Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: The present invention relates to a sole (100; 200) for a shoe (300), in particular for a cycling shoe (300), comprising: (a.) a three-dimensionally shaped rim (110); and (b.) a plurality of first reinforcing struts (121-127; 221-222), wherein (c.) at least two (122-125; 221-222) of the plurality of first reinforcing struts (121-127; 221-222) extend from a heel region (112) of the rim (110) of the sole (100; 200) to a toe region (115) of the rim (110) of the sole (100; 200), and wherein (d.) the rim (110) of the sole (100; 200) and the plurality of first reinforcing struts (121-127; 221-222) are integrally manufactured as a single piece in an additive manufacturing process.

Abstract: The present invention relates to a sole (100; 200) for a shoe (300), in particular for a cycling shoe (300), comprising: (a.) a three-dimensionally shaped rim (110); and (b.) a plurality of first reinforcing struts (121-127; 221-222), wherein (c.) at least two (122-125; 221-222) of the plurality of first reinforcing struts (121-127; 221-222) extend from a heel region (112) of the rim (110) of the sole (100; 200) to a toe region (115) of the rim (110) of the sole (100; 200), and wherein (d.) the rim (110) of the sole (100; 200) and the plurality of first reinforcing struts (121-127; 221-222) are integrally manufactured as a single piece in an additive manufacturing process.

Abstract: The present invention relates to the use of RAR?2 and/or an agonist thereof in the preparation of a medicament to cause neurite development, neurite growth and/or neurite regeneration.

Abstract: Provided is a method of producing neurite outgrowth and/or development using RAR?2 and/or an agonist thereof.

Abstract: The invention relates to a method of treating a condition in a subject comprising administering an effective amount of an agent to said subject wherein said agent modulates one or more components of the retinoid signaling pathway.