Abstract: Methods and apparatus are provided for the continuous and rapid production of a plurality of flexible packages containing a non-solid substance such as an ointment, by continuously forming and vacuum sealing the packages from two webs of material in the nip of cooperating roller surfaces. The packages each contain a precise quantity of medication which may be, for example, the kind of medication which is self-administered by the user by transdermal application. The method and apparatus herein joins together two specially prepared webs of material continuously drawn from supply rolls while at the same time incorporating and vacuum sealing a desired quantity of the medication therebetween.