Abstract: A sealant removal composition provided that includes a pyrrolidone solvent, a non-ionic surfactant, and at least one co-solvent. The composition is well suited to removal sulfur-based polymer and silicone-based polymer sealant. A process of removing a sealant from a substrate is provided that includes applying the composition to the sealant. After allowing dwell time for the sealant to swell on the substrate, the sealant is removed.

Abstract: The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: Patient support apparatus is known which include a bolster for supporting a person propped-up in bed to prevent that person from slipping down the bed. It is important, however, to be able to remove and/or deflate the bolster quickly if the patient needs urgent medical attention. The patient support apparatus herein comprises a sheet having a pocket, and an inflated bolster removably received therein, such that in use with the sheet arranged on the bed, the bolster is arrangeable between the person's pelvis and knees, wherein the inflated bolster includes an outer relatively low-friction sleeve for aiding the insertion and removal of the bolster into and out of the pocket, and wherein the bolster comprises a dump valve at one end thereof for rapid deflation of the bolster if necessary, the low-friction sleeve comprising a handle at one end thereof to aid removal of the bolster from the pocket.

Abstract: Solutions to the problems of scuffing and chipping of the paint films in high traffic areas and in tight spaces, such as dressing rooms in department stores, where multiple scrapings of the wall paints are created by consumers, clothes hangers, shoes, etc., and hallways and conference rooms in office and other commercial buildings are disclosed. Wax seeded latex polymers admixed with an added wax in architectural compositions and optionally with polyurethane resin are utilized to create paint films that are resistant to scuffing and chipping.

Abstract: There is provided a new and improved synthetic route for the synthesis of the compound 1-{2-[(1R)-1-aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (Formula (I)) that is readily scalable for commercial production. Also provided are important intermediate compounds that are formed in the new and improved synthetic route for the synthesis of the compound of formula (I).

Abstract: The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group of formula (I): wherein Q is selected from O or S, R1 is an imidazolyl group, wherein the imidazolyl group is unsubstituted or substituted with one or more monovalent substituents, and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: Computer-implemented methods and systems for selecting components to be used in an aircraft system including: a reliability evaluation function, to produce a reliability score, and a complexity evaluation function, to produce a complexity score, are provided; and a multi-objective optimisation function is performed to determine at least one set of candidate components for the aircraft system that satisfy one or more conditions. The multi-objective optimisation function includes selecting a new set of candidate components, performing at least one of the reliability evaluation function and the complexity evaluation function, and evaluating at least one of the reliability score and the complexity score according to the conditions. The new set of candidate components are stored in associated with an indication of the outcome of the evaluation. An aircraft comprising a set of components that have been selected from one or more of the stored sets of components is also provided.

Abstract: A component life prediction system configured to predict the remaining life of a consumable component installed on an aircraft. The system includes a processor configured to: receive wear information indicative of a current wear state of the component; receive schedule information indicative of a future flight schedule for the aircraft; and determine the remaining life of the component based on the received wear information and the received schedule information.

Abstract: A test apparatus and method for testing a trained classifier configured to control an aircraft system. Scenario data includes operating inputs representing an operational state of an aircraft and classifier outputs for controlling the aircraft system, is obtained. Model data representing a model of the at aircraft system is obtained. Error categorisation data for each aircraft operating scenario is generated based on respective classifier outputs applied to the model.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: A music production system comprises: a computer interface comprising at least one input for receiving an external request for a piece of music and at least one output for transmitting a response to the external request which comprises or indicates a piece of music incorporating first music data; a first music production component configured to process second music data according to at least a first input setting so as to generate the first music data; a second music production component configured to receive via the computer interface an internal request, and provide the second music data based on at least a second input setting denoted by the internal request; and a controller configured to determine in response to the external request the first and second input settings, and instigate the internal request via the computer interface.

Abstract: A component life prediction system configured to predict the remaining life of a consumable component installed on an aircraft. The system includes a processor configured to: receive wear information indicative of a current wear state of the component; receive schedule information indicative of a future flight schedule for the aircraft; and determine the remaining life of the component based on the received wear information and the received schedule information.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: An audio system and method for modifying an audio playback including configuring an audio playback device, the audio playback device comprising a plurality of far-field audio inputs; generating the audio playback via the audio playback device; receiving, via at least one far-field audio input of the plurality of far-field audio inputs, a content-agnostic audio input from a first position within an environment; and, modifying the audio playback in response to the content-agnostic audio input.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: An aircraft is disclosed having a wing, the wing having a fixed wing with a wing tip device moveably mounted about a hinge at the tip thereof. The wing tip device is operable between a flight configuration, and a load alleviating configuration for load alleviation during flight. The aircraft includes a restraining assembly operable between a restraining mode in which the wing tip device is held in the flight configuration using a restraining force such as by a brake, and a releasing mode in which the restraining force on the wing tip device is released, such that the wing tip device may adopt the load alleviating configuration.

Abstract: An aircraft is disclosed having a wing, the wing having a fixed wing with a wing tip device moveably mounted about a hinge at the tip thereof. The wing tip device is operable between a flight configuration, and a load alleviating configuration for load alleviation during flight. The aircraft includes a restraining assembly operable between a restraining mode in which the wing tip device is held in the flight configuration using a restraining force such as by a brake, and a releasing mode in which the restraining force on the wing tip device is released, such that the wing tip device may adopt the load alleviating configuration.

Abstract: An audio system and method for modifying an audio playback including configuring an audio playback device, the audio playback device comprising a plurality of far-field audio inputs; generating the audio playback via the audio playback device; receiving, via at least one far-field audio input of the plurality of far-field audio inputs, a content-agnostic audio input from a first position within an environment; and, modifying the audio playback in response to the content-agnostic audio input.