Patents by Inventor Jon C. Mitchell
Jon C. Mitchell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10662434Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: GrantFiled: November 12, 2015Date of Patent: May 26, 2020Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey C. Miller, Fyodor Urnov
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Publication number: 20160130314Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: ApplicationFiled: November 12, 2015Publication date: May 12, 2016Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey C. Miller, Fyodor Urnov
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Patent number: 9187758Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: GrantFiled: December 13, 2007Date of Patent: November 17, 2015Assignees: Sangamo BioSciences, Inc., Dow AgroSciences LLCInventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
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Patent number: 8921112Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: GrantFiled: October 1, 2008Date of Patent: December 30, 2014Assignees: Dow AgroSciences LLC, Sangamo BioSciences, Inc.Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
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Patent number: 7795395Abstract: The invention relates to isolated genes encoding Xenorhabdus toxin complex (TC) proteins, and transgenic plants and host cells expressing Xenorhabdus toxin complex (TC) proteins and having resistance to insects.Type: GrantFiled: September 3, 2009Date of Patent: September 14, 2010Assignee: Dow AgroSciences LLCInventors: Patricia C. Apel-Birkhold, Timothy D. Hey, Joel J. Sheets, Thomas Meade, Ze-Sheng Li, Justin M. Lira, Sean M. Russell, Robin L. Thompson, Jon C. Mitchell, Kristin Fencil
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Patent number: 7709623Abstract: The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.Type: GrantFiled: April 13, 2009Date of Patent: May 4, 2010Assignee: Dow AgroSciences LLCInventors: Scott B. Bintrim, Jon C. Mitchell, Ignacio M. Larrinua, Patricia C. Apel-Birkhold, Susan B. Green, Barry W. Schafer, Scott A. Bevan, Scott A. Young, Lining Guo
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Patent number: 7585944Abstract: The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus bovienii strain ILM104.Type: GrantFiled: September 18, 2007Date of Patent: September 8, 2009Assignee: Dow Agrosciences LLCInventors: Patricia C. Apel-Birkhold, Timothy D. Hey, Joel J. Sheets, Thomas Meade, Ze-Sheng Li, Justin M. Lira, Sean M. Russell, Robin L. Thompson, Jon C. Mitchell, Kristin Fencil
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Publication number: 20090221501Abstract: The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin.Type: ApplicationFiled: February 16, 2009Publication date: September 3, 2009Applicant: Dow AgroSciences LLCInventors: Timothy D. Hey, Amanda D. Schleper, Scott A. Bevan, Scott B. Bintrim, Jon C. Mitchell, Ze Sheng Li, Weiting Ni, Baolong Zhu, Donald J. Merlo, Patricia C. Apel-Birkhold, Thomas Meade
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Publication number: 20090203612Abstract: The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.Type: ApplicationFiled: April 13, 2009Publication date: August 13, 2009Applicant: Dow Agrosciences LLCInventors: Scott B. Bintrim, Jon C. Mitchell, Ignacio M. Larrinua, Patricia C. Apel-Birkhold, Susan B. Green, Barry W. Schafer, Scott A. Bevan, Scott A. Young, Lining Guo
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Publication number: 20090111188Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: ApplicationFiled: October 1, 2008Publication date: April 30, 2009Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
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Patent number: 7517956Abstract: The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.Type: GrantFiled: March 14, 2006Date of Patent: April 14, 2009Assignee: Dow Agrosciences LLCInventors: Scott B. Bintrim, Jon C. Mitchell, Ignacio M. Larrinua, Patricia C. Apel-Birkhold, Susan B. Green, Barry W. Schafer, Scott A. Bevan, Scott A. Young, Lining Guo
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Patent number: 7491698Abstract: The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin.Type: GrantFiled: January 7, 2004Date of Patent: February 17, 2009Assignee: Dow AgroSciences LLCInventors: Timothy D. Hey, Amanda D. Schleper, Scott A. Bevan, Scott B. Bintrim, Jon C. Mitchell, Ze Sheng Li, Weiting Ni, Baolong Zhu, Donald J. Merlo, Patricia C. Apel-Birkhold, Thomas Meade
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Publication number: 20090042254Abstract: Improved expression of active antibody fragments (Fabs) is achieved by truncating a heavy chain constant region. Truncation of the CH1 domain of a Fab fragment can increase yield of soluble active antibody fragment in Pseudomonas fluorescens. Another embodiment of the invention includes secretion of the light chain and a fragment of the heavy chain with various C-termini (e.g., VH-CH1 truncated to different lengths). The truncated CH1 region can be used as a scaffold to create other Fabs. Also included is truncation of the kappa light chain and/or lambda light chain domains of a Fab fragment. The invention also includes expression of Fab fragments fused to other peptides or molecules (e.g., toxins, proteins, peptides, enzymes, etc.).Type: ApplicationFiled: June 6, 2008Publication date: February 12, 2009Applicant: DOW GLOBAL TECHNOLOGIES INC.Inventors: Diane Retallack, Jon C. Mitchell
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Publication number: 20080182332Abstract: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.Type: ApplicationFiled: December 13, 2007Publication date: July 31, 2008Inventors: Qihua C. Cai, Vipula K. Shukla, Joseph F. Petolino, Lisa W. Baker, Robbi J. Garrison, Ryan C. Blue, Jon C. Mitchell, Nicole L. Arnold, Sarah E. Worden, Jeffrey Miller, Fyodor Urnov
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Patent number: 7071386Abstract: The subject invention relates to novel nucleic acid encoding a Xenorhabdus strain Xwi toxin complex (TC) protein and plants and bacteria transformed therewith.Type: GrantFiled: January 7, 2004Date of Patent: July 4, 2006Assignee: Dow Agrosciences LLCInventors: Scott B. Bintrim, Jon C. Mitchell, Ignacio M. Larrinua, Patricia C. Apel-Birkhold, Susan B. Green, Barry W. Schafer, Scott A. Bevan, Scott A. Young, Lining Guo
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Publication number: 20040208907Abstract: The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin.Type: ApplicationFiled: January 7, 2004Publication date: October 21, 2004Applicant: Dow AgroSciences, LLCInventors: Timothy D. Hey, Amanda D. Schleper, Scott A. Bevan, Scott B. Bintrim, Jon C. Mitchell, Ze Sheng Li, Weiting Ni, Baolong Zhu, Donald J. Merlo, Patricia C. Apel-Birkhold, Thomas Meade
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Publication number: 20040194164Abstract: The subject inventions relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifcally, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. The exochitinase can be used to control insects using methods known in the art.Type: ApplicationFiled: January 7, 2004Publication date: September 30, 2004Applicant: Dow AgroSciences, LLCInventors: Scott B. Bintrim, Jon C. Mitchell, Ignacio M. Larrinua, Patricia C. Apel-Birkhold, Susan B. Green, Barry W. Schafer, Scott A. Bevan, Scott A. Young, Lining Guo