Abstract: Provided herein are compounds such as the compounds having the structure of Formula (XI) and methods of using the same, such as methods of inhibiting kinases.

Abstract: Described are compositions and methods for treating cancer. Some methods comprise the administration of an effective amount of at least one inhibitor of tryptophan 2,3-dioxygenase (TDO) and/or indoleamine 2,3-dioxygenase (IDO), optionally combined with one or more additional anti-cancer agents.

Abstract: A processor includes a decode unit and a byte permute unit. The byte permute unit receives an instruction from the decode unit. The byte permute unit determines whether the instruction corresponds to a shuffle instruction or a shift instruction. For a shuffle instruction, the byte permute unit uses a byte shuffler to perform a shuffle operation indicated by the instruction. For a shift instruction that indicates a shift magnitude, the byte permute unit uses the byte shuffler to byte-level shift a source operand corresponding to the instruction by an integer number of bytes. The byte permute unit also generates a sequence of output bits by bit-shifting the byte-level shifted source operand by a number of bits such that the sum of the number of bits and the integer number of bytes is equal to the shift magnitude.

Abstract: Provided herein are kinase inhibiting compounds and methods of using the same.

Abstract: A microprocessor is provided that has a datapath that is split into upper and lower portions. The microprocessor includes a centralized crossbar switch module having a single data movement module. The data movement module is capable of processing instructions that require operands to be exchanged between upper and lower 64-bit halves of the split architecture. The data movement module can access and process all instructions that require simultaneous access to the entire register contents of the upper and lower portions. The data movement module is configured to execute any one of a number of different instructions to perform data manipulation with respect to one or more “split-operands” (also referred to simply as “operands” herein). The data movement module can exchange data (bytes and/or bits) of operands for the upper and lower 64-bit halves so that bytes and/or bits of operands can be moved or rearranged to other positions during execution of a particular instruction.

Abstract: A processor includes a decode unit and a byte permute unit. The byte permute unit receives an instruction from the decode unit. The byte permute unit determines whether the instruction corresponds to a shuffle instruction or a shift instruction. For a shuffle instruction, the byte permute unit uses a byte shuffler to perform a shuffle operation indicated by the instruction. For a shift instruction that indicates a shift magnitude, the byte permute unit uses the byte shuffler to byte-level shift a source operand corresponding to the instruction by an integer number of bytes. The byte permute unit also generates a sequence of output bits by bit-shifting the byte-level shifted source operand by a number of bits such that the sum of the number of bits and the integer number of bytes is equal to the shift magnitude.

Abstract: A voice communications terminal is provided that includes: a microphone 208 operable to receive an audio stream; and a voice activity detector 220 operable to (a) determine whether the audio stream comprises voice signals and (b) when the audio stream comprises voice signals, at least one of (i) notify a communications server 110 and (ii) provide at least a portion of the audio stream to the communications server 110.