Abstract: A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.

Abstract: An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir.

Abstract: Described herein are implantable coated medical devices, such as intravascular stents, for delivering therapeutic agents to the body tissue of a patient, and methods for making such medical devices. In particular, described herein are implantable coated medical devices comprising a substrate having a surface, and a coating disposed upon the surface that comprises a coating composition that includes a releasable metal oxide. The coating is free of polymer or a particular type of polymer that is not a part of any releasable metal oxide.

Abstract: The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.

Abstract: A medical device comprising radiopaque water-dispersible metallic nanoparticles, wherein the nanoparticles are released from the medical device upon implantation of the device. The medical device of the present invention is sufficiently radiopaque for x-ray visualization during implantation, but loses its radiopacity after implantation to allow for subsequent visualization using more sensitive imaging modalities such as CT or MRI. The nanoparticles are formed of a metallic material and have surface modifications that impart water-dispersibility to the nanoparticles. The nanoparticles may be any of the various types of radiopaque water-dispersible metallic nanoparticles that are known in the art. The nanoparticles may be adapted to facilitate clearance through renal filtration or biliary excretion. The nanoparticles may be adapted to reduce tissue accumulation and have reduced toxicity in the human body. The nanoparticles may be applied directly onto the medical device, e.g.

Abstract: An oriented strand board (OSB)-fiberboard composite structure is comprised of a baseboard having three wood strand layers, the wood strands being oriented in space with respect to a board forming machine such that a core layer is comprised of wood strands oriented generally in a random or cross-machine direction and each adjacent layer is comprised of coarse and fine wood strands oriented generally in the machine direction. In a preferred embodiment, the wood strands comprising each adjacent OSB layer are formed with the coarsest strands located nearest the core layer and the finest strands are located nearest the outer surfaces of each outer board layer. The OSB-fiberboard composite product is clad with a wood fiber overlay on one major surface of the baseboard. The composite board is manufactured without warping, by providing particular OSB layer thicknesses, such that the lower OSB layer is about 25% to about 35% thicker than the OSB layer bonded to the fiberboard.

Abstract: An oriented strand board product is provided. The board is comprised of a baseboard having three wood strand layers, the wood strands being oriented in space with respect to a board-forming machine such that a core layer is comprised of wood strands oriented generally in a random or cross-machine direction and each adjacent layer is comprised of coarse and fine wood strands oriented generally in the machine direction and wherein the wood strands comprising each adjacent layer are formed with the coarsest strands located nearest the core layer and the finest strands are located nearest the outer surfaces of each outer board layer. The OSB board product is clad with a dry felted wood fiber overlay on one planar surface of the baseboard.

Abstract: A plurality of intermittent incisions are made in the surface region of a fiberboard to sever fibers without removing them from said region. The resultant fiberboard may be molded under heat and pressure to a three dimensional hardboard with high fidelity to the mold and without causing stretch marks, tears or fractures. The fiberboard may be a dry consolidated mass of wet felted cellulosic fibers. The invention is particularly valuable in the molding of boards made from redwood fibers and other long fibers.The intermittent incisions may be made along one or more lines parallel to or perpendicular to the longitudinal edge of the fiberboard but a grid of incisions along intersecting lines is advantageous. To cut the incisions, the fiberboard is moved on a conveyor belt while an assemblage of toothed cutting disks is rotated in cutting engagement with the board. The cutting disks are mounted co-axially on a motor-driven shaft.

Abstract: An oriented strand board (OSB)-fiberboard composite structure is comprised of a baseboard having three wood strand layers, the wood strands being oriented in space with respect to a board forming machine such that a core layer is comprised of wood strands oriented generally in a random or cross-machine direction and each adjacent layer is comprised of coarse and fine wood strands oriented generally in the machine direction. In a preferred embodiment, the wood strands comprising each adjacent OSB layer are formed with the coarsest strands located nearest the core layer and the finest strands are located nearest the outer surfaces of each outer board layer. The OSB-fiberboard composite product is clad with a wood fiber overlay on one major surface of the baseboard. The composite board is manufactured without warping, by providing particular OSB layer thicknesses, such that the lower OSB layer is about 25% to about 35% thicker than the OSB layer bonded to the fiberboard.

Abstract: An oriented strand board product is provided. The board is comprised of a baseboard having three wood strand layers, the wood strands being oriented in space with respect to a board forming machine such that a core layer is comprised of wood strands oriented generally in a random or cross-machine direction and each adjacent layer is comprised of coarse and fine wood strands oriented generally in the machine direction and wherein the wood strands comprising each adjacent layer are formed with the coarsest strands located nearest the core layer and the finest strands are located nearest the outer surfaces of each outer board layer. The OSB board product is clad with a dry felted wood fiber overlay on one planar surface of the baseboard.

Abstract: A fiberboard, preferably made by consolidating a water-felted mat without added binder and being suitable for pressure-molding into a hardboard door facing having a high degree of fidelity to the contours of the die set, is incised on both the major face and the obverse face with incisions having a depth of from about 10% to about one third the thickness of the board. The incisions are aligned on lines that are preferably arranged at right angles across the face of the board. The lines are preferably spaced a maximum of about 0.5 inches apart, and the incisions on each line are discontinuous, preferably separated by a maximum of about 0.5 inches.

Abstract: A fiberboard is manufactured having relatively high density skins on a relatively low density core by including a skin forming chemical in at least the surface fibers of a consolidated mat, having a density of less than 35 pounds per cubic foot, and then hot-pressing the consolidated mat at a temperature of at least 525.degree. F. to form a board having high density surface skins. In accordance with another embodiment of the present invention, a skin forming chemical is used to form a skin on higher density mats having a density of 35 pounds/ft..sup.3 or greater. The skin formed on the higher density mats has strength and density properties which are not as significantly different from the core material as is the skin formed over the low density core material of the first embodiment, but the skin on the higher density mats also improves the board strength, stiffness paint holdout and design fidelity properties.

Abstract: A fiberboard is manufactured having relatively high density skins on a relatively low density core by including urea in at least the surface fibers of a consolidated mat, having a density of less than 35 pounds per cubic foot, and then hot-pressing the consolidated mat at a temperature of at least 525.degree. F. to form a board having high density surface skins. In accordance with another embodiment of the present invention, urea is used to form a skin on higher density mats having a density of 35 pounds/ft..sup.3 or greater. The skin formed on the higher density mats has strength and density properties which are not as significantly different from the core material as is the skin formed over the low density core material of the first embodiment, but the skin on the higher density mats also improves the board strength, stiffness, paint holdout and design fidelity properties.

Abstract: Multi-sided decorative moldings and furniture parts are manufactured by drying or hot-pressing a cellulosic fiber-containing mat to consolidate said mat into a unitary blank, cutting the blank to a size larger than interior dimensions of a closed mold in each of its three dimensions and with at least two generally shaped or profiled edge surfaces disposed between a top surface and a bottom surface of the blank. The cut blank is then molded at a temperature of at least 200.degree. F. for a period of time sufficient to permanently transfer the interior shape and design of the mold cavity to every surface of the blank.

Abstract: A cellulosic fiber containing board is molded at a temperature of at least 525.degree. F. to provide a relatively high density skin on at least one surface. A fibrous composition, including cellulosic fibers, is consolidated to form a consolidated blank. The consolidated blank is then cut to a shape larger in at least two of its three dimensions than corresponding dimensions of a mold cavity when said mold is in a closed position. Urea is then included in at least a surface layer of fibers of the blank in an amount of at least 5% based on the dry weight of the fibers contacted with urea, and thereafter the cut blank is molded to form a contoured product having a skin on at least one surface thereof. The skin is formed by hot-pressing a consolidated cellulosic fiber-containing board including urea in at least its surface fibers, at a temperature of at least 525.degree. F. The composition of the skin has not been determined but is different than the composition of cellulosic material thereunder.

Abstract: A cellulosic fiber containing board is molded at a temperature of at least 525.degree. F. to provide a relatively high density skin on at least one surface.A fibrous composition, including cellulosic fibers, is consolidated to form a blank having a density of less than 35 pounds/cubic foot. The blank is then cut to a shape larger in at least two of its three dimensions than corresponding dimensions of a mold cavity when said mold is in a closed position.Urea is then included in at least a surface layer of fibers of the blank in an amount of at least 5% based on the dry weight of the fibers contacted with urea, and thereafter the cut blank is molded to form a contoured product having a skin on at least one surface thereof, the skin defined by a thickness of material on said surface of said product having a density greater than the material on which the skin is formed.

Abstract: A fiberboard is manufactured having relatively high density skins on a relatively low density core by including urea in at least the surface fibers of a consolidated mat, having a density of less than 35 pounds per cubic foot, and then hot-pressing the consolidated mat at a temperature of at least 525.degree. F. to form a board having high density surface skins.

Abstract: Six-sided furniture parts are manufactured by pressing a cellulosic fiber-containing mat to consolidate said mat into a unitary blank, cutting the blank to a size larger than interior dimensions of a closed mold in every dimension and with two to four generally shaped or profiled edges disposed between a top surface and a bottom surface of the blank. The cut blank is then molded at a temperature of at least 500.degree. F. for a period of time sufficient to permanently transfer the interior shape and design of the mold cavity to every surface of the blank.

Abstract: A fiberboard is manufactured having relatively high density skins on a relatively low density core by including a skin forming chemical in at least the surface fibers of a consolidated mat, having a density of less than 35 pounds per cubic foot, and then hot-pressing the consolidated mat at a temperature of at least 525.degree. F. to form a board having high density surface skins.

Abstract: A mineral wool board is manufactured having relatively high density skins by including urea in at least the surface fibers of a consolidated mineral wool fiberboard containing cellulosic fibers and/or starch and then hot-pressing the consolidated board at a temperature of at least 525.degree. F. to form a board having high density surface skins.