Abstract: The present invention relates to the field of tape drives, tape transport, tape heads and tape head suspension. More particularly, the present invention is related to magnetic tape data storage and tape recorders that include components designed to minimize or eliminate head-to-tape contact to reduce or eliminate wear and contamination of tape drive heads. Methods and apparatus of the present invention may dynamically control the head-to-media spacing by moving locations of magnetic heads relative to a tape. Such apparatus may include components designed to minimize magnetic spacing. This may be accomplished using actuators that move the magnetic heads, that move the tape, or that move both the magnetic heads and the tape. This may include supporting a back surface of the tape. Alternatively, or additionally, the movement of the tape past the magnetic heads may be performed using mechanisms that contact and drive the back surface of the tape.

Abstract: A system enables tool to process remote log files as if the log files were located locally. The system relies on technology, such a file system in user space (FUSE), to add log file search results to the local file system. In some embodiments, the log file search results are associated with virtual files in the local file system. A remote data store system communicates with the local system to provide the search results in response to a search query.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Processes for producing 2,5-dichlorophenol and 3,6-dichloro-2-methoxybenzoic acid are described. Various processes for isomerizing 2,4-dichlorophenol over a zeolite catalyst to form 2,5-dichlorophenol are provided. Processes for preparing 2,5-dichlorophenol including hydroxylating 1,4-dichlorobenzene are also described. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.

Abstract: Applications may be created and registered to an online ecosystem and then execute within individual web applications such as productivity applications, communication applications, collaboration applications, and so on. These non-native applications may be enabled to interact with files and provide custom experiences for a user. The applications may also be enabled to interact with additional information discovered about the user within the ecosystem to provide custom experiences. The applications may further be enabled to create custom workflows to allow users to accomplish new tasks.

Abstract: A method for generating a graphical performance display, including: receiving performance measure data; generating a graphical rectangular plot, having a first side indicating a prevalence value, a second side indicating a sensitivity value, and third side indicating a specificity value, wherein the second and third sides are opposite one another and a fourth side is opposite the first side; drawing a prevalence line perpendicular to the first side between the first side and the fourth side based upon a prevalence value in the performance measure data; drawing a sensitivity line perpendicular to the second side between the second side and the prevalence line based upon a sensitivity value in the performance measure data; and drawing a specificity line perpendicular to the third side between the third side and the prevalence line based upon a sensitivity value in the performance measure data.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: The invention provides methods of reducing fouling of ultrafiltration membranes in processes wherein virus particles are removed from aqueous solutions comprising virus particles and at least one protein by adding a surfactant or non-surfactant, non-ionic agent to the aqueous solution prior to filtration. The invention also provides methods to dissociate protein aggregates or to reduce the formation of protein aggregates by adding a surfactant or non-surfactant, non-ionic agent to the protein solution.

Abstract: A portable electronic device determines a battery available power for the device's battery and manages device power usage based upon the battery available power. The device includes a battery and a controller. The controller is configured to receive a first voltage value for the battery at a first time, a first current value for the battery, a second voltage value for the battery at a second time, and a second current value for the battery. It is determined that a time difference between the first time and the second time exceeds a predetermined time threshold. An estimated resistance of the battery is determined based at least on a first difference between the first current value and the second current value and a second difference between the first voltage value and the second voltage value. Real-time power usage of the device is controlled based on the estimated resistance of the battery.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A method includes receiving a signal associated with an electronic meeting invitation for users to attend the electronic meeting. The users include members of an organization and at least one nonmember of the organization. Responsive to receiving the signal, an online collaborative team is automatically created within an online chat environment. The team members of the online collaborative team include the members and the at least one nonmember. In some embodiments, an online collaborative team account is automatically created for the at least one nonmember responsive to determining that the at least one nonmember has no online collaborative team account.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: A system enables tool to process remote log files as if the log files were located locally. The system relies on technology, such a file system in user space (FUSE), to add log file search results to the local file system. In some embodiments, the log file search results are associated with virtual files in the local file system. A remote data store system communicates with the local system to provide the search results in response to a search query.

Abstract: Processes for producing 2,5-dichlorophenol and 3,6-dichloro-2-methoxybenzoic acid are described. Various processes for isomerizing 2,4-dichlorophenol over a zeolite catalyst to form 2,5-dichlorophenol are provided. Processes for preparing 2,5-dichlorophenol including hydroxylating 1,4-dichlorobenzene are also described. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.