Abstract: Provided herein are inhibitors of MET receptor tyrosine kinase, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said MET kinase inhibitory compounds for the treatment of disease.

Abstract: A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device.

Abstract: A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device.

Abstract: A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device.

Abstract: A first computing device receives a first request from a client computing device, wherein the first request includes a markup language request. The first computing device transmits the first request to a second computing device, wherein the second computing device services the first request. The first computing device receives the serviced first request, wherein the serviced first request includes a manifest tag. The first computing device caches the serviced first request. The first computing device transmits the serviced first request to the client computing device.

Abstract: The present invention is a method and system that provides visual, production level, high-performance, integrated and automatic data integrity verification in a Web-based, e-business or other similar application, using a middleware application server. Asynchronous messaging is utilized to achieve real-time data verification. When data is read and updated by the application running in the application server, a message containing certain aspects of the data is published to a data auditor “queue” in the message server. Publishing the data is an asynchronous and high-performance operation and thus does not significantly slow down the operation being performed by the application server. The message is delivered to the message server and control immediately returns to the application to continue processing. Concurrently, the auditor checks the values resulting from the transaction and determines if the transactions have been recorded accurately.

Abstract: In a Web application testing method which has been configured in accordance with the present invention, a network message from one of several network clients can be intercepted. Session data in the network message can be identified and state information retrieved for the session in the Web application. An operation and corresponding associated parameters can be selected from a Web scenario template based upon the retrieved state information. Finally, operations can be invoked in the Web application, the operations corresponding to the operation and associated operational parameters selected from the Web scenario template.

Abstract: An object state caching method can include augmenting a compiled object having at least one referenced method with conditional caching logic. The conditional caching logic can be executed in an execution environment to determine whether to execute the referenced method. If the conditional caching logic determines not to execute the referenced method, the execution of the referenced method can be bypassed. Additionally, the stored object state can be retrieved from a communicatively coupled object cache. Finally, the retrieved object state can be forwarded to a requesting process. If, however, the conditional caching logic determines to execute the referenced method, the referenced method can be executed producing the resultant object state, and, the resultant object state can be cached in the coupled object cache.

Abstract: An object state caching method can include augmenting a compiled object having at least one referenced method with conditional caching logic. The conditional caching logic can be executed in an execution environment to determine whether to execute the referenced method. If the conditional caching logic determines not to execute the referenced method, the execution of the referenced method can be bypassed. Additionally, the stored object state can be retrieved from a communicatively coupled object cache. Finally, the retrieved object state can be forwarded to a requesting process. If, however, the conditional caching logic determines to execute the referenced method, the referenced method can be executed producing the resultant object state, and, the resultant object state can be cached in the coupled object cache.

Abstract: A method for enhanced fragment caching. The method can include identifying in at least one of first and second retrieved page fragments a variable object utilized by the fragment upon execution to produce dynamic content. Separate cache entries can be written for the first and second retrieved page fragments where the first and second retrieved page fragments differ in ways other than an evaluation of the variable object. Otherwise, a single cache entry can be written for both the first and second retrieved page fragments where the first and second retrieved page fragments differ only in the evaluation of the variable object.

Abstract: A Web application testing method. A network message from one of several network clients can be intercepted. Session data in the network message can be identified and state information retrieved for the session in the Web application. An operation and corresponding associated parameters can be selected from a Web scenario template based upon the retrieved state information. Finally, operations can be invoked in the Web application, the operations corresponding to the operation and associated operational parameters selected from the Web scenario template.

Abstract: A method for enhanced fragment caching. The method can include identifying in at least one of first and second retrieved page fragments a variable object utilized by the fragment upon execution to produce dynamic content. Separate cache entries can be written for the first and second retrieved page fragments where the first and second retrieved page fragments differ in ways other than an evaluation of the variable object. Otherwise, a single cache entry can be written for both the first and second retrieved page fragments where the first and second retrieved page fragments differ only in the evaluation of the variable object.

Abstract: A non-uniform memory accessing (NUMA) based multiprocessor system that promotes local memory accessing and data migration to local processor nodes. The system includes mechanisms to re-map virtual and physical addresses to promote local memory accessing and implements a least recently used memory allocation mechanism to age non-local memory accesses out of memory to be re-read into local memory, which promotes data migration to local memory on processor nodes.