Patents by Inventor Jon W. Hayenga
Jon W. Hayenga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10890595Abstract: A method for pre-positioning a coaxial sample and sheath combination includes calculating a load shape profile including a plurality of layers of substantially equal volume. The calculated load shape profile is incrementally divided into cross-sectional slices at a first set of distance coordinates along a first axis. Each cross-sectional slice transects the plurality of layers. A sample includes a number of objects residing in solution. A sample chamber is loaded with the sample by incrementally dispensing the sample in a plurality of portions along a vertical axis divided into a second set of distance coordinates proportional to the first set of distance coordinates, where each portion has a volume proportional to the cross-sectional slice at the first distance coordinate nearest in value to the second distance coordinate.Type: GrantFiled: October 12, 2017Date of Patent: January 12, 2021Assignee: VISIONGATE, INC.Inventors: Nathaniel Evans, Jon W. Hayenga
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Publication number: 20190113535Abstract: A method for pre-positioning a coaxial sample and sheath combination includes calculating a load shape profile including a plurality of layers of substantially equal volume. The calculated load shape profile is incrementally divided into cross-sectional slices at a first set of distance coordinates along a first axis. Each cross-sectional slice transects the plurality of layers. A sample includes a number of objects residing in solution. A sample chamber is loaded with the sample by incrementally dispensing the sample in a plurality of portions along a vertical axis divided into a second set of distance coordinates proportional to the first set of distance coordinates, where each portion has a volume proportional to the cross-sectional slice at the first distance coordinate nearest in value to the second distance coordinate.Type: ApplicationFiled: October 12, 2017Publication date: April 18, 2019Applicant: VISIONGATE, INC.Inventors: Nathaniel Evans, Jon W. Hayenga
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Patent number: 10028811Abstract: The system includes a reservoir for fluid; a droplet generator for creating a stream of fluid droplets from the fluid wherein the velocity of the stream of droplets is within a range of 20 meters per second to 200 meters per second and the size of the droplets is within a range of 5 microns to 200 microns. A nozzle or nozzles direct the stream of droplets to safely clean a selected tooth or teeth surface area. The specific momentum of effective fluid droplets within the stream of fluid droplets is important in safe and effective cleaning.Type: GrantFiled: January 20, 2005Date of Patent: July 24, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Bart Gottenbos, Jozef Johannes Maria Janssen, Marinus Karel Johannes Jager, Adriaan Willem Cense, Paulus Corenlis Duineveld, Jon W. Hayenga, William E. Bryant, Martijn Jeroen Dekker
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Patent number: 8254023Abstract: An object of interest is illuminated within the field of view of a microscope objective lens located to receive light passing through the object of interest. Light transmitted through the microscope objective lens impinges upon a variable power element. The variable power element is driven with respect to the microscope objective lens to scan through multiple focal planes in the object of interest. Light transmitted from the variable power element is sensed by a sensing element or array.Type: GrantFiled: February 23, 2009Date of Patent: August 28, 2012Assignee: Visiongate, Inc.Inventors: Mathew D. Watson, Jon W. Hayenga
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Patent number: 8090183Abstract: Correcting pattern noise projection images includes acquiring a set of projection images with an optical tomography system including a processor, where each of the set of projection images is acquired at a different angle of view. A threshold is applied to each projection image produce a set of threshold images. Each threshold image may optionally be dilated to produce a set of dilated images that are summed to form an ensemble image. Each of the dilated images is processed to produce a set of binary images. The set of binary images are summed to form an ensemble mask. The ensemble image is divided by the ensemble mask to yield a background pattern noise image. Each projection image is multiplied by a scaling factor and divided by the background pattern noise to produce a quotient image that is filtered to produce a noise corrected projection image.Type: GrantFiled: March 12, 2009Date of Patent: January 3, 2012Assignee: Visiongate, Inc.Inventors: Michael G. Meyer, Jon W. Hayenga, Thomas M. Abbott, David E. Steinhauer
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Patent number: 7867778Abstract: A method for loading a sample for imaging by an optical tomography system. A sample volume including at least one microscopic sample and a viscous fluid is coaxially loaded into a sample delivery tube. The sample volume is impelled through a focus cell into a capillary tube, where the capillary tube has a smaller crossectional area than the sample delivery tube, so that a reduced volume of the at least one microscopic sample and viscous fluid is constrained to a central region within the capillary tube.Type: GrantFiled: February 23, 2007Date of Patent: January 11, 2011Assignee: VisionGate, Inc.Inventors: Jon W. Hayenga, Paul R. Smargiassi
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Publication number: 20100232664Abstract: Correcting pattern noise projection images includes acquiring a set of projection images with an optical tomography system including a processor, where each of the set of projection images is acquired at a different angle of view. A threshold is applied to each projection image produce a set of threshold images. Each threshold image may optionally be dilated to produce a set of dilated images that are summed to form an ensemble image. Each of the dilated images is processed to produce a set of binary images. The set of binary images are summed to form an ensemble mask. The ensemble image is divided by the ensemble mask to yield a background pattern noise image. Each projection image is multiplied by a scaling factor and divided by the background pattern noise to produce a quotient image that is filtered to produce a noise corrected projection image.Type: ApplicationFiled: March 12, 2009Publication date: September 16, 2010Applicant: VISIONGATE, INC.Inventors: Michael G. Meyer, Jon W. Hayenga, Thomas M. Abbott, David E. Steinhauer
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Patent number: 7787112Abstract: An optical projection tomography system is illuminated with a light source. An object-containing tube, a portion of which is located within the region illuminated by the light source, contains an object of interest that has a feature of interest. A detector is located to receive emerging radiation from the object of interest. A lens, including optical field extension elements, is located in the optical path between the object region and the detector, such that light rays from multiple object planes in the object-containing tube simultaneously focus on the detector. The object-containing tube moves relatively to the detector and the lens operate to provide multiple views of the object region for producing an image of the feature of interest at each view.Type: GrantFiled: October 22, 2007Date of Patent: August 31, 2010Assignee: Visiongate, Inc.Inventors: J. Richard Rahn, Jon W. Hayenga
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Publication number: 20100214639Abstract: An object of interest is illuminated within the field of view of a microscope objective lens located to receive light passing through the object of interest. Light transmitted through the microscope objective lens impinges upon a variable power element. The variable power element is driven with respect to the microscope objective lens to scan through multiple focal planes in the object of interest. Light transmitted from the variable power element is sensed by a sensing element or array.Type: ApplicationFiled: February 23, 2009Publication date: August 26, 2010Applicant: VISIONGATE, INC.Inventors: Mathew D. Watson, Jon W. Hayenga
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Patent number: 7648835Abstract: An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR.Type: GrantFiled: August 27, 2008Date of Patent: January 19, 2010Assignee: Micronics, Inc.Inventors: Wayne L. Breidford, Christy A. Lancaster, Jon W. Hayenga, Ronald L. Bardell, Jeffrey F. Tonn, Bernhard H. Weigl
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Patent number: 7569789Abstract: An apparatus and method for sorting particles in a laminar flow microfluidic channel includes a cantilevered coaxial flow injector in a microfluidic device, the cantilevered coaxial flow injector including an elongated cantilever element integrated into the microfluidic device. A coaxial channel runs through the elongated cantilever element, where coaxial channel is sized to pass particles of a predetermined size. An actuator is coupled to the elongated cantilever element, for actuating said elongated cantilever element.Type: GrantFiled: March 16, 2006Date of Patent: August 4, 2009Assignee: VisionGate, Inc.Inventors: Jon W. Hayenga, Alan C. Nelson
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Publication number: 20090103792Abstract: An optical projection tomography system is illuminated with a light source. An object-containing tube, a portion of which is located within the region illuminated by the light source, contains an object of interest that has a feature of interest. A detector is located to receive emerging radiation from the object of interest. A lens, including optical field extension elements, is located in the optical path between the object region and the detector, such that light rays from multiple object planes in the object-containing tube simultaneously focus on the detector. The object-containing tube moves relatively to the detector and the lens operate to provide multiple views of the object region for producing an image of the feature of interest at each view.Type: ApplicationFiled: October 22, 2007Publication date: April 23, 2009Applicant: VISIONGATE, INC.Inventors: J. Richard Rahn, Jon W. Hayenga
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Publication number: 20090081771Abstract: An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR.Type: ApplicationFiled: August 27, 2008Publication date: March 26, 2009Applicant: Micronics, Inc.Inventors: Wayne L. Breidford, Christy A. Lancaster, Jon W. Hayenga, Ronald L. Bardell, Jeffrey F. Tonn, Bernhard H. Weigl
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Publication number: 20090017423Abstract: The system includes a reservoir for fluid; a droplet generator for creating a stream of fluid droplets from the fluid wherein the velocity of the stream of droplets is within a range of 20 meters per second to 200 meters per second and the size of the droplets is within a range of 5 microns to 200 microns. A nozzle or nozzles direct the stream of droplets to safely clean a selected tooth or teeth surface area. The specific momentum of effective fluid droplets within the stream of fluid droplets is important in safe and effective cleaning.Type: ApplicationFiled: January 20, 2005Publication date: January 15, 2009Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Bart Gottenbos, Jozef Johannes Maria Janssen, Marinus Karel Johannes De Jager, Adriaan Willem Cense, Paulus Cornelis Duineveld, Jon W. Hayenga, William E. Bryant, Martijn Jeroen Dekker
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Publication number: 20080205739Abstract: A method for loading a sample for imaging by an optical tomography system. A sample volume including at least one microscopic sample and a viscous fluid is coaxially loaded into a sample delivery tube. The sample volume is impelled through a focus cell into a capillary tube, where the capillary tube has a smaller crossectional area than the sample delivery tube, so that a reduced volume of the at least one microscopic sample and viscous fluid is constrained to a central region within the capillary tube.Type: ApplicationFiled: February 23, 2007Publication date: August 28, 2008Applicant: VISIONGATE, INC.Inventors: Jon W. Hayenga, Paul R. Smargiassi
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Patent number: 7223371Abstract: Described herein is microfluidic device for joining fluids and a related method for doing the same. The device according to the present invention includes a microfluidic junction, an outlet channel, and a plurality of circuit units. A microfluidic junction is an area for converging multiple fluids. An outlet channel is capable of receiving fluid from the microfluidic junction. An outlet channel includes a first end connected with the microfluidic junction, a second end connected with a waste reservoir, and an analysis region positioned between the first end and the second end of the outlet channel. The device also includes a plurality of circuit units.Type: GrantFiled: February 20, 2003Date of Patent: May 29, 2007Assignee: Micronics, Inc.Inventors: Jon W. Hayenga, Bernhard H. Weigl, Ronald L. Bardell, Christopher J. Morris
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Patent number: 6743399Abstract: A microfluidic device which operates without the need for an external power source. The device includes a body structure, at least one microscale channel within the structure, a port for introducing fluid into the channel, and a power source internal to the structure for propelling the fluid through the channel. Various structures are described which embody the invention.Type: GrantFiled: October 6, 2000Date of Patent: June 1, 2004Assignee: Micronics, Inc.Inventors: Bernhard H. Weigl, Clinton L. Williams, Jon W. Hayenga, Ronald L. Bardell, Thomas E. Schulte
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Publication number: 20030175990Abstract: Described herein is microfluidic device for joining fluids and a related method for doing the same. The device according to the present invention includes a microfluidic junction, an outlet channel, and a plurality of circuit units. A microfluidic junction is an area for converging multiple fluids. An outlet channel is capable of receiving fluid from the microfluidic junction. An outlet channel includes a first end connected with the microfluidic junction, a second end connected with a waste reservoir, and an analysis region positioned between the first end and the second end of the outlet channel. The device also includes a plurality of circuit units.Type: ApplicationFiled: February 20, 2003Publication date: September 18, 2003Inventors: Jon W. Hayenga, Bernhard H. Weigl, Ronald L. Bardell, Christopher J. Morris
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Publication number: 20030175980Abstract: A microfluidic device for sorting cells is described. The device includes an input channel, a primary channel, at least two branch channels which connect with the primary channel at a junction, and a sheath injector positioned upstream from the junction. Sample solution, which may contain a population of cells, can be entered into the input channel and hydrodynamically focused into a sample ribbon. The device employs a system for directing fluid flow, and particularly the flow of the sample ribbon, into a branch channel based on a detected cell feature. The system can employ a variety of sorting techniques to change or direct the flow of cells into a particular branch channel.Type: ApplicationFiled: February 20, 2003Publication date: September 18, 2003Inventors: Jon W. Hayenga, Bernhard H. Weigl, Ronald L. Bardell
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Publication number: 20020160518Abstract: A device for promoting sedimentation within microfluidic channels which uses gravity to separate particles from fluid. Particles such as blood cells or beads are separated from a carrier fluid using gravity combined with various devices such as membranes and sonic energy in different embodiments.Type: ApplicationFiled: April 3, 2002Publication date: October 31, 2002Inventors: Jon W. Hayenga, C. Frederick Battrell, Bernhard H. Weigl, Christopher J. Morris, Patrick Saltsman, Gerald L. Klein