Abstract: The present invention relates to the engineering an animal model, preferably mammalian models, more preferably a rat model representing Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in a severe, early-onset axonal neuropathy. A model having the p.Arg364Trp Mfn2 mutation is based on a mutation made using zinc finger endonuclease technology in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized behaviorally and shown to develop multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type rats sacrificed at 7, 40, and 48 weeks and analyzed by light microscopy showed a reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks.

Abstract: A system for cooling a refrigerant includes (a) an evaporator comprising one or more lengths of tubing each having an upstream first cross-sectional area and a second downstream cross-sectional area, the second cross-sectional area being greater than the first cross-sectional area, the expansion in cross-sectional area between the first circular cross-sectional area and the second circular cross-sectional area being smooth and continuous; and (b) a compressor and a condenser for converting the refrigerant from a gas to a liquid for introduction into the evaporator.

Abstract: A refrigeration system has: (a) a fluid tight circulation loop including a compressor, a condenser and an evaporator, the evaporator having at least three evaporator zones, each evaporator zone having an inlet port, the circulation loop being further configured to measure the condition of the refrigerant with a refrigerant condition sensor disposed within the evaporator upstream of the evaporator outlet port; and control the flow of refrigerant to the evaporator based upon the measured condition of the refrigerant within the evaporator, and (b) a controller for controlling the flow rate of refrigerant to the evaporator based upon the measured condition of the refrigerant within the evaporator upstream of the evaporator outlet port.

Abstract: A refrigeration system has: (a) a fluid tight circulation loop including a compressor, a condenser and an evaporator, the evaporator having at least three evaporator zones, each evaporator zone having an inlet port, the circulation loop being further configured to measure the condition of the refrigerant with a refrigerant condition sensor disposed within the evaporator upstream of the evaporator outlet port; and control the flow of refrigerant to the evaporator based upon the measured condition of the refrigerant within the evaporator, and (b) a controller for controlling the flow rate of refrigerant to the evaporator based upon the measured condition of the refrigerant within the evaporator upstream of the evaporator outlet port.

Abstract: A system for cooling a refrigerant includes (a) an evaporator comprising one or more lengths of tubing each having an upstream first cross-sectional area and a second downstream cross-sectional area, the second cross-sectional area being greater than the first cross-sectional area, the expansion in cross-sectional area between the first circular cross-sectional area and the second circular cross-sectional area being smooth and continuous; and (b) a compressor and a condenser for converting the refrigerant from a gas to a liquid for introduction into the evaporator.

Abstract: A high efficiency, self-modulating refrigeration system has three principal parts, including (1) a compression refrigeration circuit, (2) an absorption refrigeration circuit coupled in cascade with the compression circuit, and (3) an engine or prime mover/electric generator combination, with the electric generator supplying power to the compressors, pumps, fans and other auxiliary equipment, of the refrigeration circuits, and the waste heat from the prime mover or engine being supplied to the still, or reboilers associated with the absorption refrigeration circuit. Ammonia is used in the absorption circuit, and ammonia or Freon is preferably used in the compression circuit. For retrofitting of compression systems, the existing compression and other equipment may be retained, and employed when servicing or repairing the absorption circuit, or engine generator. Multiple staging may be employed, and the various circuits may be intercoupled from a heat exchange standpoint at several points in the circuits.

Abstract: A high efficiency, self-modulating refrigeration system has three principal parts, including (1) a compression refrigeration circuit, (2) an absorption refrigeration circuit coupled in cascade with the compression circuit, and (3) an engine or prime mover/electric generator combination, with the electric generator supplying power to the compressors, pumps, fans and other auxiliary equipment, of the refrigeration circuits, and the waste heat from the prime mover or engine being supplied to the still, or reboilers associated with the absorption refrigeration circuit. Ammonia is used in the absorption circuit, and ammonia or Freon is preferably used in the compression circuit. For retrofitting of compression systems, the existing compression and other equipment may be retained, and employed when servicing or repairing the absorption circuit, or engine generator. Multiple staging may be employed, and the various circuits may be intercoupled from a heat exchange standpoint at several points in the circuits.

Abstract: The invention is a nail polish remover kit for removing nail polish from fingers and toenails. The kit has a pear-shaped jar containing a nail polish remover saturated filler. The filler is constricted at the top by the constricted upper portion of the jar to prevent both rotation of the filler and visual sighting of the sludge at the bottom of the jar, produced by nail polish removal process. The filler possesses an opening for inserting a finger having a nail from which polish is to be removed. The opening may be formed from filler surfaces which are smooth or uneven, and, if uneven, preferably corrugated. The opening is dimensioned so that excess nail polish remover is wiped from the finger as it is removed from the filler. The kit also contains a dauber with an absorbent end that the filler opening is designed to receive. This dauber may be removed from the filler to remove polish from toenails, fingernails, and the like.

Abstract: A high efficiency, self-modulating refrigeration system has three principal parts, including (1) a compression refrigeration circuit, (2) an absorption refrigeration circuit coupled in cascade with the compression circuit, and (3) an engine or prime mover/electric generator combination, with the electric generator supplying power to the compressors, pumps, fans and other auxiliary equipment, of the refrigeration circuits, and the waste heat from the prime mover or engine being supplied to the still, or reboilers associated with the absorption refrigeration circuit. Ammonia is used in the absorption circuit, and ammonia or Freon is preferably used in the compression circuit. For retrofitting of compression systems, the existing compression and other equipment may be retained, and employed when servicing or repairing the absorption circuit, or engine generator. Multiple staging may be employed, and the various circuits may be intercoupled from a heat exchange standpoint at several points in the circuits.