Abstract: The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions.

Abstract: The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions.

Abstract: The present application relates to novel compounds comprising a moiety that leads to the metabolic production of ketones bonded to a ketone-potentiated anti-epileptic drug, compositions comprising these compounds, and their use, for example for the treatment of epilepsy, and other CNS diseases, disorders or conditions.

Abstract: The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.

Abstract: The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.

Abstract: The present invention relates to novel 3,5-substituted indole compounds of Formula (I) having nitric oxide synthase (NOS) inhibitory activity together with inhibitory activity at the norepinephrine transporter (NET), to pharmaceutical and diagnostic compositions containing them, and to their medical use.

Abstract: Compounds of formula I ##STR1## in which R.sup.A, B (which is CR.sup.4) and R.sup.3 and have the meaning indicated in the application, as well as their production and their use in pharmaceutical agents, are described.

Abstract: N-hetaryl imidazole derivatives of general Formula I ##STR1##are disclosed in whichHet represents an optionally substituted monocyclic or bicyclic heteroaromate,R.sup.3 represents hydrogen, a straight or branched C.sub.1-6 -alkyl group, or a C.sub.1-6 -alkoxy-alkyl group, andR.sup.4 represents --COOR.sup.5 --CONR.sup.6 R.sup.7 --CN, ##STR2##with R.sup.5 meaning hydrogen, a straight or branched C.sub.1-6 -alkyl group, R.sup.6 and R.sup.7 are the same of different and represent hydrogen or a straight, branched, or cyclic alkyl group with up to 7 carbon atoms or, together with the nitrogen atom, form a saturated five or six ring optionally containing another heteroatom and R.sup.8 means hydrogen or a straight, branched or cyclic alkyl group with up to 7 carbon atoms.

Abstract: A radial upblast exhaust fan apparatus including a main housing having a fan housing in the lower portion thereof and an upper housing thereabove. A passive zone is defined between two lateral sections of the upper housing such as to divide the air flow path into two sections. The passive zone section defines a first inner wall and a second inner wall which cooperate with a first outer wall and a second outer wall defined by the upper housing to provide a first exhaust flow path and a second exhaust flow path. These walls are shaped as sectors of conical sections preferably and include end walls to isolate the first exhaust flow path from fluid flow communication with respect to the second exhaust flow path. A fan means is positionable within the fan housing to urge exhaust gases to flow upwardly through the exhaust paths. The walls of the exhaust flow paths are generally arcuate to facilitate exhaust flow.

Abstract: A U-loop air handling apparatus adapted to receive air from a surrounding environment for conditioning and channeling thereof to return ducts. The conditioning includes cooling and filtration thereof such as to be specifically usable in high technology areas requiring extremely clean working conditions. The apparatus includes a fan operatively positioned between an intake section and an output section. The intake section includes a reducing section for receiving air and passing this air through a pre-filter and a cooling coil. Condensation is removed at the cooling coil and a cross sectional area of the channel of air travel is narrowed to a smaller diameter by the reducing section. A fan box receives the conditioned air from the reducing section where it is carried through an inlet box and bell member into the fan. The fan powers the air outwardly into an acoustical box which channels the air parallel and in an opposite direction with respect to the direction of movement of the air within the intake section.

Abstract: A silencer having a tubular configuration which can be interposed in a duct and form a part of the duct walls. The silencer has an inner perforate wall and an outer imperforate wall. The annular space between the two walls is filled with acoustical sound absorbing materials. The outer imperforate wall is adapted for quick opening to permit easy replacement of the sound absorbing materials.

Abstract: A gaseous stream is freed of its particulate material in apparatus which includes a casing having an inlet opening, an outlet opening, and an impingement screen disposed across the inlet opening and comprising single or multiple, preferably staggered rows of impingement elements of V-shaped transverse profile positioned with the apex thereof facing the inlet opening. As the gaseous stream flows through the impingement screen, vortices are formed at the trailing edge of each element whereby droplets in the gaseous stream are entrained into the vortices, spin into a low pressure region which exists inside the open rear of the impingement element, and drain by gravity to collecting means. A series of radially extending vanes positioned downstream of the impingement screen impart swirl to the gaseous stream. A series of coaxial frustoconical rings are provided downstream of the vanes. Support means maintain the coaxial frustoconical rings in overlapping arrangement.