Howard Y. Chang, John Rinn, Adam Adler, Yue Wan