Abstract: Systems and methods are disclosed for providing ongoing monitoring and updating of blood volume status, where the system or method can include guidance in the form of recommendations for treatment actions or alerts about altered patient status.

Abstract: Systems and methods are provided for analyzing blood of a living being, and for presenting guidance for medical treatment.

Abstract: Systems and methods are disclosed for providing ongoing monitoring and updating of blood volume status, where the system or method can include guidance in the form of recommendations for treatment actions or alerts about altered patient status.

Abstract: Systems and methods are provided for measuring blood volume of a living being using fluorescent dye. The present invention greatly simplifies the performance of a blood volume measurement by utilizing a novel fluorescent tracer. An injection and sampling kit for the performance of an indicator dilution measurement, comprising a) a labelled fluorescent injectate, and b) a plurality of collection cassettes, and a calibration kit comprising a plurality of calibrated standard cassettes of identical conformation to the cassettes in b), corresponding to known dilutions of the injectate (a).

Abstract: Pharmaceutical compositions and methods are presented for creating a ternary structure involving a fluorescent molecule, an intermediate carrier molecule, and a larger protein or polymer with a binding site receptive to the intermediate molecule or fluorescent/intermediate complex. The resulting ternary system improves the binding stability of the fluorescent dye to the protein, both in-vivo and in-vitro. This improved stability results in a longer half-life in medical use, enabling improved qualitative and quantitative use of the dye.

Abstract: Methods and systems are presented for analyzing the blood of a living being. Equations are presented for volume-aware extension of the concept of Hematocrit. A method for calculating these volume-aware measures and using said measures to evaluate and guide possible treatments is described. A system comprising an automated analyzer and a processor and other components is described which can carry out said calculations. Methods of treatment for volume abnormalities are described which are guided by the volume-aware Hct measures. In one exemplary embodiment, a method of treatment for plasma volume excess using ultrafiltration is described. In another exemplary embodiment, a method of treatment for red cell volume excess using erythrocytapheresis is described.

Abstract: Systems and methods are disclosed for providing ongoing monitoring and updating of blood volume status, where the system or method can include guidance in the form of recommendations for treatment actions or alerts about altered patient status.

Abstract: Systems and methods are provided for measuring blood volume of a living being.

Abstract: Systems and methods are provided for analyzing blood of a living being, and for presenting guidance for medical treatment.

Abstract: A device is presented for storing, transporting, measuring, and collecting blood, having the properties of a precisely determined volume, the ability to be emptied or filled while connected to a continuous source (such as a supply of a drug, or the bloodstream of a patient), and a geometry suitable for the entire device to be placed in the counting chamber of a detector (such as the counting well of a gamma counter).

Abstract: Methods and systems are presented for analyzing the blood of a living being. Equations are presented for volume-aware extension of the concept of Hematocrit. A method for calculating these volume-aware measures and using said measures to evaluate and guide possible treatments is described. A system comprising an automated analyzer and a processor and other components is described which can carry out said calculations. Methods of treatment for volume abnormalities are described which are guided by the volume-aware Hct measures. In one exemplary embodiment, a method of treatment for plasma volume excess using ultrafiltration is described. In another exemplary embodiment, a method of treatment for red cell volume excess using erythrocytapheresis is described.

Abstract: Systems, methods, and computer programs for performing calculations of cost of entities are described. According to one embodiment, a method is described wherein one or more data sources are identified; information is gathered from those data sources, which is then used to calculate an adjusted cost of the entities. According to another embodiment, the information gathered from the data sources relates to dollar costs and other information pertaining to the entities, which is used to statistically model cost-related figures pertaining to the entities.

Abstract: Embodiments of methods for record linkage and comparing attributes are presented herein. Broadly speaking, embodiments of the present invention associate data records using distance measures and weights. More particularly, embodiments of the present invention generate a weight-based comparison of attributes. More specifically, embodiments of the present invention involve deduplication of records in a single database and linkage of records in multiple databases. In some embodiments of the invention, records may be merged into a master database based on the linkage and comparison of attributes. In addition, embodiments of the present invention may calculate a quality measure to be used in comparing attributes and records.

Abstract: Systems, methods, and computer programs for performing calculations of cost of entities are described. According to one embodiment, a method is described wherein one or more data sources are identified; information is gathered from those data sources, which is then used to calculate an adjusted cost of the entities. According to another embodiment, the information gathered from the data sources relates to dollar costs and other information pertaining to the entities, which is used to statistically model cost-related figures pertaining to the entities.

Abstract: The invention involves systems and methods for generating a unique set of analytics that are dependent on a set of user preferences and a database generated from one or more data sources. The analytics relate to entities of interest to consumers such as restaurants, hotels, or other goods and services. The analytics are provided to consumers over a network such as the internet to aid them in determining which entities of interest to patronize or consume.

Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.

Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.

Abstract: Embodiments of methods for record linkage and comparing attributes are presented herein. Broadly speaking, embodiments of the present invention associate data records using distance measures and weights. More particularly, embodiments of the present invention generate a weight-based comparison of attributes. More specifically, embodiments of the present invention involve deduplication of records in a single database and linkage of records in multiple databases. In some embodiments of the invention, records may be merged into a master database based on the linkage and comparison of attributes. In addition, embodiments of the present invention may calculate a quality measure to be used in comparing attributes and records.

Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.

Abstract: An automated blood analyzer that analyzes blood of a living being including one or more sample carriers that hold samples of blood of a living being, each sample having been withdrawn from the living being at a different point in time after the living being was injected with radio-labeled albumin, means for calculating a set of data points representing blood volume of the living being at the one or more points in time after the living being was injected with the radio-labeled albumin based on detected counts of the radio-labeled albumin in the samples of blood, wherein the automated blood analyzer uses the set of data points for further analysis of the blood of the living being, and a quality control module that at least one of calibrates the means for calculating or verifies that the means for calculating operates within predetermined parameters.