Abstract: This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.

Abstract: The present disclosure provides human interleukin 4 receptor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of inflammatory diseases, such as type 2 inflammatory diseases.

Abstract: Provided are, among other things, pistons and piston noses. One representative embodiment involves a brake piston that includes a piston body and a top surface, in which the top surface is wider than the piston body and has a small portion that is slightly raised, relative to the rest of the top surface, so that when in use only the small raised portion makes contact with a backing plate of a brake pad.

Abstract: Provided are, among other things, pistons and piston noses. One representative embodiment involves a brake piston that includes a piston body and a top surface, in which the top surface is wider than the piston body and has a small portion that is slightly raised, relative to the rest of the top surface, so that when in use only the small raised portion makes contact with a backing plate of a brake pad.

Abstract: Systems and methods for a filtering wave energy using a rectangular-to-circular waveguide transition are discussed herein. An exemplary system comprises a rectangular-to-circular waveguide transition and a filter card. The rectangular-to-circular waveguide transition may include a front section and a back section opposite the front section, the rectangular-to-circular waveguide transition defining a circular hole extending from the front section of the rectangular-to-circular waveguide transition through the back section, the rectangular-to-circular waveguide transition further having a first arcuate region on the face of the transition, the first arcuate region defining a first cavity extending from the circular hole through the first arcuate region, the rectangular-to-circular waveguide transition also having a second arcuate region defining a second cavity opposite the first cavity, the second cavity extending from the circular hole through the second arcuate region.

Abstract: Provided are, among other things, pistons and piston noses. One representative embodiment involves a brake piston that includes a piston body and a top surface, in which the top surface is wider than the piston body and has a small portion that is slightly raised, relative to the rest of the top surface, so that when in use only the small raised portion makes contact with a backing plate of a brake pad.

Abstract: Provided are, among other things, systems, apparatuses, components and methods related to drive pin assemblies. One such assembly includes: a first pin component and a second pin component, each having an engagement end that opens to an interior space and has an angled surface that extends for at least a portion of the width and a portion of the length of such first pin component; and a tightening mechanism at least partially disposed within the interior spaces of the first pin component and the second pin component, for drawing the first pin component and the second pin component closer together, where the angled surface of the first pin component matches the angled surface of the second pin component such that the first pin component and the second pin component slide both vertically and laterally along each other when drawn together.

Abstract: Provided are, among other things, systems, apparatuses, components and methods related to drive pin assemblies. One such assembly includes: a first pin component and a second pin component, each having an engagement end that opens to an interior space and has an angled surface that extends for at least a portion of the width and a portion of the length of such first pin component; and a tightening mechanism at least partially disposed within the interior spaces of the first pin component and the second pin component, for drawing the first pin component and the second pin component closer together, where the angled surface of the first pin component matches the angled surface of the second pin component such that the first pin component and the second pin component slide both vertically and laterally along each other when drawn together.

Abstract: Provided is, among other things, a disc brake caliper that includes: a unitary main housing, a leading reinforcement element and a trailing reinforcement element. The unitary main housing is made of a first material and includes: (a) an inner portion, (b) an outer portion, (c) a leading crossover section that extends between the inner portion and the outer portion, forward of both the inner opening and the outer opening, and over the brake rotor when in use, and (d) a trailing crossover section that extends between the inner portion and the outer portion, behind both the inner opening and the outer opening, and over the brake rotor when in use.

Abstract: Provided are, among other things, pistons and piston noses. One representative embodiment involves a brake piston that includes a piston body and a top surface, in which the top surface is wider than the piston body and has a small portion that is slightly raised, relative to the rest of the top surface, so that when in use only the small raised portion makes contact with a backing plate of a brake pad.

Abstract: Systems and methods for a filtering wave energy using a rectangular-to-circular waveguide transition are discussed herein. An exemplary system comprises a rectangular-to-circular waveguide transition and a filter card. The rectangular-to-circular waveguide transition may include a front section and a back section opposite the front section, the rectangular-to-circular waveguide transition defining a circular hole extending from the front section of the rectangular-to-circular waveguide transition through the back section, the rectangular-to-circular waveguide transition further having a first arcuate region on the face of the transition, the first arcuate region defining a first cavity extending from the circular hole through the first arcuate region, the rectangular-to-circular waveguide transition also having a second arcuate region defining a second cavity opposite the first cavity, the second cavity extending from the circular hole through the second arcuate region.

Abstract: The invention includes a mounting hat for a brake rotor having a lower section connected to an upper section. Also included is a plurality of aerodynamically shaped standoff vanes each having a leading edge, a trailing edge, a top and a bottom connected to the upper section. Further, a plurality of vents are formed between adjacent aerodynamically shaped standoff vanes. The vents are circumferentially distributed on the upper section. Air flow is induced to flow through the plurality of vents. Alternatively included is a mounting hat for a brake rotor having a lower section connected to an upper section. Also included is a plurality of first aerodynamically shaped standoff vanes each having a leading edge, a trailing edge, a top and a bottom connected to the upper section. Further, a plurality of second aerodynamically shaped standoff vanes each having a leading edge, a trailing edge and a top connected to the upper section is included.

Abstract: Waveguide flanges for joining waveguide sections or components are designed to achieve mechanical strength and exhibit desired electrical properties such as relatively low insertion loss and high return loss. The present invention contemplates waveguide interfaces with a new choke flange designed to engage with a shield flange and provide a joint with improved electrical properties. The new choke designs produce a virtual continuity through the waveguide joints and minimize electrical energy leakage. The electrical and mechanical properties of the joint in the waveguide interfaces are robust and able to tolerate lower levels of parts precision, imperfect mating of the flanges without metal-to-metal contact and gaps up to 0.06? or more between the mating flange surfaces.

Abstract: The invention includes a mounting hat for a brake rotor having a lower section connected to an upper section. Also included is a plurality of aerodynamically shaped standoff vanes each having a leading edge, a trailing edge, a top and a bottom connected to the upper section. Further, a plurality of vents are formed between adjacent aerodynamically shaped standoff vanes. The vents are circumferentially distributed on the upper section. Air flow is induced to flow through the plurality of vents. Alternatively included is a mounting hat for a brake rotor having a lower section connected to an upper section. Also included is a plurality of first aerodynamically shaped standoff vanes each having a leading edge, a trailing edge, a top and a bottom connected to the upper section. Further, a plurality of second aerodynamically shaped standoff vanes each having a leading edge, a trailing edge and a top connected to the upper section is included.

Abstract: Waveguide flanges for joining waveguide sections or components are designed to achieve mechanical strength and exhibit desired electrical properties such as relatively low insertion loss and high return loss. The present invention contemplates waveguide interfaces with a new choke flange designed to engage with a shield flange and provide a joint with improved electrical properties. The new choke designs produce a virtual continuity through the waveguide joints and minimize electrical energy leakage. The electrical and mechanical properties of the joint in the waveguide interfaces are robust and able to tolerate lower levels of parts precision, imperfect mating of the flanges without metal-to-metal contact and gaps up to 0.06? or more between the mating flange surfaces.

Abstract: A ventilated brake rotor having vents disposed between two discs. The vents are defined by an adjacent pair of vanes distributed around the first disc and disposed below the second disc. Each vane is defined by a camber. The camber, in turn, is parallel to a curve that is defined by two camber lines. The curve is tangent to the leading end of a first camber line and tangent to a trailing end of the second camber line. The first and the second camber lines intersect where the first camber line is defined from a point on the interior radius of one of the two discs that intersects a datum. Moreover, the first camber line extends at a throat angle from the datum.

Abstract: A ventilated brake rotor having vents disposed between two discs. The vents are defined by an adjacent pair of vanes distributed around the first disc and disposed below the second disc. Each vane is defined by a camber. The camber, in turn, is parallel to a curve that is defined by two camber lines. The curve is tangent to the leading end of a first camber line and tangent to a trailing end of the second camber line. The first and the second camber lines intersect where the first camber line is defined from a point on the interior radius of one of the two discs that intersects a datum. Moreover, the first camber line extends at a throat angle from the datum.

Abstract: A stiffening bracket for a brake caliper that includes an aperture. The aperture has a diagonal length. The bracket includes a support having a first end and a second end. The bracket also includes a first extension attached to the first end and a second extension attached to the second end of the support. A length measured from the first extension to the second extension of the bracket is less than or equal to the diagonal length of the aperture.

Abstract: A method and apparatus for improving the performance of Building Environmental Control networks by efficiently storing network routing information and by checking that the data exchanged between two computer applications operating on the network is consistent. The present invention efficiently stores network routing information by having the Building Environmental control network routers only store routing information when that router acts as a bridge for communicating that message further downstream. The present invention also checks that the exchange of data between two building environmental control applications is done by forming a special identifier from the existing data and using that identifier to validate data exchanges. The special identifier is formed by segmenting one field found within the data and having a portion of that segmented field be indicative of the identifying name of the data.

Abstract: A method for determining the physical locations of devices located on a series connected network. A mapper routine located on the network severs a device from the network and then requests each device to respond with its respective node address to the mapper. Upon receiving the responses, the severed device is reattached to the network. This severing, requesting, and reattaching is performed for each remaining device on the network. The mapper routine determines the physical location of each device by correlating what responses from the devices were generated for which severed devices.