Abstract: The invention relates generally to antibodies that bind CD71, activatable antibodies that specifically bind to CD71 and methods of making and using these anti-CD71 antibodies and anti-CD71 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A method comprises receiving an input tensor for convolution with a kernel, dividing the input tensor into one or more tiles with each tile having a size equal to the kernel, flattening the values in the one or more tiles into vectors to generate the flattened input stream.

Abstract: The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of making and using these anti-PDL1 antibodies and anti-PDL1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted B2M gene, or both, for use in treating a B cell malignancy.

Abstract: Provided herein, in some embodiments, are methods and compositions (e.g., cell compositions) for the treatment of cancer, such as CD33+ malignancies.

Abstract: A vehicle includes an instrument panel, a support structure coupled to the instrument panel, and a retainer. The support structure defines a receiver that extends from a lower end to an upper end that is vehicle-upward of the lower end. The portion of the support structure that defines the receiver includes at least one rib that protrudes into the receiver. The retainer includes a barrel portion having a threaded interior surface that defines a hollow and an exterior surface opposite the interior surface and having at least one wing. The retainer also includes a head portion coupled to the barrel portion. The retainer is operably coupled to the support structure, such that the barrel portion is received within the receiver and the at least one wing of the exterior surface is engaged with the at least one rib to maintain the retainer within the receiver.

Abstract: An accessory mounting track includes a forward edge, a rearward edge, an upper surface, a lower surface, a first end region with a first end, a second end region with a second end, and an intermediate region positioned between the first and second end regions. A cross-section of the intermediate region includes an angular portion positioned on either side of a planar portion. The planar portion and the angular portions are delineated by an inflection point at a junction between the planar portion and each of the angled portions. A distance between the upper surface and the lower surface at the angular portions decreases as a distance from a centerline of the intermediate region increases. A distance between the forward edge and the rearward edge at the first and second end regions increases as a distance from the intermediate region increases.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted B2M gene, or both, for use in treating a B cell malignancy.

Abstract: A computational array is implemented in which all operands and results are loaded or output from a single side of the array. The computational array comprises a plurality of cells arranged in n rows and m columns, each configured to produce a processed value based upon a weight value and an activation value. The cells receive weight and activation values via colinear weight and activation transmission channels that each extend across a first side edge of the computational array to provide weight values and activation values to the cells of the array. In addition, result values produced at a top cell of each of the m columns of the array are routed through the array to be output from the same first side edge of the array at a same relative timing at which the result values were produced.

Abstract: Combined therapy for treating multiple myeloma (MM), comprising (a) a population of genetically engineered T cells, which may express a chimeric antigen receptor (CAR) that binds B-cell maturation antigen (BCMA), and (b) an anti-CD38 antibody such as daratumumab or lenalidomide or a derivative thereof.

Abstract: A method for producing T cells expressing a chimeric antigen receptor (CAR-T cells), comprising: (i) culturing CAR-T cells in a medium comprising lenalidomide or a derivative thereof to produce CAR-T cells, and optionally (ii) administering the CAR-T cells to a subject in need of the treatment.

Abstract: Embodiments are directed to a processor having a functional slice architecture. The processor is divided into tiles (or functional units) organized into a plurality of functional slices. The functional slices are configured to perform specific operations within the processor, which includes memory slices for storing operand data and arithmetic logic slices for performing operations on received operand data (e.g., vector processing, matrix manipulation). The processor includes a plurality of functional slices of a module type, each functional slice having a plurality of tiles. The processor further includes a plurality of data transport lanes for transporting data in a direction indicated in a corresponding instruction. The processor also includes a plurality of instruction queues, each instruction queue associated with a corresponding functional slice of the plurality of functional slices, wherein the instructions in the instruction queues comprise a functional slice specific operation code.

Abstract: A display device has a plurality of display panels (21) together forming a single display screen, where each display panel (21) is connected to a display controller (24) which receives display data of a portion of a complete image for display on the display panel (21). The complete image (S1) includes one or more bounded regions (S2, S3, S4, S5) of display data. Each display controller (21) also receives position information relating to a change in lateral position and/or stacking order position of one or more bounded regions that are to be displayed at least partly on that display panel (21). If the display controller (24) determines that it does not have knowledge of display data in the bounded region (S2, S3, S4, S5) to be displayed on the display panel for which the position information was received, it obtains that knowledge from another display controller (24) that has such knowledge.

Abstract: A number of computing devices are controlled from a touchscreen display system using a Touch Intermediator Machine (TIM) receiving information indicating the location of one or more touches on a connected touchscreen panel. The TIM determines whether the pattern of touches received matches one of a pre-programmed set of interface manipulation gestures. If so, the TIM alters the user interface presented on the connected touchscreen display system depending on the gesture detected. If not, the TIM determines the connected computing device associated with the location of the touch received and updated coordinates of the touch received within an area on the touchscreen display system associated with the connected computing device. The TIM transmits information to the relevant connected computing device regarding the touch received. The computing device processes the information to determine the pattern of touches received and responds according to predetermined instructions for user interaction.

Abstract: A method comprises receiving a kernel used to convolve with an input tensor. For a first dimension of the kernel, a square block of values for each single dimensional vector of the kernel that includes all rotations of that single dimensional vector is generated. For each additional dimension of the kernel, group blocks of an immediately preceding dimension into sets of blocks, each set of blocks including blocks of the immediately preceding dimension that are aligned along a vector that is parallel to the axis of the dimension; and generate, for the additional dimension, one or more blocks of values, each block including all rotations of blocks within each of the sets of blocks of the immediately preceding dimension. The block of values corresponding to the last dimension in the additional dimensions of the kernel is output as the expanded kernel.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted ?2M gene, or both, for use in treating a B cell malignancy.

Abstract: Materials and methods for producing genome-edited cells engineered to express a chimeric antigen receptor (CAR) construct on the cell surface, and materials and methods for genome editing to modulate the expression, function, or activity of one or more immuno-oncology related genes in a cell, and materials and methods for treating a patient using the genome-edited engineered cells.

Abstract: A method comprises receiving one or more sizes for each of the dimensions of a kernel that is convolved with an input tensor to generate an output activation, generating a control pattern used to compute output values for the convolution of the input tensor, with the control pattern being a square matrix with each dimension being a size equal to the product of the width and the height of the kernel. The control pattern is generated by generating a value for each position of the control pattern that is based on a location of the position in the control pattern and the one or more sizes of each of the dimensions of the kernel, the value indicating a location from which to access values from a flattened input tensor for the convolution with the kernel.

Abstract: A memory structure having 2m read ports allowing for concurrent access to n data entries can be constructed using three memory structures each having 2? read ports. The three memory structures include two structures providing access to half of the n data entries, and a difference structure providing access to difference data between the halves of the n data entries. Each pair of the 2m ports is connected to a respective port of each of the 2m-1-port data structures, such that each port of the part can access data entries of a first half of the n data entries either by accessing the structure storing that half directly, or by accessing both the difference structure and the structure containing the second half to reconstruct the data entries of the first half, thus allowing for a pair of ports to concurrently access any of the stored data entries in parallel.

Abstract: The system presented here can create a new machine learning model by improving and combining existing machine learning models in a modular way. By combining existing machine learning models, the system can avoid the step of training a new machine model. Further, by combining existing machine models in a modular way, the system can selectively train only a module, i.e. a part, of the new machine learning model. Using the disclosed system, the expensive steps of gathering 8 TB of data and using the data to train the new machine learning model over 16,000 processors for three days can be entirely avoided, or can be reduced by a half, a third, etc. depending on the size of the module requiring training.