Patents by Inventor John Wozney

John Wozney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Porous carrier matrix
    Patent number: 11529438
    Abstract: Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: December 20, 2022
    Assignee: BIOVENTUS, LLC
    Inventors: Christopher Wilson, Eric Vanderploeg, Cheryl Lee, Chase Davis, Howard Seeherman, John Wozney
  • Systems and methods for improved delivery of osteoinductive molecules in bone repair
    Patent number: 11452760
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: September 27, 2022
    Assignee: BIOVENTUS, LLC
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • Protein delivery with porous metallic structure
    Patent number: 10646347
    Abstract: Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: May 12, 2020
    Assignee: Bioventus LLC.
    Inventors: Jeffrey Welch, Eric Vanderploeg, Christopher Wilson, John Wozney
  • POROUS CARRIER MATRIX
    Publication number: 20190388585
    Abstract: Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Inventors: Christopher WILSON, Eric VANDERPLOEG, Cheryl LEE, Chase DAVIS, Howard SEEHERMAN, John WOZNEY
  • Designer osteogenic proteins
    Patent number: 10370424
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: August 6, 2019
    Assignee: Wyeth, LLC.
    Inventors: John Wozney, Howard Seeherman, Christopher Todd Brown
  • Matrix for enhanced delivery of osteoinductive molecules in bone repair
    Patent number: 10300172
    Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 28, 2019
    Assignee: Bioventus, LLC.
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
  • SYSTEMS AND METHODS FOR IMPROVED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR
    Publication number: 20190070256
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Application
    Filed: October 4, 2018
    Publication date: March 7, 2019
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • Systems and methods for improved delivery of osteoinductive molecules in bone repair
    Patent number: 10130678
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: November 20, 2018
    Assignee: Bioventus, LLC.
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • DESIGNER OSTEOGENIC PROTEINS
    Publication number: 20180072787
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: November 22, 2017
    Publication date: March 15, 2018
    Inventors: John Wozney, Howard Seeherman, Christopher Todd Brown
  • Designer osteogenic proteins
    Patent number: 9856305
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: January 2, 2018
    Assignee: WYETH LLC
    Inventors: John Wozney, Howard Seeherman, Christopher Todd Brown
  • PROTEIN DELIVERY WITH POROUS METALLIC STRUCTURE
    Publication number: 20170354504
    Abstract: Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.
    Type: Application
    Filed: June 12, 2017
    Publication date: December 14, 2017
    Inventors: Jeffrey WELCH, Eric Vanderploeg, Christopher Wilson, John Wozney
  • COMPOSITE MATRICES DESIGNED FOR ENHANCED BONE REPAIR
    Publication number: 20170319750
    Abstract: Osteoconductive synthetic bone grafts are provided in which porous ceramic granules are embedded in a biocompatible matrix material. The grafts, which may also include one or more of a coating, a reinforcing bio-absorbable mesh, and an osteoinductive protein or peptide, are generally porous and may incorporate fenestrations.
    Type: Application
    Filed: May 8, 2017
    Publication date: November 9, 2017
    Inventors: Orly Grinberg, Nadav Orr, Howard Seeherman, Oded Shoseyov, Eric Vanderploeg, Christopher Wilson, John Wozney
  • MATRIX FOR ENHANCED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR
    Publication number: 20170209623
    Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Application
    Filed: October 31, 2016
    Publication date: July 27, 2017
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
  • Systems and Methods for Improved Delivery of Osteoinductive Molecules in Bone Repair
    Publication number: 20160184390
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Application
    Filed: December 29, 2015
    Publication date: June 30, 2016
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher C. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • OSTEOGENIC PROTEINS
    Publication number: 20160052984
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: April 6, 2015
    Publication date: February 25, 2016
    Inventors: John WOZNEY, Howard Seeherman, Christopher Todd Brown
  • Designer osteogenic proteins
    Patent number: 8952131
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: February 10, 2015
    Assignee: Wyeth LLC
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Wozney, Howard Seeherman, Z. Sean Juo, Valerie P. Calabro, Christopher Todd Brown
  • DESIGNER OSTEOGENIC PROTEINS
    Publication number: 20120046227
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: WYETH LLC
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Wozney, Howard Seeherman, Z. Sean Juo, Valerie Calabro, Christopher Todd Brown
  • Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
    Patent number: 7608580
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: October 27, 2009
    Assignees: Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
  • INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS
    Publication number: 20070134342
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Application
    Filed: January 18, 2007
    Publication date: June 14, 2007
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
  • Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
    Patent number: 7189392
    Abstract: An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 13, 2007
    Assignees: Genetics Institute, LLC, Fidia Advanced Biopolymers S.R.L.
    Inventors: Hyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney