Abstract: A rollator to aid mobility is described. The rollator comprises an A-frame with two pairs of uprights, each pair of uprights connected by at least one respective hinge to allow each pair of uprights to be folded or pivot front-to-back and a seat disposed between the two pairs of uprights, the seat foldable side-to-side. To fold compactly the rollator comprises an X-shaped cross-linkage comprising four linkage members. A method of manufacturing the rollator is also disclosed. The four linkage members may extend from a respective upright to a central hub underneath the seat. The cross-linkage may fold or pivot at the central hub in both front-to back and side-to-side dimensions when the rollator is folded away.

Abstract: A cap for a container, wherein the cap is adapted to be positioned across the mouth of a container, the cap comprising: an upper portion that lies across the mouth of a container; a sealed compartment for storing contents to be added to the container interior, the compartment being located below the upper portion, and defined by a lower membrane and a wall extending between the upper portion and the lower membrane, wherein the lower membrane is rupturable; and a piercer in the sealed compartment that is actuable through the upper portion to pierce the lower membrane, wherein the piercer is configured to form a passage therethrough to open the compartment to the container interior.

Abstract: A cap for a container, wherein the cap is adapted to be positioned across the mouth of a container, the cap comprising: an upper portion that lies across the mouth of a container; a sealed compartment for storing contents to be added to the container interior, the compartment being located below the upper portion, and defined by a lower membrane and a wall extending between the upper portion and the lower membrane, wherein the lower membrane is rupturable; and a piercer in the sealed compartment that is actuable through the upper portion to pierce the lower membrane, wherein the piercer is configured to form a passage therethrough to open the compartment to the container interior.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl, or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2-fluoroalkyl, halogen, NR6R7, optionally substituted heteroaryl, or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

Abstract: A trolley (10), including a trolley frame (12), a plurality of wheels (14,16), (18,20) mounted to the frame (12) for supporting the trolley (10) thereon, and a direction control wheel (22). The direction control wheel (22) is connected to the frame (12) and displaceable relative to the frame (12) between at least three positions, the at least three positions including a ground contact position, a ground clearance position and an obstacle negotiating position. The direction control wheel (22) is provided for controlling the direction of travel of the trolley (10) when in the ground contact position. The direction control wheel (22) is operably movable between the ground contact position and the ground clearance position, and independently movable between the ground contact position and the obstacle negotiating position. Further, the direction control wheel (22) is independently movable between the ground clearance position and the obstacle negotiating position.

Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is C1-6alkyl, C3-6cycloalkyl, —CH2—R6, —CHMe-R7, —CMe2-R7, or optionally substituted aryl; wherein, when A is optionally substituted aryl, said aryl group is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6alkyl, —CF3, C1-4alkoxy, C1fluoroalkoxy, cyano, NR8R9, and pyridyl wherein the pyridyl is optionally substituted by one methyl; R1 is chlorine, fluorine, —CF3, cyano or C1-6alkyl; R2, R3 and R5 independently are hydrogen, fluorine, chlorine, —CF3, cyano or C1-6alkyl, such that at least one of R2, R3 and R5 is other than hydrogen; R4 is hydrogen. These compounds and salts are thought to be P2X7 receptor antagonists. The invention also provides for the treatment of pain, inflammation, rheumatoid arthritis, osteoarthritis, or a neurodegenerative disease.

Abstract: The present invention provides a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: wherein R1 represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylmethyl-, phenyl-X— or heteroaryl, any of which may be optionally substituted; X represents —(CR12R13)n—; n represents 0 to 2; and R7, R8, R9, R10 and R11 independently represent H, halogen, or cyano; or optionally substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-6 cycloalkyl; such that at least two of R7, R8, R9, R10 and R11 represent a group other than H and at least one of R7 and R11 represents a group other than H; and wherein the compound is other than N-[(2,4-dichlorophenyl)methyl]5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxamide. The compounds and salts are thought to modulate P2X7 receptor function and be capable of antagonizing the effects of ATP at the P2X7 receptor.

Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of interfering with the effects of ATP at the P2X7 receptor. The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.

Abstract: A foldable cot (10) includes an upper peripheral frame (16) and first and second supporting leg structures (20). The A foldable cot (10) includes an upper peripheral frame (16) and first and second supporting leg structures (20). The peripheral frame (16) comprises a first U-shaped frame portion (20) and a second U-shaped frame portion (20) wherein the first U-shaped frame portion and the second U-shaped frame portion each have first and second ends (24, 26). The first ends (24) substantially meet at a first junction (28) and the second ends (26) substantially meet at a second junction (30) to thereby define a substantially closed loop peripheral frame. The first and second U-shaped frames (20) are pivotable relative to the first and second junctions (28, 30) to adjust from an erected configuration to a folded configuration.

Abstract: Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclylC1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except for hydrogen may be optionally substituted; R2 and R3 independently represent optionally substituted C1-6alkyl, or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted C3-7cycloalkyl or C3-7cycloalkenyl ring; or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted 5 to 7-membered heterocyclyl ring containing up to 3 heteroatoms selected from N, O, S.

Abstract: Compounds of formula (I) wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6-alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclylC1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except for hydrogen may be optionally substituted; R2 and R3 independently represent optionally substituted C1-6-alkyl, or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted C3-7cycloalkyl or C3-7cycloalkenyl ring; or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted 5 to 7-membered heterocyclyl ring containing up to 3 heteroatoms selected from N, O, S.

Abstract: A roll-off self-powered fuel dispensing platform system which is transportable, deployable, and made operable by a single individual, from a vehicle such as a truck and which includes a roll-off platform assembly, a roller assembly, and a large planar base. A plurality of essential and sensitive components including a fuel vessel, a fuel pumping and metering unit, a pivotally collapsible gravity operated fuel distribution hose support, a fuel distribution hose having a fuel nozzle, and an area lighting apparatus including a pivotally collapsible light standard and a light are mounted on the large planar base. These essential and sensitive components are all confined within a security fence which is mounted on the large planar base around the perimeter thereof. The security fence includes front and side access doors or gates.

Abstract: A door hinge and a method of its use is provided which is suitable for use with glass shower screen doors. The method involves cutting a pair of circular cut-outs at a side edge of the door near the top and bottom of the door respectively. After toughening of the cut-out portions of glass, a hinge in accordance with this invention is mounted in each cut-out portion. The hinges each have a first arm which has a circular door mounting portion of substantially the same diameter as the cut-outs which are located in the cut-outs. The hinges each have two clamping parts, one part is fitted to abut with one face of the door, and the other part is fitted to abut with the other face of the door. Each part is fitted to immediately surround the respective cut-outs. The hinge then has screw holding means which holds the parts together and clamps the door. The second arm of the hinge can be mounted directly to a frame member, such as a jam member or to a further glass panel.

Abstract: A post production offline editing system for storing unedited video takes in a random access memory (which is preferably a set of laser video disk players), displaying selected takes (or individual frames from selected takes), and generating an edit list which defines an edited video program. The system includes a computer programmed with software providing an integrated software environment which enables a user conveniently to log unedited takes into the system, and to generate an edit list suitable for use in a subsequent online editing operation. The system software provides global access to a variety of video post production environments at any point during an offline editing operation. The system software presents menus to the user including icons or mnemonic text in windows which may be conveniently selected by the user using a mouse.