Patents by Inventor John Wallace Parce
John Wallace Parce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210148885Abstract: The present disclosure includes a nanopore array devices that include a chip with an array of nanopore components for performing high-throughput and multiplexed assays. Aspects of the present disclosure include methods of screening drug targets and performing multiplexed assays using the nanopore chip of the devices and systems described in the present disclosure. Aspects of the present disclosure further include methods for performing single cell analysis using the devices and systems of the present disclosure.Type: ApplicationFiled: November 18, 2020Publication date: May 20, 2021Inventors: William B. Dunbar, Xu Liu, Philip Edward Zimny, John Wallace Parce
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Publication number: 20120220486Abstract: The present teachings relate to methods, systems, and apparatus for low cost label-free assay detection. The present teachings, in a variety of embodiments, employ opposing forces to detect signals which depend on the number of charges on and/or the size of a particle. The particle, which can be subjected to opposing forces, can have specific capture probes at its surface. As analytes of interest are captured by the particle, the number of charges on the particle surface and/or the size of the particle is changed. A particle parameter or kinematic property such as the position, velocity, acceleration or force of/on the particle can be measured, and results obtained relating, for example, to the present, absence, quantity, and such, of one or more analytes of interest. Various embodiments are described for efficient, high throughput assays of samples potentially including one or more analytes of interest, such as bioanalytes.Type: ApplicationFiled: October 31, 2010Publication date: August 30, 2012Applicant: CAERUS MOLECULAR DIAGNOSTICS INCORPORATEDInventors: Javier Farinas, Andrea Chow, John Wallace Parce
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Publication number: 20110059864Abstract: The present teachings relate to systems, methods, and the like, for analyzing biological polymers, by use of opposing forces. Among other things, the present teachings can be used to determine sequence information, such as in genetic sequencing and genotyping applications. Various embodiments are described for efficient, high throughput sequencing of nucleic-acid molecules, such as DNA. Various embodiments are described wherein nucleic-acid sequence information is determined without the need or use of extrinsic labels. As well various embodiments of methods, systems, and the like, are described, which can provide long and accurate read lengths for low-cost nucleic acid sequencing.Type: ApplicationFiled: September 7, 2010Publication date: March 10, 2011Applicant: CAERUS MOLECULAR DIAGNOSTICS INCORPORATEDInventors: Javier Farinas, Andrea Chow, John Wallace Parce
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Publication number: 20100112588Abstract: Methods for highly parallel Sanger sequencing are discussed. In particular, provided herein are methods using particles to clonally amplify templates and to introduce the amplified nucleic acids into many parallel channels with a single template per channel. Once in the channels, the nucleic acids are separated by size using electrophoresis to produce long read length sequencing information. Methods involving optical detection of the size-separated nucleic acids and analysis of the resulting electropherograms to yield the sequences are disclosed.Type: ApplicationFiled: November 3, 2009Publication date: May 6, 2010Applicant: CAERUS MOLECULAR DIAGNOSTICS, INC.Inventors: Javier Farinas, Andrea Chow, John Wallace Parce
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Patent number: 7285411Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: GrantFiled: November 22, 2000Date of Patent: October 23, 2007Assignee: Caliper Life Sciences, Inc.Inventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Patent number: 7238323Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: GrantFiled: December 5, 2002Date of Patent: July 3, 2007Assignee: Caliper Life Sciences, Inc.Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Patent number: 6849411Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: GrantFiled: November 22, 2002Date of Patent: February 1, 2005Assignee: Caliper Life Sciences, Inc.Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Patent number: 6787088Abstract: Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.Type: GrantFiled: December 10, 2002Date of Patent: September 7, 2004Assignee: Caliper Life Science, Inc.Inventors: John Wallace Parce, Michael R. Knapp, Calvin Y. H. Chow, Luc J. Bousse
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Patent number: 6703205Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.Type: GrantFiled: March 19, 2002Date of Patent: March 9, 2004Assignee: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Cohen, Steven A. Sundberg, John Wallace Parce
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Patent number: 6670133Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: GrantFiled: July 17, 2002Date of Patent: December 30, 2003Assignee: Caliper Technologies Corp.Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Publication number: 20030165960Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.Type: ApplicationFiled: February 5, 2003Publication date: September 4, 2003Applicant: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Cohen, Steven A. Sundberg, John Wallace Parce
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Patent number: 6613512Abstract: Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.Type: GrantFiled: December 5, 2000Date of Patent: September 2, 2003Assignee: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Claudia B. Jaffe, Steven A. Sunberg, John Wallace Parce
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Publication number: 20030148922Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: ApplicationFiled: July 17, 2002Publication date: August 7, 2003Applicant: Caliper Technologies Corp.Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Patent number: 6582576Abstract: The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems for controlling the performance of the processes carried out within the device, e.g., controlling internal fluid transport and direction, monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.Type: GrantFiled: October 7, 1999Date of Patent: June 24, 2003Assignee: Caliper Technologies Corp.Inventors: Calvin Y. H. Chow, John Wallace Parce, Richard J. McReynolds, Colin B. Kennedy, Luc J. Bousse
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Publication number: 20030104466Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: ApplicationFiled: December 5, 2002Publication date: June 5, 2003Applicant: Caliper Technologies CorporationInventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Patent number: 6568910Abstract: The present invention generally provides a micropump that utilizes electroosmotic pumping of fluid in one channel or region to generate a pressure based flow of material in a connected channel, where the connected channel has substantially no electroosmotic flow generated. Such pumps have a variety of applications, and are particularly useful in those situations where the application for which the pump is to be used prohibits the application of electric fields to the channel in which fluid flow is desired, or where pressure based flow is particularly desirable.Type: GrantFiled: April 2, 2002Date of Patent: May 27, 2003Assignee: Caliper Technologies Corp.Inventor: John Wallace Parce
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Publication number: 20030089606Abstract: Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.Type: ApplicationFiled: December 10, 2002Publication date: May 15, 2003Applicant: Caliper Technologies Corp.Inventors: John Wallace Parce, Michael R. Knapp, Calvin Y.H. Chow, Luc J. Bousse
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Publication number: 20030087300Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: ApplicationFiled: November 22, 2002Publication date: May 8, 2003Applicant: Caliper Technologies Corp.Inventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Patent number: 6558944Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: GrantFiled: July 1, 1999Date of Patent: May 6, 2003Assignee: Caliper Technologies Corp.Inventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Publication number: 20030077634Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: ApplicationFiled: August 27, 2002Publication date: April 24, 2003Applicant: Caliper Technologies CorporationInventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse