Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an ?-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4).

Abstract: Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits for carrying out the subject methods are also provided.

Abstract: An exemplary embodiment providing for one or more improvements includes an advertising auction system that has an administration server for managing available advertising space and advertising auctions. One or more publishers list their available advertising space at the administration server and one or advertisers bid on the available advertising space wherein a highest bidder at a close of an auction will have their advertisement placed at the available advertising space made available by the one or more publishers for a period of time.

Abstract: An exemplary embodiment providing for one or more improvements includes an advertising auction system that has an administration server for managing available advertising space and advertising auctions. One or more publishers list their available advertising space at the administration server and one or advertisers bid on the available advertising space wherein a highest bidder at a close of an auction will have their advertisement placed at the available advertising space made available by the one or more publishers for a period of time.

Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an ?-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4).

Abstract: An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., ?-GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.

Abstract: A method of playing a word construction game wherein one character, letter or stroke is added at a time to a defined space appearing on a paper surface, computer interface, mobile communication device screen, personal digital assistant or a non-paper erasable surface displaying discrete blank spaces. Each player aims to add at least one character, letter or stroke in turn anywhere within the array of previously played content and available blank spaces that continues the formation of a valid word without completing it. The completion of a valid word subjects the active player to challenge and a penalty in scoring. Absent losing a challenge, players receive points for each character, letter or stroke added without successful challenge during a round of play. Valid words must read without skipping any characters, letters or strokes or any blank spaces, be a predetermined minimum length, and meet other conditions as prescribed by preset rules.

Abstract: The present invention provides a high efficiency method of deriving pluripotent mammalian stem cells from single, dissociated blastomeres harvested from preimplantation embryos.

Abstract: Embodiments of a device for providing an interface to the Internet using standard analog telephones and household telephone lines are described. An interactive console incorporates a display panel, analog telephone adapter, broadband router, and wireless Internet protocol interface in an integrated housing. The interactive console connects to a standard analog telephone, and interfaces the telephone to an Internet protocol network. A server computer coupled to the Internet protocol network provides Internet and digital network services to users of the console, as well as interconnection to other server computers and resources on the Internet. The interactive console and server system thus provide an interface for existing telephone users to gain Internet intelligence and interact with the greater Internet community.

Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

Abstract: Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue; a method for identifying an infective agent able to infect pulmonary cells; a method for the production of a virus able to infect pulmonary cells and method for identifying a compound interfering with infection of a cell by an infective agent.

Abstract: An exemplary embodiment includes an advertising auction system that has an administration server for managing available advertising space and advertising auctions. One or more publishers can list available advertising space at the administration server and one or more advertisers can bid on the available advertising space. The winner can have an advertisement placed at the available advertising space made available by the one or more publishers for a period of time.

Abstract: A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue.

Abstract: A bi-directional damper valve is provided for connecting to a hydraulic line, to regulate fluid flow therethrough. The damper valve includes a main valve body having a flow passage formed therethrough, and the flow passage widens at central portion of the valve body to form a central chamber, which has valve seats formed at opposite ends thereof. The main valve body also has two bypass channels formed therein, which branch off the central chamber near the valve seats, and which selectively communicate with the flow passage. The damper valve also includes two poppets, oriented facing in opposite directions in the central chamber. Each of the poppets has a hollow bore formed therethrough, to always allow fluid flow through the damper valve at a first (minimal) rate. The damper valve also includes a spring extending between the poppets, and normally biasing them against the valve seats.

Abstract: A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue.

Abstract: A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue.

Abstract: A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF). Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue.

Abstract: The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an effective pre-conditioning amount of human fetal cord blood mononuclear cells; maintaining the rodent for from about 5 to 10 days; and injecting the rodent with an effective engrafting amount of primary human leukemia cells. An in vivo and in vitro model of human leukemia are also provided.

Abstract: A system and method for scheduling packet output according to a quality of service (QoS) action specification. A system is provided with a calendar queue with a plurality of bandwidth timeslots, wherein the bandwidth timeslots are organized into groups. A look-up logic circuitry inspects a group of bandwidth timeslots substantially simultaneously and determines from the group a first unoccupied bandwidth timeslot in which a current packet can be scheduled. The look-up logic circuitry also determines a first occupied bandwidth timeslot that contains a next packet to be transmitted.

Abstract: Methods included herein describe the treatment of a tumor by administering dendritic cells either directly into the same or into its surrounding tissue. Further methods describe the induction of immune cell infiltration into tumors and the treatment of tumors with unprimed dendritic cells by administering dendritic cells in a similar fashion. The methods of the present invention are particularly advantageous in the treatment of brain tumors and other solid tumors disposed throughout the body of a mammal that are difficult or impossible to treat by conventional surgical means. Dendritic cell-based compositions effective in the treatment of such tumors are also described.