Abstract: Taking an individualistic approach to the treatment of chronic pain may soon be the norm of modern-day medicine. The potential to control the type of medication, in addition to external stimulus including, but not limited to electrical, thermal, cold, or ultrasonic, presents itself in a new “toolbox.” The present invention relates to the management of chronic pain through non-opioid, multi modal compounded transdermal applications, whose properties are enhanced externally, by electrical, thermal, or mechanical energy. More specifically, the present invention encapsulates the customization of personal health, in analyzing, applying and contributing to the betterment of patient's well-being, adapting to patient's preference, biological requirements and regulating to various environments based on the individual's specific body part.