Patents by Inventor Jon H. Come

Jon H. Come has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
    Publication number: 20110135603
    Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: October 15, 2010
    Publication date: June 9, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Tiansheng Wang, Alexander Aronov, Mark Cornebise, Francois Maltais, Mark Ledeboer, Arnaud Le Tiran, Valerie Marone, David Messesrsmith, Kevin Cottrell, Jon H. Come, Gabriel Martinez Botella
  • INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
    Publication number: 20100316605
    Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: June 9, 2010
    Publication date: December 16, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Kevin Michael Cottrell, Alex Aronov, Robert J. Davies, Jon H. Come, David Messersmith
  • INHIBITORS OF C-MET AND USES THEREOF
    Publication number: 20100190774
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Application
    Filed: April 8, 2010
    Publication date: July 29, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David J. Lauffer, Alexander Aronov, Pan Li, David D. Deininger, Kira McGinty, Dean Stamos, Jon H. Come, Michelle Stewart
  • Inhibitors of c-Met and uses thereof
    Patent number: 7728017
    Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: June 1, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David J. Lauffer, Alexander Aronov, Pan Li, David D. Deininger, Kira McGinty, Dean Stamos, Jon H. Come, Michelle Stewart
  • Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
    Patent number: 7605175
    Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: October 20, 2009
    Assignees: GPC Biotech AG, GPC Biotech, Inc.
    Inventors: Frank Becker, Nicholas Bockovich, Jon H. Come, Arthur F. Kluge, Krishna K. Murthi, Chris Oalmann, Siya Ram, Zhongguo Wang
  • Inhibitors of TACE
    Patent number: 7485664
    Abstract: The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: February 3, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Upul Bandarage, Jon H. Come, Emanuele Perola, Govinda Rao Bhisetti, Jeffrey O. Saunders, Tiansheng Wang, Shi-Kai Tian
  • Aminofurazan compounds useful as protein kinase inhibitors
    Patent number: 7157476
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: January 2, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jon H. Come, Jeremy Green, Craig Marhefka, Scott L. Harbeson, Ly Pham
  • Three hybrid assay system
    Patent number: 7135550
    Abstract: The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
    Type: Grant
    Filed: September 3, 2002
    Date of Patent: November 14, 2006
    Assignees: GPC Biotech Inc., GPC Biotech AG
    Inventors: Jon H. Come, Frank Becker, Nikolai A. Kley, Christoph Reichel
  • Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
    Publication number: 20040266854
    Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.
    Type: Application
    Filed: April 7, 2004
    Publication date: December 30, 2004
    Applicants: GPC Biotech, Inc., GPC Biotech AG
    Inventors: Frank Becker, Nicholas Bockovich, Jon H. Come, Arthur Kluge, Krishna K. Murthi, Chris Oalmann, Siya Ram, Zhongguo Wang
  • Inhibitors of TACE
    Publication number: 20040186088
    Abstract: The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 23, 2004
    Inventors: Upul Bandarage, Jon H. Come, Emanuele Perola, Govinda Rao Bhisetti, Jeffrey O. Saundres
  • Three hybrid assay system
    Publication number: 20040043388
    Abstract: The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
    Type: Application
    Filed: September 3, 2002
    Publication date: March 4, 2004
    Inventors: Jon H. Come, Frank Becker, Nikolai A. Kley, Christoph Reichel
  • Three hybrid assay system
    Publication number: 20030165873
    Abstract: The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
    Type: Application
    Filed: March 4, 2002
    Publication date: September 4, 2003
    Inventors: Jon H. Come, Frank Becker, Nikolai Kley
  • Inhibitors of bace
    Publication number: 20030095958
    Abstract: The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.
    Type: Application
    Filed: April 29, 2002
    Publication date: May 22, 2003
    Inventors: Govinda R. Bhisetti, Jeffrey O. Saunders, Mark A. Murcko, Christopher A. Lepre, Shawn D. Britt, Jon H. Come, David D. Deininger, Tianshang Wang