Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

Abstract: A drinking straw is marked to describe a particular type of drink in order to aid users to quickly and accurately identify drink contents. For example, the drinking straw may include text indicating soda, tea, coffee, or other designation of a drink. The drinking straws described herein provide servers, bartenders, and consumers with an easy-to-use tool for projecting what type of drink is in any cup, without having to rely on the drink's look or taste.

Abstract: A direct drive servo-valve wherein rotational motion of a drive motor rotor is converted into linear motion of a spool valve. The drive motor includes a shaft which has affixed to the end thereof a ball which engages the spool valve. The ball is affixed to the shaft by providing a bore internally of the shaft which is disposed eccentrically to the longitudinal axis of the shaft. The ball has a portion thereof ground of so as to provide an integral protrusion which is received within the bore in the end of the shaft. The ball is permanently affixed to the shaft by brazing the protrusion into the bore and a planar surface which surrounds the base of the protrusion to the end of the shaft against which it mates.