Abstract: Compounds that either produced a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies with improved efficacy are provided.

Abstract: A luminaire (1) is provided comprising a luminaire housing (3), a light module(5), and a communication module (7). The light module comprises a light source (15) for emitting light from the luminaire (1) and wherein the light module (5) is accommodated at least partly within the luminaire housing (3). The communication module (7) is configured for wireless transmitting and/or receiving communication signals which are unrelated to the 5 lighting function of the luminaire and/or to the operation of the light module. The communication module (7) is accommodated within the luminaire housing (3).

Abstract: Disclosed herein are various embodiments comprising methods to propose or modify a basal profile of a user, wherein the basal profile is delivered by an automatic drug delivery system operating in manual mode or is administered manually by the user. Suggestions of initial basal profiles or modifications to existing basal profiles may be based on previous glucose control outcomes or previous insulin delivery as recorded by the automatic drug delivery system.

Abstract: The exemplary embodiments provide an automated approach for adjusting the medicament delivery rate to the user when operating in an open loop manner (“open mode”). The approach relies upon an insulin delivery history to the user make adjustments to the medicament delivery rate in the open mode. In particular, the exemplary embodiments may look at the medicament delivery history while the medicament delivery device is operating in a closed loop manner (“closed mode”) to determine how to adjust the open mode medicament delivery rate. It is presumed that in closed mode, the control system of the medicament device has gained knowledge over time about how to control the medicament delivery rate to produce good treatment outcomes for the user. The exemplary embodiments leverage this knowledge to adjust the open mode medicament delivery rates. Medicament bolus deliveries in open mode may also be adjusted in like fashion.

Abstract: MP35N (35% Co, 35% Ni, 20% Cr, 10% Mo) wires (solid and clad) are widely used for leads in cardiac rhythm management (CRM) and neurological electrical stimulation devices. Over the typical lifetime of a CRM device, a lead wire is subjected to stress cycling imposed by the heartbeat and is expected to survive 300 million stress cycles, or more. Premature fatigue fracture of a lead is sometimes caused by surface imperfections in the wire that has been coiled into the lead. The imperfections can result in concentration of stresses at a specific location on the wire surface. A vexing type of imperfection is a tiny surface fissure that is commonly referred to as a chevron. Wire drawing processes that are commonly used to form wires for manufacturing an implantable lead inherently produce a distribution of tiny chevrons on the wire surface.

Abstract: The present disclosure relates to a method of targeting extracellular vesicles employing a molecule comprising a GLA domain and extracellular vesicles obtained or obtainable from a method disclosed herein.

Abstract: The present disclosure relates to a method of targeting stems cells, in particular non-apoptotic stem cells, employing a GLA domain, capable of binding surface exposed phosphatidyl serine.

Abstract: The present disclosure relates to a method of intracellular delivery of a molecule employing a GLA domain to facilitate entry into the cell.

Abstract: A fission based nuclear thermal propulsion rocket engine. An embodiment provides a source of fissionable material such as plutonium in a carrier fluid having neutron moderating constituents, such as hydrogen and/or carbon, therein. In various embodiments, the carrier fluid may be methane, or ethane, or a combination thereof. A neutron source is provided, such as from a neutron beam generator. By way of engine design geometry, various embodiments may provide for intersection of neutrons with the fissionable material injected by way of the carrier fluid, while in a reactor provided in the form of a reaction chamber. Impact of neutrons on fissionable material results in a nuclear fission in sub-critical mass reaction conditions in the reactor, resulting in release of heat energy to the materials within the reactor.

Abstract: A nuclear thermal propulsion rocket engine. A source of fissionable material is provided in a bed of fuel pebbles located in a reactor. A fluid having neutron moderating constituents, such as hydrogen and/or carbon, therein, is provided, which may be in the form of methane, or ethane, or a combination thereof, or may further include various isotopes of hydrogen. An external neutron source is provided using a neutron beam generator. Reactor design geometry provides containment of fissionable material, and for any byproducts of fission reactions, in the reactor during acceleration of the rocket. Impact of neutrons on fissionable material results in a nuclear fission reaction conditions in the reactor, resulting in release of heat energy to fluids provided to the reactor. The reactor is sized and shaped to contain fuel pebbles containing fissionable material, and to confine expandable fluids as they remove heat from fuel pebbles.

Abstract: A nuclear thermal propulsion rocket engine. A source of fissionable material such as plutonium is provided utilizing a carrier fluid having neutron moderating constituents, such as hydrogen and/or carbon, therein. A carrier fluid may be methane, or ethane, or a combination thereof. A neutron source is provided, such as from a neutron beam generator. Reactor design geometry provides containment of fissionable material in the reactor during acceleration. Collisions occur between neutrons and fissionable material injected by way of the carrier fluid. Impact of neutrons on fissionable material results in a nuclear fission in sub-critical mass reaction conditions in the reactor, resulting in release of heat energy to fluids provided to the reactor.