Patents by Inventor Jonathan D. Brodie

Jonathan D. Brodie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TREATING TOURETTE'S DISORDER WITH GABA-AMINOTRANSFERASE INACTIVATORS
    Publication number: 20160151316
    Abstract: The present invention is a method of treating Tourette's Disorder (TD) using GABA ergic drugs that elevate the amount of stored presynaptic GABA and do not significantly increase GABA tone (a continuous background level of GABA signaling) in the brain. The administration of vigabatrin and/or (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid hydrochloride salt is expressly contemplated.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Inventors: Steven MILLER, Jonathan D. BRODIE, Stephen DEWEY
  • Method of treating Tourette'S disorder with GABA-aminotransferase inactivators
    Patent number: 9254274
    Abstract: The present invention is a method of treating Tourette's Disorder (TD) using GABA ergic drugs that elevate the amount of stored presynaptic GABA and do not significantly increase GABA tone (a continuous background level of GABA signaling) in the brain. The administration of vigabatrin and/or (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid hydrochloride salt is expressly contemplated.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 9, 2016
    Assignees: Catalyst Pharmaceutical Partners, Inc., New York University, Feinstein Institute for Medical Research
    Inventors: Steven Miller, Jonathan D. Brodie, Stephen Dewey
  • METHOD OF TREATING TOURETTE'S DISORDER WITH GABA-AMINOTRANSFERASE INACTIVATORS
    Publication number: 20140336256
    Abstract: The present invention is a method of treating Tourette's Disorder (TD) using GABA ergic drugs that elevate the amount of stored presynaptic GABA and do not significantly increase GABA tone (a continuous background level of GABA signaling) in the brain. The administration of vigabatrin and/or (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid hydrochloride salt is expressly contemplated.
    Type: Application
    Filed: July 25, 2014
    Publication date: November 13, 2014
    Inventors: Steven MILLER, Jonathan D. BRODIE, Stephen DEWEY
  • Prevention of addiction in pain management
    Patent number: 6939876
    Abstract: The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: September 6, 2005
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior using a composition of topiramate
    Patent number: 6906099
    Abstract: The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: June 14, 2005
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior
    Patent number: 6890951
    Abstract: The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: May 10, 2005
    Assignee: Brookhaven Science Associates LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior
    Patent number: 6828349
    Abstract: The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: December 7, 2004
    Assignee: Brookhaven Science Associates
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Prevention of addiction in pain management
    Publication number: 20030134868
    Abstract: The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic with addictive liability and a GABAergic agent, such as gamma vinyl GABA (GVG) or topiramate, which is effective in reducing or eliminating the addictive liability of the analgesic without interfering with its pain relieving properties.
    Type: Application
    Filed: January 2, 2003
    Publication date: July 17, 2003
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby
  • Treatment of addiction and addiction-related behavior
    Patent number: 6593367
    Abstract: The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to a combination of abused drugs. The method includes administering to the mammal an effective amount of gamma vinylGABA (GVG) or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of the combination of abused drugs.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: July 15, 2003
    Assignee: Brookhaven Science Associates
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior
    Patent number: 6541520
    Abstract: The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: April 1, 2003
    Assignee: Brookhaven Science Associates
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Prevention of addiction in pain management
    Publication number: 20030004176
    Abstract: The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic.
    Type: Application
    Filed: April 18, 2002
    Publication date: January 2, 2003
    Applicant: Brookhaven Science Associates LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby
  • Prevention of addiction in pain management
    Publication number: 20020187996
    Abstract: The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic.
    Type: Application
    Filed: May 14, 2001
    Publication date: December 12, 2002
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby
  • Novel treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
    Publication number: 20020169103
    Abstract: The present invention relates to the use of gamma vinyl-GABA (GVG) and other GABAergic agents to treat obsessive-compulsive disorder (OCD) and OCD-related disorders, and to reduce or eliminate behaviors associated with obsessive-compulsive disorder (OCD) and OCD-related disorders.
    Type: Application
    Filed: June 20, 2002
    Publication date: November 14, 2002
    Applicant: Brookhaven Science Associates LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby
  • Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
    Patent number: 6462084
    Abstract: The present invention relates to the use of gamma vinyl-GABA (GVG) to treat obsessive-compulsive disorder (OCD) and OCD-related disorders, and to reduce or eliminate behaviors associated with obsessive-compulsive disorder (OCD) and OCD-related disorders.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: October 8, 2002
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of PCP addiction and PCP addiction-related behavior
    Patent number: 6395783
    Abstract: The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to phencyclidine (PCP). The method includes administering to the mammal an effective amount of gamma vinylGABA (GVG) or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of PCP.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: May 28, 2002
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior
    Publication number: 20020042446
    Abstract: The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.
    Type: Application
    Filed: August 20, 2001
    Publication date: April 11, 2002
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby,
  • Treatment of addiction and addiction-related behavior
    Publication number: 20020037925
    Abstract: The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.
    Type: Application
    Filed: February 2, 2001
    Publication date: March 28, 2002
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby
  • Treatment of addiction to ethanol and addictive-related behavior
    Patent number: 6323239
    Abstract: The present invention provides a highly efficient method for treating alcohol addiction and for changing addiction-related behavior of a mammal suffering from alcohol addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increase central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of alcohol.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: November 27, 2001
    Assignee: Brookhaven Science Associates
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.
  • Treatment of addiction and addiction-related behavior
    Patent number: 6057368
    Abstract: The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a primate suffering from substance addiction. The method includes administering to a primate an effective amount of a pharmaceutical composition including gamma vinylGABA. The present invention also provides a method of treatment of nicotine addiction by treating a patient with an effective amount of a composition including gamma vinylGABA.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Brookhaven Science Associates LLC
    Inventors: Stephen L. Dewey, Jonathan D. Brodie, Charles R. Ashby, Jr.