Patents by Inventor Jon Thorson
Jon Thorson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220315523Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.Type: ApplicationFiled: June 16, 2022Publication date: October 6, 2022Inventors: Linda P. DWOSKIN, David WATT, Jon THORSON, Mark LEGGAS, Rodney Kip GUY, Jared HAMMILL, Stefan KWIATKOWSKI, Derong DING, Guangrong ZHENG, Peter Anthony CROOKS, Na-Ra LEE
-
Publication number: 20200290948Abstract: The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one N-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one N-phenylalkyl amphetamine derivative to an individual in need thereof.Type: ApplicationFiled: April 14, 2020Publication date: September 17, 2020Inventors: Linda P. DWOSKIN, David WATT, Jon THORSON, Mark LEGGAS, Kip GUY, Jared HAMMILL, Stefan KWIATKOWSKI, Derong DING, Guangrong ZHENG, Peter Anthony CROOKS, Na-Ra LEE
-
Patent number: 9879043Abstract: The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: where X is S or Se, and R1 is an alkyl group.Type: GrantFiled: June 6, 2014Date of Patent: January 30, 2018Assignee: University of Kentucky Research FoundationInventors: Jon Thorson, Tyler Huber, Jianjun Zhang, Shanteri Singh
-
Patent number: 8618269Abstract: The present invention provides glycorandomized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: GrantFiled: April 17, 2012Date of Patent: December 31, 2013Assignee: Wisconsin Alumni Research FoundationInventor: Jon Thorson
-
Publication number: 20120264924Abstract: The present invention provides glycorandomized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: ApplicationFiled: April 17, 2012Publication date: October 18, 2012Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventor: Jon Thorson
-
Patent number: 8198419Abstract: The present invention provides glycorandomaized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: GrantFiled: February 1, 2011Date of Patent: June 12, 2012Assignee: Wisconsin Alumni Research FoundationInventor: Jon Thorson
-
Publication number: 20110124850Abstract: The present invention provides glycorandomized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: ApplicationFiled: February 1, 2011Publication date: May 26, 2011Inventor: Jon Thorson
-
Patent number: 7906460Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.Type: GrantFiled: September 28, 2006Date of Patent: March 15, 2011Assignee: Sloan-Kettering Institute for CancerInventors: Jon Thorson, Dimitar B. Nikilov
-
Publication number: 20080268504Abstract: The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: ApplicationFiled: March 4, 2008Publication date: October 30, 2008Applicant: Wisconsin Alumni Research FoundationInventor: Jon Thorson
-
Patent number: 7348309Abstract: The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: GrantFiled: September 24, 2003Date of Patent: March 25, 2008Assignee: Wisconsin Alumni Research FoundationInventor: Jon Thorson
-
Publication number: 20070178487Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.Type: ApplicationFiled: September 28, 2006Publication date: August 2, 2007Inventors: Jon THORSON, Dimitar Nikilov
-
Patent number: 7122359Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.Type: GrantFiled: December 13, 2001Date of Patent: October 17, 2006Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Jon Thorson, Dimitar B. Nikilov
-
Publication number: 20060041109Abstract: The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation. In a preferred embodiment, the invention provides a library of neoglycoside digitoxin analogs that includes compounds with significantly enhanced cytotoxic potency toward human cancer cells and tumor-specificity, but are less potent Na+/K+-ATPase inhibitors in a human cell line than digitoxin.Type: ApplicationFiled: June 24, 2005Publication date: February 23, 2006Applicant: Wisconsin Alumni Research FoundationInventors: Jon Thorson, Joseph Langenhan
-
Publication number: 20050266523Abstract: The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: ApplicationFiled: April 12, 2005Publication date: December 1, 2005Inventor: Jon Thorson
-
Publication number: 20050239689Abstract: The present invention provides vancomycin analogs and methods related to synthesis of these analogs via chemoenzymatic techniques.Type: ApplicationFiled: May 19, 2005Publication date: October 27, 2005Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventor: Jon Thorson
-
Publication number: 20050208633Abstract: One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred embodiment, the E. coli GalK variant is mutated at one or more amino acids including R28, E34, D37, D174, Y233, C339, Y371, Y371H, M173, M173L and C353. The GalK variants display catalytic activity toward a variety of D or L sugars. Another preferred embodiment provides method of phosphorylating sugars comprising the step of incubating a nucleotide triphosphate (NTP) and a D or L sugar in the presence of a GalK variant such that a sugar phosphate is produced. This sugar phosphate may be further incubated with a nucleotidylyltransferase, such that a NDP-sugar is produced. The NDP-sugar may be further incubated with a biomolecule capable of being glycosylated in the presence of a glycosyltransferase, such that a glycosylated biomolecule is produced.Type: ApplicationFiled: December 6, 2004Publication date: September 22, 2005Inventor: Jon THORSON
-
Publication number: 20040259228Abstract: The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.Type: ApplicationFiled: September 24, 2003Publication date: December 23, 2004Applicant: Wisconsin Alumni Research FoundationInventor: Jon Thorson
-
Publication number: 20030055235Abstract: The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.Type: ApplicationFiled: December 13, 2001Publication date: March 20, 2003Inventors: Jon Thorson, Dimitar B. Nikilov
-
Publication number: 20020187484Abstract: Modified hairpin-forming oligonucleotide to continuously assess nucleotide cleavage by enediynes and other nucleic acid cleavage agents are provided. These oligonucleotide probes, which are also referred to herein as “molecular break lights,” are also useful for continuous assessment of protection of nucleotides from cleavage agents. Probes according to the present invention are useful in assays; improved assays, including multiplexed assays, utilizing such pairs of molecules or moieties; and assay kits that include such pairs. Methods of using the probes are also provided.Type: ApplicationFiled: November 27, 2001Publication date: December 12, 2002Inventors: Jon Thorson, James Prudent