Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

Abstract: A railroad locomotive monitoring system configuration system for a plurality of trains comprising: a monitoring system, and an on-board computer programmed or configured to: determine or receive railroad locomotive data; determine or receive railroad operation data; determine or receive configuration data; and based at least partially on at least a portion of the railroad locomotive data, at least a portion of the railroad operation data, and at least a portion of the configuration data, automatically configure at least one setting of the at least one component of the monitoring system.

Abstract: A knife switch assembly including a pair of hinged contact knives, arranged in parallel, and moveable between at least two positions. An operator device for moving the pair of contact knives between the at least two positions, and a guide member located between the two contact knives, having two projecting side parts, each projecting side part extending along at least part of a respective side of each contact knife, which side faces a corresponding side of the other contact knife.

Abstract: A knife switch assembly including a pair of hinged contact knives, arranged in parallel, and moveable between at least two positions. An operator device for moving the pair of contact knives between the at least two positions, and a guide member located between the two contact knives, having two projecting side parts, each projecting side part extending along at least part of a respective side of each contact knife, which side faces a corresponding side of the other contact knife.

Abstract: A joint comprising: a first component having a face and a bore defined by a bore wall; a second component; a fastener joining the first component to the second component, the fastener comprising a head and a shaft protruding from the head; and a polysulphide gasket comprising a ring which is compressed between the head of the fastener and the face of the first component; and a collar between the shaft of the fastener and the bore wall. The gasket comprises a ring of sealing material surrounding a hole for receiving a fastener, the sealing material comprising an at least partially cured polysulphide sealant. The gasket has a region of increased thickness positioned towards the inner periphery of the ring which flows to form the collar.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: A method of patterning a combined layer of an electrically-conductive film, such as indium-tin-oxide (ITO), that is disposed on a flexible substrate includes bending the combined layer about a radius of curvature. The combined layer is initially bent in a first direction so that the electrically-conducive film is distal to the radius of curvature, so as to form initial dielectric lines in the electrically-conductive film. The combined layer is then bent in another direction so that the electrically-conductive film is proximate to the radius of curvature to further enhance the dielectric performance of the initial dielectric lines. The dielectric lines electrically isolate a portion of the electrically-conductive film that is disposed therebetween, to form an electrically conductive electrode.

Abstract: A sealing member for forming a seal in an aircraft, the sealing member comprising: a sealing material; and a stiffening element which provides structural support to the sealing material and comprises a material with a glass transition temperature below +50° C. The stiffening element is relatively flexible when the aircraft is at low altitude (high temperature) but becomes relatively stiff (increasing resistance to seal flutter) when the aircraft is at cruise altitude (low temperature).

Abstract: A foldable seal comprising an elastomeric seal substrate and at least one molded-in stiffener plate embedded within the seal substrate. Also, a method of manufacturing the seal.

Abstract: Disclosed herein are methods for improving detection and monitoring of human diseases. The methods can be used to provide spatial and/or developmental localization of the source of each differential mutation within the body. The methods can also be used to generate a mutation map of a subject. And the mutation map can be used to monitoring state(s) of health of one or more tissues of a subject.

Abstract: A hydraulically damped mounting device (10) having a flow limiting element (42), such as a resilient diaphragm, in a switchable auxiliary passageway (36) that is in fluid communication with its working chamber (22). The switchable auxiliary passageway corresponds to an additional fluid mass that can be switched into and out of communication with the working chamber to control the vibration characteristics of the device.

Abstract: A method for managing a plurality of files in a communication network having a plurality of clients includes a server receiving (502) metadata associated with a secured file stored in a virtual data drive of a first client. The server also receives (504) data segments associated with the file from the virtual data drive of the first client. The server stores the metadata and data segments associated with the file at the server. The server generates (506) a first representation of the file based on the received metadata and data segments associated with the file and sends (508) the first representation of the file to the plurality of clients. Next, the server receives (510) a request from a second client for at least one data segment of the file. The server authenticates the request based on a plurality of access rights of a user of the second client and sends (512) the at least one data segment of the file to the second client when the request is authenticated.

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: A lift truck includes an operator compartment and a pair of forks extending away from said operator compartment in a forward direction. A pair of mast columns are interposed between the operator compartment and the forks. Components mounted on at least one of the mast columns are arranged to fall within a viewing shadow so as not to obstruct the operator's field of view.

Abstract: A getter composition suitable for gettering hydrogen comprises a first metal oxide and a second metal oxide, said first metal oxide being more readily reducible in hydrogen at temperatures between 0° C. and 100° C. than said second metal oxide.

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

Abstract: The disclosure is related to systems and methods for temperature-based device operation. In one example, a device may include a first memory and a temperature detection module adapted to measure a temperature of the device and modify a data storage behavior of the first memory based on the temperature. The device may further comprise a second memory, and the temperature detection module may direct that data be written to the first memory less frequently, and be written to the second memory more frequently when a threshold temperature is exceeded. The temperature detection module may also implement operating limitations for the device when a threshold temperature is exceeded, such as restricting execution of background diagnostics or implementing other operating limitations. In some embodiments, other environmental factors such as humidity, altitude, air pressure, physical shock, or other factors may be monitored and the device operation may be modified based on those factors.