Patents by Inventor John William Lowenthal
John William Lowenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220106574Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: October 12, 2021Publication date: April 7, 2022Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Patent number: 11174466Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: GrantFiled: November 23, 2016Date of Patent: November 16, 2021Assignees: Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Patent number: 11118166Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.Type: GrantFiled: January 25, 2019Date of Patent: September 14, 2021Assignees: University of Georgia Research Foundation, Inc.Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Patent number: 10907133Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.Type: GrantFiled: November 23, 2016Date of Patent: February 2, 2021Assignees: Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Patent number: 10626379Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: GrantFiled: January 25, 2019Date of Patent: April 21, 2020Assignees: Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Publication number: 20190322989Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: January 25, 2019Publication date: October 24, 2019Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Publication number: 20190203186Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: January 25, 2019Publication date: July 4, 2019Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Publication number: 20180340154Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Publication number: 20180340153Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
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Patent number: 9051369Abstract: The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon-? (IFN-?) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN-? protein or nucleic acid functionality.Type: GrantFiled: September 19, 2008Date of Patent: June 9, 2015Assignees: Commonwealth Scientific and Industrial Research Organisation, Australian Poultry CRCInventors: John William Lowenthal, Andrew Gerard D. Bean, Adam Joseph Karpala
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Publication number: 20130067606Abstract: The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.Type: ApplicationFiled: September 4, 2012Publication date: March 14, 2013Applicants: Commonwealth Scientific and Industrial Research Organisation, AUSTRALIAN POULTRY CRC PTY LTDInventors: Timothy James DORAN, Robert John MOORE, John William LOWENTHAL, Craig Allen SMITH, Andrew Henrik SINCLAIR
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Publication number: 20120227119Abstract: The present invention relates to nucleic acids and methods for modulating the sex of avians. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to increase the production of female birds.Type: ApplicationFiled: December 16, 2009Publication date: September 6, 2012Applicants: Australian Poultry CRC Pty Ltd, Commonwealth Scientific and Industrial Research OrganisationInventors: Timothy James Doran, Robert John Moore, John William Lowenthal, Craig Smith, Andrew Henrik Sinclair
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Publication number: 20120198578Abstract: The present invention relates to an assay for detecting virus, in particular an assay for detecting viral replication in a tissue sample. The invention also relates to methods of determining the susceptibility of an animal to a virus, and methods of breeding animals with decreased susceptibility to a virus.Type: ApplicationFiled: June 18, 2010Publication date: August 2, 2012Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: John William Lowenthal, Timothy James Doran, Scott Geoffrey Tyack, Terry Glenn Wise, Scott McLeod
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Publication number: 20120084873Abstract: The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expression or activity of the DMRT1 gene or protein is modulated to produce animals with displaying a phenotype sex that differs from their genotype.Type: ApplicationFiled: February 8, 2010Publication date: April 5, 2012Inventors: Andrew Sinclair, Craig Smith, Timothy James Doran, Robert John Moore, John William Lowenthal
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Publication number: 20110209231Abstract: The present invention relates to nucleic acid molecules comprising a double-stranded region, and nucleic acid constructs encoding therfor, that are useful for the treatment and/or prevention of influenza. In particular, the present invention relates to nucleic acid constructs encoding a double stranded RNA molecule(s) that can be used to produce transgenic poultry, for example chickens, such that they are at least less susceptible to an avian influenza infection. Also provided are nucleic acid molecules comprising a double-stranded region that can be used as a therapeutic to treat and/or prevent, for example, avian influenza in poultry.Type: ApplicationFiled: May 16, 2008Publication date: August 25, 2011Inventors: Timothy James Doran, James Climie McKay, Robert John Moore, John William Lowenthal, Scott Geoffrey Tyack
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Publication number: 20110038834Abstract: The present invention relates generally to novel recombinant polypeptides having avian cytokine properties and to genetic sequences encoding same. More particularly, the present invention is directed to recombinant avian Type III interferon polypeptides, and genetic sequences encoding same, together with cellular expression systems and uses for same. Even more particularly, the present invention is directed to avian interferon-? (IFN-?) and functional derivatives, homologues and fragments thereof and to methods of use thereof. The molecules and cells of the present invention are useful in a wide range of applications including, but not limited to, providing a means for the treatment and prophylaxis of disease conditions, in particular avian disease conditions, or for use as an immune response modulator. Also provided are diagnostic means for screening for immune response and screening means for identifying modulators of IFN-? protein or nucleic acid functionality.Type: ApplicationFiled: September 19, 2008Publication date: February 17, 2011Applicant: AUSTRALIAN POULTRY CRC PTY LTDInventors: John William Lowenthal, Andrew Gerard D. Bean, Adam Joseph Karpala
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Publication number: 20100306869Abstract: The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.Type: ApplicationFiled: June 12, 2008Publication date: December 2, 2010Applicants: COMMWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION, AUSTRALIAN POULTRY CRC PTY LTDInventors: Timothy James Doran, Robert John Moore, John William Lowenthal
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Patent number: 6083724Abstract: A cDNA corresponding to the chicken interferon-.gamma. (IFN-.gamma.) gene has been isolated. The invention thus provides avian IFN-.gamma. polypeptides, nucleic acids encoding them, and their recombinant production. The nucleic acids and polypeptides are useful as therapeutic agents and as adjuvants for the treatment of birds.Type: GrantFiled: April 25, 1997Date of Patent: July 4, 2000Assignee: Commonwealth Scientific and Industrial Research OrganizationInventors: John William Lowenthal, Jennifer Joy York, Terri Ellen O'Neil, Stephen Rhodes, Matthew Robert Digby