Patents by Inventor Johnny Yasuo Nagasawa

Johnny Yasuo Nagasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolone analogs and methods related thereto
    Patent number: 8853234
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: October 7, 2014
    Assignee: Senhwa Biosciences, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • OXINDOLE COMPOUNDS
    Publication number: 20120190669
    Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
    Type: Application
    Filed: January 20, 2012
    Publication date: July 26, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Mustapha Haddach, Johnny Yasuo Nagasawa
  • Oxindole compounds
    Patent number: 8124649
    Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 28, 2012
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Mustapha Haddach, Johnny Yasuo Nagasawa
  • QUINOLONE ANALOGS AND METHODS RELATED THERETO
    Publication number: 20110218184
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 8, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Johnny Yasuo NAGASAWA, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • Inhibitors of Akt activity
    Patent number: 8003643
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: August 23, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D. P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa
  • Quinolone analogs and methods related thereto
    Patent number: 7928100
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 19, 2011
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • HYDRAZIDE COMPOUNDS AND USES THEREOF
    Publication number: 20110065687
    Abstract: This application relates to certain novel polycyclic compounds that interact with quadruplex-forming regions of polynucleotides and thereby inhibit translation of genetic information into polypeptides. These compounds can thus provide anticancer and antibacterial and antiviral effects. The invention includes novel compounds and pharmaceutical compositions, and methods of using them to treat cancer and other conditions.
    Type: Application
    Filed: April 17, 2008
    Publication date: March 17, 2011
    Inventors: Michael Schwaebe, Johnny Yasuo Nagasawa, Mustapha Haddach
  • QUINOLONE ANALOGS DERIVATIZED WITH SULFONIC ACID, SULFONATE OR SULFONAMIDE
    Publication number: 20100305136
    Abstract: The present invention provides quinolone analogs derivatized with a sulfonic acid, sulfonate or sulfonamide group, which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs quinolone analogs derivatized with a sulfonic acid, sulfonate or sulfonamide group, and methods of using the same.
    Type: Application
    Filed: June 8, 2007
    Publication date: December 2, 2010
    Inventor: Johnny Yasuo Nagasawa
  • OXINDOLE COMPOUNDS
    Publication number: 20100041635
    Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
    Type: Application
    Filed: June 30, 2009
    Publication date: February 18, 2010
    Inventors: Mustapha HADDACH, Johnny Yasuo NAGASAWA
  • Inhibitors of Akt activity
    Patent number: 7655649
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: February 2, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D. P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa
  • QUINOLONE ANALOGS AND METHODS RELATED THERETO
    Publication number: 20090093455
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 9, 2009
    Inventors: Johnny Yasuo NAGASAWA, Fabrice PIERRE, Mustapha HADDACH, Michael SCHWAEBE, Levan DARJANIA, Jeffrey P. WHITTEN
  • Inhibitors of Akt Activity
    Publication number: 20080280889
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration (if the compounds of the invention.
    Type: Application
    Filed: April 5, 2005
    Publication date: November 13, 2008
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D.P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa
  • Modulators of the glucocorticoid receptor and method
    Patent number: 7235662
    Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure where R1–R9, X, Y and Z are defined herein.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: June 26, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sara Sabine Hadida-Ruah, Xiaohui He, Johnny Yasuo Nagasawa
  • Modulators of the glucocorticoid receptor and method
    Publication number: 20040266758
    Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure 1
    Type: Application
    Filed: June 10, 2004
    Publication date: December 30, 2004
    Inventors: Sara Sabine Hadida-Ruah, Xiaohui He, Johnny Yasuo Nagasawa