Abstract: Methods of selectively depositing a carbon-containing layer are described. Exemplary processing methods may include flowing a first precursor over a substrate comprising a metal surface and a non-metal surface to form a first portion of an initial carbon-containing film on the metal surface. The methods may include removing a first precursor effluent from the substrate. A second precursor may then be flowed over the substrate to react with the first portion of the initial carbon-containing layer. The methods may include removing a second precursor effluent from the substrate. The methods may include pre-treating the metal surface of the substrate to form a metal oxide surface on the metal surface.

Abstract: The present application relates to oligonucleotides (e.g., antisense oligonucleotides such as gapmers) designed to target DMPK RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DMPK.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles.

Abstract: Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes comprising an oligonucleotide (e.g., useful for targeting DMPK) covalently linked to an antibody (e.g., anti-TfR1 antibody).

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Provided herein are compositions and methods useful for the detection of MTB. In particular, provided herein are kits, reagents, reaction mixtures, and methods involving such for nucleic acid amplification and detection procedures, which specifically and sensitively detect MTB in samples.

Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder includes a first chamber, a second chamber, at least one inlet tube structured and configured to allow ambient air to enter the first chamber, at least one flow tube structured and configured to allow air to pass from the first chamber to the second chamber, and a blower structured and configured to produce a flow of air at positive pressure. The blower is positioned in the first chamber and structured and configured to receive air from the second chamber. The blower includes a housing structured and configured to sealingly separate air flow through an interior of the housing from the first chamber. The at least one inlet tube is axially spaced from the at least one flow tube.

Abstract: A method for producing a neutrons includes triggering a raising or a lowering of a temperature of a pyroelectric crystal of less than about 40° C. to produce a voltage of negative polarity of at least ?100 keV on a surface of a deuterated or tritiated target coupled thereto. A deuterium ion source is pulsed to produce a deuterium ion beam. The accelerating of the deuterium ion beam is achieved by accelerating voltage of the pyroelectric crystal toward the deuterated or tritiated target to produce neutrons. Furthermore, the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source are coupled to a common support. The method also includes throwing the common support housing the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source near an unknown threat for identification thereof.

Abstract: A physical vapor deposition processing chamber is described. The processing chamber includes a target backing plate in a top portion of the processing chamber, a substrate support in a bottom portion of the processing chamber, a deposition ring positioned at an outer periphery of the substrate support and a shield. The substrate support has a support surface spaced a distance from the target backing plate to form a process cavity. The shield forms an outer bound of the process cavity. In-chamber cleaning methods are also described. In an embodiment, the method includes closing a bottom gas flow path of a processing chamber to a process cavity, flowing an inert gas from the bottom gas flow path, flowing a reactant into the process cavity through an opening in the shield, and evacuating the reaction gas from the process cavity.

Abstract: Systems and methods for privacy-preserving enablement of connections within organizations are disclosed. In one embodiment, a method may include (1) receiving, at a server comprising a computer processor, an identification of a target to contact from a requester in an organization; (2) the computer processor identifying, in a connection database, at least one user within the organization having a connection with the target; (3) the computer processor communicating anonymized information representing the at least one user having the connection and a relationship-strength score for the connection; (4) the computer processor communicating a request for introduction assistance to the at least one user; (5) the computer processor receiving acceptance of the request for introductory assistance from the at least one user; and (6) the computer processor identifying the at least one that accepted the request to the requester.

Abstract: The invention relates to an engine that generates client profile-based sales decisions. An embodiment of the present invention is directed to providing new insights to strengthen opportunities to provide additional services to clients. The system is directed to developing client profile-based recommendations for trade ideas. For example, the innovative engine may recommend opportunities, such as new trade ideas, to a particular client based upon the client's transaction history, as well as other data and factors. The system may generate an account profile based upon client data and use this profile to score a potential new trade idea.

Abstract: Techniques for recording and replay of a live conference while still attending the live conference are described. A conferencing system includes a user interface generator, a live conference processing module, and a replay processing module. The user interface generator is configured to generate a user interface that includes a replay control panel and one or more output panels. The live conference processing module is configured to extract information included in received conferencing data that is associated with one or more conferencing modalities, and to display the information in the one or more output panels in a live manner (e.g., as a live conference). The replay processing module is configured to enable information associated with the one or more conferencing modalities corresponding to a time of the conference session prior to live to be presented at a desired rate, possibly different from the real-time rate.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: Systems and methods for hierarchical dual-dynamic exception management are disclosed. In one embodiment, the system and method may provide: (1) hierarchical exception modelling, metric algorithms and aggregation; (2) node level exception metric algorithm and high-level status algorithm calculation; (3) node level investigation via “explain” of exception factors (e.g., focusing an analyst on a particular issue); (4) node level tracking workflow management through ability to add commentary, multiple-person signoff, and high-level status calculation overrides; (5) visibility, auditable compliance reporting; (6) dashboard for internal operational analysts/managers with full investigation view; (7) dashboard for external clients with sub views; (8) generic data interface to existing workflow management system; and (9) machine learning component such that the exception metric can be intelligently re-adjusted (for example, if there are too many false positives then make the thresholds more forgiving).

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.

Abstract: Facilitating presentation of a view of the virtual space in a first view mode to users through client computing platforms and in a second view mode to users through client computing platforms. The first view mode and second view mode causing the views of the virtual space to have different view characteristics. Different inputs are effectuated when in the different view modes to facilitate interaction by the user with the virtual space in different manners.

Abstract: Techniques for recording and replay of a live conference while still attending the live conference are described. A conferencing system includes a user interface generator, a live conference processing module, and a replay processing module. The user interface generator is configured to generate a user interface that includes a replay control panel and one or more output panels. The live conference processing module is configured to extract information included in received conferencing data that is associated with one or more conferencing modalities, and to display the information in the one or more output panels in a live manner (e.g., as a live conference). The replay processing module is configured to enable information associated with the one or more conferencing modalities corresponding to a time of the conference session prior to live to be presented at a desired rate, possibly different from the real-time rate.

Abstract: The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist reservoir.