Patents by Inventor Jonathan J. Rosen
Jonathan J. Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090027280Abstract: The invention relates to micro-resonant devices (MRDs) that generate resonance at radio frequencies not present in an animal or human body, or present at low, background levels in the body. These individual, often monolithic devices, can be located in three-dimensional space and tracked anywhere in a target area, e.g., in a human or animal body, or within a cell within a body, using a conventional magnetic resonance imaging (MRI) scanner or other transducers, e.g., radiofrequency transducers. The MRDs generate high sensitivity contrast in conventional clinical MRI scanners, have a diameter of anywhere from a few nanometers to 1000 microns, and can in some embodiments be manufactured using Micro-Electro-Mechanical Systems (MEMS) technology. The devices are optionally coated to isolate them from the environment, and this coating can be a biocompatible coating for medical and biotechnology uses.Type: ApplicationFiled: May 5, 2006Publication date: January 29, 2009Inventors: John V. Frangioni, Jonathan Bernstein, Jonathan J. Rosen, Robert E. Lenkinski
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Patent number: 7169124Abstract: Methods and apparatus are disclosed for treating body tissue whereby a section of tissue is drawn into contact with the open distal end of the first passageway of the apparatus. A tissue treatment fluid is introduced into the second passageway for treating the desired section of tissue retained within the first passageway. Methods and apparatus are also disclosed for positioning a medical device at a desired location within the heart. A portion of the apparatus is retained at a desired location of the heart and a medical device is extended through a passageway of the apparatus for contacting the heart at the desired location.Type: GrantFiled: April 19, 2004Date of Patent: January 30, 2007Assignee: Novt CorpInventors: Thomas D. Weldon, Charles E. Larsen, Jonathan J. Rosen
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Patent number: 7160238Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: December 21, 1999Date of Patent: January 9, 2007Assignee: Best Vascular, Inc.Inventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 7066872Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: April 11, 2003Date of Patent: June 27, 2006Assignee: Best Vascular, Inc.Inventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 6994665Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: April 2, 2004Date of Patent: February 7, 2006Assignee: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Publication number: 20040267192Abstract: Methods and apparatus are disclosed for treating body tissue whereby a section of tissue is drawn into contact with the open distal end of the first passageway of the apparatus. A tissue treatment fluid is introduced into the second passageway for treating the desired section of tissue retained within the first passageway. Methods and apparatus are also disclosed for positioning a medical device at a desired location within the heart. A portion of the apparatus is retained at a desired location of the heart and a medical device is extended through a passageway of the apparatus for contacting the heart at the desired location.Type: ApplicationFiled: April 19, 2004Publication date: December 30, 2004Inventors: Thomas D. Weldon, Charles E. Larsen, Jonathan J. Rosen
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Publication number: 20040192999Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: ApplicationFiled: April 2, 2004Publication date: September 30, 2004Applicant: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 6723069Abstract: Methods and apparatus are disclosed for treating body tissue whereby a section of tissue is drawn into contact with the open distal end of the first passageway of the apparatus. A tissue treatment fluid is introduced into the second passageway for treating the desired section of tissue retained within the first passageway. Methods and apparatus are also disclosed for positioning a medical device at a desired location within the heart. A portion of the apparatus is retained at a desired location of the heart and a medical device is extended through a passageway of the apparatus for contacting the heart at the desired location.Type: GrantFiled: July 5, 2000Date of Patent: April 20, 2004Assignee: Novoste CorporationInventors: Thomas D. Weldon, Charles E. Larsen, Jonathan J. Rosen
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Publication number: 20030229259Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: ApplicationFiled: April 11, 2003Publication date: December 11, 2003Applicant: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 6503185Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: December 21, 1999Date of Patent: January 7, 2003Assignee: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 6458070Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: December 21, 1999Date of Patent: October 1, 2002Assignee: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul
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Patent number: 6306074Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's intraluminal passageways. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: May 4, 1999Date of Patent: October 23, 2001Assignees: Novoste Corporation, Emory UniversityInventors: Ron Waksman, Thomas D. Weldon, Raphael F. Meloul, Richard A. Hillstead, Jonathan J. Rosen, George K. Bonnoitt, Jr., David S. Halpern, Charles E. Larsen, Ian R. Crocker
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Patent number: 6170800Abstract: An automatic fluid control having a first and second tube members and a slidable valve element capable of moving from a sealed closed position to an open position permitting fluid passage therethrough. In a preferred first embodiment, the elastomeric valve element is slidingly received with a passageway in the first tube. The valve element has a flange portion containing a plurality of slits that, when inverted and stretched, permit fluid to pass therethrough, but when closed, are in contact with the inner wall of the first tube and prevents fluid from passing therethrough. The valve element also can have a rigid plug attached within an opening in the top surface to present a preferably non-deformable contact point for a male luer tip, which, when pressed downward on the valve element, breaks a seal between the valve element and the first tube inner wall.Type: GrantFiled: September 14, 1998Date of Patent: January 9, 2001Assignee: Novoste CorporationInventors: Raphael F. Meloul, Jonathan J. Rosen
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Patent number: 6139522Abstract: Methods and apparatus are disclosed for treating body tissue whereby a section of tissue is drawn into contact with the open distal end of the first passageway of the apparatus. A tissue treatment fluid is introduced into the second passageway for treating the desired section of tissue retained within the first passageway. Methods and apparatus are also disclosed for positioning a medical device at a desired location within the heart. A portion of the apparatus is retained at a desired location of the heart and a medical device is extended through a passageway of the apparatus for contacting the heart at the desired location.Type: GrantFiled: September 19, 1995Date of Patent: October 31, 2000Assignee: Novoste CorporationInventors: Thomas D. Weldon, Charles E. Larsen, Jonathan J. Rosen
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Patent number: 5980492Abstract: A blood containment, visualization and tactile confirmation device is provided for use with a vascular entry needle. The device includes a visualization channel and/or a compliant outer wall portion which indicates whether a needle connected to the device has entered a selected blood vessel. The visualization channel is optionally vented to the outside to allow displaced air to escape, but has a gas permeable member to prevent blood from escaping. Alternatively, the visualization channel is substantially sealed such that it is not significantly vented. Preferably, a compliant outer wall portion defining the visualization channel pulses with changes in blood pressure, thereby providing a tactile indication that the needle tip is properly positioned. The device has a guideway with a barrier of elastomeric material which prevents blood from passing therethrough, but which allows passage of an elongated medical instrument such as catheterization apparatus.Type: GrantFiled: January 27, 1998Date of Patent: November 9, 1999Assignee: Merit Medical Systems, Inc.Inventors: Jonathan J. Rosen, Richard A. Hillstead, Thomas D. Weldon, Charles E. Larsen, David O. Williams
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Patent number: 5899882Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's intraluminal passageways. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: April 4, 1996Date of Patent: May 4, 1999Assignees: Novoste Corporation, Emory UniversityInventors: Ron Waksman, Thomas D. Weldon, Raphael F. Meloul, Richard A. Hillstead, Jonathan J. Rosen, George K. Bonnoitt, Jr., David S. Halpern, Charles E. Larsen, Ian R. Crocker
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Patent number: 5820596Abstract: A blood containment, visualization and tactile confirmation device is provided for use with a vascular entry needle. The device includes a visualization channel and/or a compliant outer wall portion which indicates whether a needle connected to the device has entered a selected blood vessel. The visualization channel is vented to the outside to allow displaced air to escape, but has a gas permeable member to prevent blood from escaping. The visualization channel may have one, two, or more stages, with a first stage chamber which indicates initial penetration of a selected blood vessel, and a second stage chamber which fills more slowly and indicates that the needle remains positioned within the blood vessel. A third stage chamber with entrapped air which compresses slightly due to the heartbeat may also be used. Preferably, a compliant outer wall portion pulses with changes in blood pressure, thereby providing a tactile indication that the needle tip is properly positioned.Type: GrantFiled: March 22, 1996Date of Patent: October 13, 1998Assignee: Merit Medical SystemsInventors: Jonathan J. Rosen, Richard A. Hillstead, Thomas D. Weldon, Charles E. Larsen, David O. Williams
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Patent number: 5806551Abstract: An automatic fluid control having a first and second tube members and a slidable valve element capable of moving from a sealed closed position to an open position permitting fluid passage therethrough. In a preferred first embodiment, the elastomeric valve element is slidingly received with a passageway in the first tube. The valve element has a flange portion containing a plurality of slits that, when inverted and stretched, permit fluid to pass therethrough, but when closed, are in contact with the inner wall of the first tube and prevents fluid from passing therethrough. The valve element also can have a rigid plug attached within an opening in the top surface to present a preferably non-deformable contact point for a male luer tip, which, when pressed downward on the valve element, breaks a seal between the valve element and the first tube inner wall.Type: GrantFiled: March 24, 1995Date of Patent: September 15, 1998Assignee: Novoste CorporationInventors: Raphael F. Meloul, Jonathan J. Rosen
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Patent number: 5746414Abstract: A flow control valve is described comprised of first and second rigid members and a resilient single or multi stage valve element disposed between the rigid members. A fluid flow path is defined through the rigid members and through or around the valve element to provide a continuous flow path through the valve. The rigid members are movable relative to each other between a first position and a second position. The valve element is sufficiently compressed by the rigid members when they are in the first position so as to close the flow path through or around the valve element. The valve element is sufficiently relaxed when the rigid members are in the second position to allow fluid flow through the flow path through or around the valve element.Type: GrantFiled: June 21, 1996Date of Patent: May 5, 1998Assignee: Novoste CorporationInventors: Thomas D. Weldon, Charles E. Larsen, Jonathan J. Rosen
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Patent number: 5683345Abstract: Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.Type: GrantFiled: October 27, 1994Date of Patent: November 4, 1997Assignee: Novoste CorporationInventors: Ron Waksman, Thomas D. Weldon, Richard A. Hillstead, Jonathan J. Rosen, Charles E. Larsen, Ian R. Crocker, Raphael F. Meloul