Abstract: One or more techniques for optimizing cancer classification based on covariate characteristics is disclosed. In a first approach, an analytics system may determine separate cutoff thresholds for positively detecting disease signal for different labels for a covariate characteristic. The system may subdivide training samples based on their labels for the covariate characteristic, to separately determine the cutoff thresholds. In other approaches, the system may train disparate classifiers for each population. The system separates the training samples based on their labels for the covariate characteristic, and separately trains classifiers to generate a signal vector representing an amount of disease signal detected in a sample. The classifiers may be trained on different feature sets as determined based on mutual information gain, genomic region coverage, and healthy activation fraction.

Abstract: The viscometer (100) includes a difference amplifier (110) driven by a signal generator (111) which supplies a control signal to shaker (120), which is sufficiently powerful to impose such strains as may be demanded by a controlling reference voltage with a desired form. The shaker (120) drives a shaft (125), and an upper plate (130) is attached to a distal end of the shaft (125). A lower plate (140) is positioned adjacent, and substantially parallel to, upper plate (130), thereby creating a space that may be filled by fluid sample (150). The motion of the upper plate h(t) is measured by a sensor (180). Plate (140) is mounted on force measuring means (160) which keeps lower plate (140) substantially motionless relative to frame (165). Force measuring means (160) provides an output, or force, signal f(t) that is indicative of the force which fluid sample (150) exerts on plate (130 and 140) in response to the movement of upper plate (130).

Abstract: A penetration measuring apparatus comprising a stage for mounting a sample of the material to be tested thereon, a probe having one end thereof proximal to the stage and having a longitudinal axis extending orthogonally of the stage, an ultra-microhardness indenter located in the one end of the probe, and a carriage assembly to which the probe is connected via an intermediate member, a first elastic connector of known stiffness connecting the probe to the intermediate member and a second elastic connector of known stiffness connecting the intermediate member to the carriage. The first and second connectors allow axial movement of the probe but prevent movement of the probe in any other direction. A driving device is provided for driving the carriage towards and away from the stage and a first measuring device measures the movement of the probe relative to a stationary datum. A second measuring device is provided which measures the deformation of the elastic connector connecting the probe to the carriage.