Abstract: Disclosed are example embodiments of an endovascular coil having a twisted figure 8 shape. The endovascular coil includes: a first loop; a second loop; and an inflection region where a portion of the first loop transitions into a portion of the second loop. The second loop is rotated about an axis parallel to the longitudinal axis of the first loop to create the twisted figure 8 shape. The twist adds more randomness and variability to the filling behavior of the endovascular coil. The added randomness and variability enables the twisted figure 8 coil to better fill the void of irregular-shaped aneurysms than other conventional embolic coils.

Abstract: The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.

Abstract: The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.

Abstract: The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.

Abstract: A unique method and coatings are provided to promote/allow early stage tissue encapsulation/endothelization of medical devices while effectively controlling excessive tissue buildup by eluting antiproliferative therapeutic agent within a body of a patient. The method involves using a therapeutic agent that suppresses excessive extracellular matrix proliferation and allows/promotes thin tissue healing/encapsulation/endothelization of the device. Optimized timing of onset of elution to match onset of excessive extracellular matrix proliferation for maximum effectiveness is achieved by delay barrier with biochemical switch.

Abstract: The present invention involves an expandable element with an outer sticky surface. The expandable element may be in the form of a balloon with deflated and inflated configurations. The expandable element serves to both dilate a lumen in a blood vessel thereby opening it and to exert force upon the sticky surface in order to press it into apposition against a vessel wall. The outer sticky surface may be provided directly upon the expandable element or on a separate outer sheath that conforms to and follows the contours of the expandable element. The sticky surface may take the form of a biochemical composition and/or a mechanically abrasive structure such as microhooks, hairs, mesh netting, etc. Optionally, additional expandable elements may be provided proximal and distal to the main element to occlude blood flow on either side of a lesion in order to better trap emboli for collection.

Abstract: The present invention provides a PreStent comprising a sheath and frame designed for preparing a vessel passageway for the subsequent delivery of a stent. The PreStent can be self-expanding or balloon-expandable. Also provided is a supporting system for delivering the PreStent safely. The supporting system includes a delivery catheter, one or more occlusion balloon, optionally one or more dilation balloon, and a retention sheath for the self-expanding type of PreStent. The PreStent of the present invention is flexible for use with a variety of stent and guidewire models such that it can easily be incorporated with existing devices to improve stenting procedures.