Patents by Inventor John W. Hadden

John W. Hadden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives
    Patent number: 4510144
    Abstract: There are prepared compounds of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SH,R is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immuno-modulating activity.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: April 9, 1985
    Assignee: Newport Pharmaceuticals International
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • Purine-dihydrothiazoles
    Patent number: 4387226
    Abstract: There are prepared compound of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, lower alkyl ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SHR is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immunomodulating activity.
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: June 7, 1983
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute For Cancer Research
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
    Patent number: 4221909
    Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: September 9, 1980
    Assignees: Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Instit. for Cancer Res.
    Inventors: Lionel N. Simon, John W. Hadden
  • Method of imparting immunomodulating and antiviral activity
    Patent number: 4221794
    Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: September 9, 1980
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Lionel N. Simon, John W. Hadden