Abstract: The invention features a drug delivery device held in the mouth and continuously administering either a fluid comprising drug dissolved and/or dispersed in water or in a non-toxic liquid, or a drug in solid form.

Abstract: A graft device for a mammalian patient tubular conduit comprises a fiber matrix surrounding the tubular conduit and a spine comprising a first support portion and a second support portion. At least one of the first support portion or the second support portions can be constructed and arranged to rotate relative to the other to receive the tubular conduit. The first support portion can comprise a first set of projections and the second support portion can comprise a second set of projections that interdigitiate with the first set of projections. Tools for creating the spine and for applying the spine are also provided.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: A device and method for treating a variety of conditions, disorders or diseases with diaphragm/phrenic nerve stimulation is provided.

Abstract: An endovascular prosthesis of the present invention includes an expandable stent and a means for sealably attaching a tubular graft to the stent within the stent's lumen. The means of sealably attaching a graft includes membranes, foams, polymeric materials and combinations thereof. Additionally, the present invention includes methods of forming an endovascular prosthesis and methods of implanting an endovascular prosthesis within a vessel to provide sealable securement of a tubular graft within the stent's lumen.

Abstract: Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: Particles and related methods are disclosed.

Abstract: An electronic and transducer device can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a two-way communication assembly. The device contains a motion sensor to detect external forces imposed on the user such as an explosion, for example. The information is stored for medical treatment, among others. In another embodiment, the device provides an electronic and transducer device that can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a medical tag containing patient identifiable information. Such an oral appliance may be a custom-made device fabricated from a thermal forming process utilizing a replicate model of a dental structure obtained by conventional dental impression methods.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: An electronic and transducer device can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a two-way communication assembly. The device contains a motion sensor to detect external forces imposed on the user such as an explosion, for example. The information is stored for medical treatment, among others. In another embodiment, the device provides an electronic and transducer device that can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a medical tag containing patient identifiable information. Such an oral appliance may be a custom-made device fabricated from a thermal forming process utilizing a replicate model of a dental structure obtained by conventional dental impression methods.

Abstract: An intra-oral hearing appliance includes an actuator to provide bone conduction sound transmission; a transceiver coupled to the actuator to cause the actuator to generate sound; and a first chamber containing the actuator and the transceiver, said first chamber adapted to be coupled to one or more teeth.

Abstract: An intra-oral hearing appliance includes an actuator to provide bone conduction sound transmission; a transceiver coupled to the actuator to cause the actuator to generate sound; and a first chamber containing the actuator and the transceiver, said first chamber adapted to be coupled to one or more teeth.

Abstract: Nasal irrigation systems for irrigating and/or rinsing a subject's nasal cavity are disclosed herein. Irrigation fluid may be drawn through the nasal cavity while utilizing a staged treatment procedure which allows for an initial infusion or flushing of irrigation fluid, circulation of the fluid, and subsequent flushing of the effluent from the nasal cavity. The system allows for reversible flow of the fluid during irrigation as well as use of vibration to disrupt debris within the nasal cavity to facilitate the mixing and removal of the debris. Additionally, peristaltic flow of the irrigation fluid may be used to facilitate contact between the fluid and debris during fluid circulation. Moreover, the irrigation fluid may also incorporate air or a gas into the fluid flow to create discrete volumes or boluses of pressured fluid to further facilitate thorough irrigation of the nasal cavity.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: Methods and apparatus for transmitting vibrations via an electronic and/or actuator assembly through a custom-fitted dental appliance are disclosed herein. The customized fitting is done by the user. The assembly may be attached, adhered, or otherwise embedded intra-orally on a tooth or oral tissue. The electronic and actuator assembly may receive incoming sounds either directly or through a receiver to process and amplify the signals and transmit the processed sounds via a vibrating actuator element coupled to a tooth or other bone structure, such as the maxillary, mandibular, or palatine bone structure.

Abstract: Systems and methods are disclosed for capturing sound for communication by mounting one or more intra-oral microphones to capture sound; and mounting a mouth wearable communicator in the oral cavity to communicate sound with a remote unit.

Abstract: Systems and methods are disclosed for charging an intra-oral apparatus includes an intra-oral appliance having an appliance charger coil defining a first portion of an electromagnetic loop; and a charger base having a base charger coil defining a second portion of the electromagnetic loop, wherein the appliance charger coil and the base charger coil in combination transfer energy for inductive charging.

Abstract: An electronic and transducer device can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a two-way communication assembly. The device contains a motion sensor to detect external forces imposed on the user such as an explosion, for example. The information is stored for medical treatment, among others. In another embodiment, the device provides an electronic and transducer device that can be attached, adhered, or otherwise embedded into or upon a removable oral appliance or other oral device to form a medical tag containing patient identifiable information. Such an oral appliance may be a custom-made device fabricated from a thermal forming process utilizing a replicate model of a dental structure obtained by conventional dental impression methods.