Abstract: An endovascular system includes an implant and a delivery system configured to deliver and deploy the implant to a treatment site in a vessel. The implant is radially expandable and configured to be deployed in vessels with diameters ranging from a minimal diameter to a maximal diameter. The delivery system comprises a proximal landing zone indicator comprising a radiopaque marker having a length from a proximal end to a distal end of the radiopaque marker, wherein the proximal end of the radiopaque marker indicates a position of the proximal end of the implant if deployed at a treatment site in a vessel having the minimal diameter, and the distal end of the radiopaque marker indicates a position of the proximal end of the implant if deployed at a treatment site in a vessel having the maximal diameter. A method of delivering an expandable implant to a target site in a patient's vascular system is also disclosed.

Abstract: A balloon catheter includes a tubular body and a balloon circumferentially around a portion of the tubular body. The tubular body includes an outer surface and an inner surface defining a lumen of the tubular body. The balloon comprises a proximal end portion and a distal end portion each being secured to the tubular body, and a distensible portion defining an interior that is in fluid communication with the lumen of the tubular body. The distal end portion of the balloon extends through the outer surface and the inner surface into the lumen of the tubular body, forming a sealing portion circumferentially around the inner surface of the tubular body. A catheter assembly including a balloon catheter and a method of use are also provided.

Abstract: A lithotripsy device includes an elongate body comprising a distal tip portion having an end surface that forms a non-zero angle with a longitudinal axis of the elongate body, a balloon circumferentially around a portion of the elongate body enclosing the end surface of the tip portion defining an interior configured to receive a fluid, and at least one emitter positioned at the end surface of the tip portion of the elongate body. The at least one emitter is configured to generate pressure waves in the fluid propagating through the balloon to disintegrate a calcified lesion. A method of using a lithotripsy device is also provided.

Abstract: A catheter includes an elongate tubular body having a side wall defining a lumen extending between a proximal region and a distal region. The distal region comprises a tip portion capable of deflecting away from the proximal region when the tip portion is unconstrained, thereby forming a curved shape of the tip portion. The side wall of the elongate tubular body axially terminates at the tip portion with a slant cut, thereby forming an end surface of the tip portion defining an opening in a non-circular shape.

Abstract: An occlusion device includes a braided mesh body and at least one pinch member. The braided mesh body comprises plural strands each having a first end portion and a second end portion. The plural strands fold over to bring the second end portions of the plural strands adjacent to the first end portions of the plural strands forming a double-layer of the braided mesh body. In an example occlusion device, at least one of the plural strands is radiopaque, and the at least one pinch member is non-radiopaque.

Abstract: An aspiration catheter includes an elongate tubular body having a proximal end portion and a distal end portion. The elongate tubular body comprises an inner liner and one or more outer layers. The inner liner comprises a first surface defining a lumen of the elongate tubular body and a second surface. The one or more outer layers are disposed over the second surface of the inner liner. In an embodiment, the inner liner has a first thickness at the proximal end portion of the elongate tubular body and a second thickness at the distal end portion of the elongate tubular body smaller than the first thickness. In another embodiment, the inner liner is provided with plural voids between the first surface and the second surface of the inner liner.

Abstract: A method of treating an anatomical cavity of a patient comprises introducing an infusion/aspiration catheter into the patient, such that a plurality of arms of the catheter reside within the anatomical cavity, delivering a fluid into the at least one of a connector, such that fluid exits the at least one fluid port of at least one of the arms, thereby infusing the anatomical cavity with the fluid, and aspirating the fluid into the at least one fluid port of at least one of the arms, such that the fluid exits the connector(s).

Abstract: A method of treating an anatomical cavity of a patient comprises introducing an infusion/aspiration catheter into the patient, such that a plurality of arms of the catheter reside within the anatomical cavity, delivering a fluid into the at least one of a connector, such that fluid exits the at least one fluid port of at least one of the arms, thereby infusing the anatomical cavity with the fluid, and aspirating the fluid into the at least one fluid port of at least one of the arms, such that the fluid exits the connector(s).

Abstract: An infusion/aspiration catheter comprises an elongate catheter body, at least one infusion lumen, and an aspiration lumen extending between a proximal end and a distal end of the catheter body. The aspiration lumen terminates in a distal fluid port at the distal end of the catheter body. The catheter further comprises arms respectively having proximal ends affixed together at the distal end of catheter body. The distal fluid port of the catheter body is between the proximal ends of the arms, the arms have lumens in fluid communication with the infusion lumen(s), and each of the arms has fluid ports in fluid communication with the lumen of the respective arm. The catheter further comprises at least one infusion connector in fluid communication with the infusion lumen(s), and an aspiration connector in fluid communication with the aspiration lumen(s).

Abstract: A method of treating an anatomical cavity of a patient comprises introducing an infusion/aspiration catheter into the patient, such that a plurality of arms of the catheter reside within the anatomical cavity, delivering a fluid into the at least one of a connector, such that fluid exits the at least one fluid port of at least one of the arms, thereby infusing the anatomical cavity with the fluid, and aspirating the fluid into the at least one fluid port of at least one of the arms, such that the fluid exits the connector(s).

Abstract: A tubular implant delivery system includes a delivery catheter having a distal marker and a proximal marker; and a tubular implant loaded in the delivery catheter, the tubular implant having a delivery length when in a collapsed, delivery configuration, and an implanted length shorter than the delivery length when in an expanded, implanted configuration, wherein a distance between the proximal marker and the distal marker on the delivery catheter is based upon a nominal implanted length of the tubular implant.

Abstract: A balloon catheter includes an elongate support member defining first and second openings therein, open proximal and distal ends, and an axial lumen; and a balloon disposed on the elongate support member, the balloon defining a balloon interior through which the support member extends, where the balloon interior has a proximal end region, a middle region, and a distal end region, with the first opening located in the middle region, and the second opening located in the distal end region, such that the support member lumen is in communication with the balloon interior through each of the first and second openings, and such that a pressurized liquid introduced through the open proximal end of the support member will enter the balloon interior through the first opening, and subsequently exit the balloon interior through the second opening, back into the lumen, and out the open distal end of the support member.