Abstract: In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

Abstract: The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

Abstract: In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

Abstract: A fluorescence histo-tomography (FHT) method may include capturing, using an imaging device positioned with respect to a chamber of a slicing apparatus, images of a block face of a specimen retained within the chamber. The images may be captured in the visible and infrared or near-infrared spectrum. The method may include co-registering the images to form a combined image, and providing the combined image to an electronic display. In some implementations, the method may include positioning the imaging device away from the chamber, operating the slicing apparatus to expose a second block face of the specimen, and repositioning the imaging device with respect to the chamber.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Abstract: In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

Abstract: The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

Abstract: The instant invention provides near-infrared fluorescent nerve contrast agents and methods of using them.

Abstract: In one embodiment, an imaging system illuminates a surface of tissue with one or more spots of near-infrared (NIR) light within a field of view of a camera of the imaging system. The imaging system captures an image of the one or more spots of NIR light within the field of view of the camera of the imaging system. The imaging system calculates, for each of the one or more spots of NIR light in the captured image, a spot diameter, spot position, or spot shape in the captured image. The imaging system determines a distance between the imaging system and the surface of tissue, based on the calculated spot diameter, spot position, or spot shape of the one or more spots of NIR light in the captured image. The imaging system provides data indicative of the determined distance between the imaging system and the surface of tissue to an electronic display.

Abstract: An imaging system illuminates a portion of a plant with a light source comprising a near-infrared (NIR) light source to cause fluorescent emission by a fluorescent imaging agent absorbed by the plant and distributed within the plant via transpiration. The imaging system receives the fluorescent emission from the illuminated portion of the plant. The imaging system generates a fluorescent image of the portion of the plant from the received fluorescent emission. The imaging system displays, on a display device of the imaging system, the fluorescent image. Based on the fluorescent image, a determination that the plant has a disease or injury can be made.

Abstract: In one aspect, a visible light sensor of an imaging system captures a visible light image of a subject in which a fluorophore is present. The fluorophore has fluorescence emissions in the visible spectrum and in the near-infrared (NIR) spectrum. An NIR sensor of the imaging system captures an NIR image of the subject in which the fluorophore is present. The imaging system forms a combined image of the visible light image and the NIR image, in part by masking pixels of the visible light image with pixels of the NIR image that are associated with the fluorescence emission of the fluorophore in the NIR spectrum. The imaging system provides the combined image to an electronic display for display.

Abstract: In one embodiment, an imaging device determines color information for a portion of organic tissue from one or more captured color images of the tissue. The imaging device identifies one or more optical properties of the portion of tissue based on the determined color information. The imaging device adjusts fluorescence data captured via one or more fluorescence images of the portion of organic tissue. The imaging device provides the adjusted fluorescence data to an electronic display for display.

Abstract: In one embodiment, a visible light sensor of an imaging system captures a visible light image of a subject in which a fluorophore is present. The fluorophore has fluorescence emissions in the visible spectrum and in the near-infrared (NIR) spectrum. An NIR sensor of the imaging system captures an NIR image of the subject in which the fluorophore is present. The imaging system forms a combined image of the visible light image and the NIR image, in part by masking pixels of the visible light image with pixels of the NIR image that are associated with the fluorescence emission of the fluorophore in the NIR spectrum. The imaging system provides the combined image to an electronic display for display.

Abstract: In one embodiment, a ball joint comprises a base that includes a first surface that defines a hemispherical chamber and an electromagnet located internal to the base. The ball joint further comprises an armature plate fastened to the first surface of the housing and defining an aperture that extends through the armature plate towards the hemispherical chamber. The ball joint further comprises a shaft that extends through the aperture of the armature plate and has a rounded end that engages the hemispherical chamber of the housing. Powering the electromagnet draws the armature plate towards the first surface to provide compressive force to the shaft and prevents movement of the shaft.

Abstract: The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.

Abstract: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.

Abstract: In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Abstract: An imaging system illuminates a portion of a plant with a light source comprising a near-infrared (NIR) light source to cause fluorescent emission by a fluorescent imaging agent absorbed by the plant and distributed within the plant via transpiration. The imaging system receives the fluorescent emission from the illuminated portion of the plant. The imaging system generates a fluorescent image of the portion of the plant from the received fluorescent emission. The imaging system displays, on a display device of the imaging system, the fluorescent image. Based on the fluorescent image, a determination that the plant has a disease or injury can be made.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes a housing, a fluorescence camera located within the housing, a white light camera located within the housing, and a fluorescence light source located within the housing. The FHT system further includes a support mount configured to support the housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.