Patents by Inventor Jonathan C. Poe

Jonathan C. Poe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20200283727
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 10, 2020
    Applicant: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • Methods of expanding and assessing B cells and using expanded B cells to treat disease
    Patent number: 10611999
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 7, 2020
    Assignee: Duke University
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20180291340
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 11, 2018
    Applicant: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • Methods of expanding and assessing B cells and using expanded B cells to treat disease
    Patent number: 10017739
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 10, 2018
    Assignee: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • CD-20-SPECIFIC ANTIBODIES AND METHODS OF EMPLOYING SAME
    Publication number: 20170088625
    Abstract: The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting B cells or in treating B cell disorders. Also provided are cells, nucleic acids and methods for producing the monoclonal antibodies.
    Type: Application
    Filed: July 13, 2016
    Publication date: March 30, 2017
    Inventors: Thomas F. Tedder, Junji Uchida, Yasuhito Hamaguchi, Jonathan C. Poe
  • CD-20 specific antibodies and methods of employing same
    Patent number: 9416187
    Abstract: The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting B cells or in treating B cell disorders. Also provided are cells, nucleic acids and methods for producing the monoclonal antibodies.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 16, 2016
    Assignee: Duke University
    Inventors: Thomas F. Tedder, Yasuhito Hamaguchi, Jonathan C. Poe
  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20140065118
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: March 12, 2013
    Publication date: March 6, 2014
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • Cd-20 specific antibodies and methods of employing same
    Publication number: 20090136516
    Abstract: The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting B cells or in treating B cell disorders. Also provided are cells, nucleic acids and methods for producing the monoclonal antibodies.
    Type: Application
    Filed: May 7, 2004
    Publication date: May 28, 2009
    Inventors: Thomas F. Tedder, Junji Uchida, Yasuhito Hamaguchi, Jonathan C. Poe