Abstract: The present invention relates to an optimized chimeric antigen receptor (CAR), and genetically modified cells expressing the same, that can target a diverse range of cancer types. More specifically, the CAR has an optimized linker length that facilitates the targeting and lyse of a wide range of cancer cell types by CAR expressing T cells.

Abstract: The present invention provides markers of regulatory T (Treg) cells, preferably, cell surface markers of Treg cells and uses of those markers or compounds that bind thereto to identify or isolate Treg cells or to diagnose/prognose/treat/prevent Treg-mediated conditions. The present invention also provides methods for identification and/or isolation of Treg cell subpopulations and such isolated subpopulations of Treg cells.

Abstract: The present invention provides markers of regulatory T (Treg) cells, preferably, cell surface markers of Treg cells and uses of those markers or compounds that bind thereto to identify or isolate Treg cells or to diagnose/prognose/treat/prevent Treg-mediated conditions. The present invention also provides methods for identification and/or isolation of Treg cell subpopulations and such isolated subpopulations of Treg cells.

Abstract: A biometric access control and time and attendance system comprises an integrated network including one or more remote access devices in electronic communication with a computer database. Each remote access device comprises a silicon chip based system and preferably includes a biometric input device, a liquid crystal display (LCD), computer processing capabilities, and an electrical output for controlling a door lock or the like. A plurality of remote access devices is configured for communication with a primary computer database wherein data corresponding to biometric samples for all authorized users is stored.