Patents by Inventor Jonathan L. Rolfe

Jonathan L. Rolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8371296
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: February 12, 2013
    Assignee: Geno, LLC
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Patent number: 8221800
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: July 17, 2012
    Assignee: Geno LLC
    Inventors: David H. Fine, Stephen J. MacDonald, David R. Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Patent number: 8066904
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: November 29, 2011
    Assignee: Geno LLC
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Patent number: 7208222
    Abstract: A porous structure having a plurality of bonded sheets each sheet having at least one aperture that partially overlaps an aperture of at least one other sheet. A method of producing a porous structure including stacking a plurality of sheets each sheet having a multiplicity of apertures, and bonding each sheet to its adjoining sheet. An open-pore network structure having a multiplicity of sheets each having a repeatable pattern. At least a portion of each sheet is bonded to the web of an adjacent sheet. The porous area of at least one of the sheets is askew to the porous area of at least another of the sheets. An open-pore structure having a multiplicity of bonded sheets, each sheet having a repeatable pattern defining a multiplicity of perforations, and a plurality of apertures defined by the repeatable pattern, the apertures extending through the perforations of at least two adjacent plates.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: April 24, 2007
    Assignee: Viasys Healthcare Inc.
    Inventors: Jonathan L. Rolfe, Mark P. Amrich, Joseph A. Buturlia, Robert Cairns, Robert Lynch, Michael Gerry
  • Patent number: 7052671
    Abstract: A composition comprising a carrier liquid; a dispersant; and a chemical hydride. The composition can be used in a hydrogen generator to generate hydrogen for use, e.g., as a fuel. A regenerator recovers elemental metal from byproducts of the hydrogen generation process.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: May 30, 2006
    Assignee: Safe Hydrogen, LLC
    Inventors: Andrew W. McClaine, Jonathan L. Rolfe, Christopher A. Larsen, Ravi K. Konduri
  • Patent number: 7040313
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: May 9, 2006
    Assignee: CyTerra Corporation
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Patent number: 7025869
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: April 11, 2006
    Assignee: CyTerra Corporation
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Patent number: 7018418
    Abstract: Textured surface having micro recesses such that the outer surface overhangs the micro recesses. Embodiments of the textured surface include sharp edges for promoting bone deposition and growth within the micro recesses, protrusions of varying depth from the surface that include overhangs, and micro recesses that are at least partially defined by complex ellipsoids.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: March 28, 2006
    Assignee: Tecomet, Inc.
    Inventors: Mark Amrich, Jonathan L. Rolfe, Joseph Buturlia, Robert F. Lynch
  • Publication number: 20030194869
    Abstract: Method for producing a multiplicity of undercut micro recesses in a surface of an article, such that the article exhibits a greater fractal area at a level below the surface than is exhibited at the surface. The method comprises applying a maskant layer to a selected surface of the article, removing the maskant layer in selected loci to expose underlying portions of the article surface in a selected pattern, applying an etchant to the exposed underlying surface portions for a time sufficient to etch the exposed portions of the article and to enable the etchant to etch beneath portions of the remaining maskant layer, and removing the remaining maskant layer to provide the surface in exposed condition with the multiplicity of undercut recesses, to provide an engineered pattern of the recesses.
    Type: Application
    Filed: April 22, 2003
    Publication date: October 16, 2003
    Inventors: Mark P. Amrich, Joseph Buturlia, Robert F. Lynch, Jonathan L. Rolfe
  • Patent number: 6599322
    Abstract: A surgical implant having a datum surface for engaging tissue. Embodiments of the surgical implant include a recess in an original datum surface having a sharp undercut ovoid configuration and a multiplicity of recesses that are interconnected.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: July 29, 2003
    Assignee: Tecomet, Inc.
    Inventors: Mark P. Amrich, Joseph Buturlia, Robert F. Lynch, Jonathan L. Rolfe
  • Publication number: 20030065401
    Abstract: Textured surface having micro recesses such that the outer surface overhangs the micro recesses. Embodiments of the textured surface include sharp edges for promoting bone deposition and growth within the micro recesses, protrusions of varying depth from the surface that include overhangs, and micro recesses that are at least partially defined by complex ellipsoids.
    Type: Application
    Filed: July 24, 2002
    Publication date: April 3, 2003
    Inventors: Mark Amrich, Jonathan L. Rolfe, Joseph Buturlia, Robert F. Lynch
  • Publication number: 20030064115
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Application
    Filed: August 28, 2002
    Publication date: April 3, 2003
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Publication number: 20030062043
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Application
    Filed: August 28, 2002
    Publication date: April 3, 2003
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Publication number: 20030064028
    Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. Precise delivery of nitric oxide at therapeutic levels of 20 to 100 ppm and inhibition of reaction of nitric oxide with oxygen to form toxic impurities such as nitrogen dioxide can provide effective inhalation therapy for pulmonary hypertension.
    Type: Application
    Filed: August 28, 2002
    Publication date: April 3, 2003
    Inventors: David H. Fine, Stephen J. MacDonald, David Rounbehler, David Wheeler, Jonathan L. Rolfe, George Jarvis
  • Publication number: 20020166286
    Abstract: A composition comprising a carrier liquid; a dispersant; and a chemical hydride. The composition can be used in a hydrogen generator to generate hydrogen for use, e.g., as a fuel. A regenerator recovers elemental metal from byproducts of the hydrogen generation process.
    Type: Application
    Filed: January 11, 2002
    Publication date: November 14, 2002
    Inventors: Andrew W. McClaine, Jonathan L. Rolfe, Christopher A. Larsen, Ravi K. Konduri
  • Patent number: 6050990
    Abstract: Methods of applying laser light to the skin, and apparatus therefor, include methods for removing hair, for synchronizing hair growth, for stimulating hair growth, for treating Herpes virus, for reducing sweat and body odor, for in situ formation of a chromophore in hair ducts, for reducing light loss at the skin surface, for grafting of hair stem cells, and for removing keloid or hypertrophic scars. The hair removal methods include controlling the proportions of photomechanical and photothermal damage by selection of laser parameters, chromophore particle size and/or pulse duration, with optional dynamic skin cooling. Additional hair removal methods include infiltrating a photoactivated drug into hair ducts and exposing the skin to sunlight or administering an anti-proliferative agent into hair ducts, for example, by encapsulating the anti-proliferative agent in a slow release vehicle.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: April 18, 2000
    Assignee: ThermoLase Corporation
    Inventors: Nikolai I. Tankovich, Kurt A. Dasse, David H. Fine, Paul W. Fairchild, Zhong-Quan Zhao, Mike Lefebvre, John Lee, Jr., Jonathan L. Rolfe, Susan Murrell, Allen Hunter, II, Amanda J Reynolds, Vladimir G. Kolinko
  • Patent number: 5209786
    Abstract: Disclosed are integrity-enhanced thermoelectric devices and methods of their preparation. Such devices have the following characteristics: (1) there is, on average, no greater than about 10% incidence of function loss (failure) of the device on application to the device of a substantial impact or distortion force or corrosion exposure, and (2) the device have at least about 85% of the thermal performance of thermoelectric devices without integrity enhancement (i.e., thermal conductivity across the integrity-enhanced devices is significantly less than 0.0021 Cal-Cm/Cm.sup.2 Sec .degree.C., and is less than or equal to about 0.0015 Cal-Cm/Cm.sup.2 Sec .degree.C.; empirically expressed as maintenance of at least a 40.degree. C. temperature differential over the intra-plate distance which is about 3/16 to about 1/4 of an inch.).
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: May 11, 1993
    Assignee: Thermo Electron Technologies Corporation
    Inventors: Jonathan L. Rolfe, John S. Beaty
  • Patent number: 5194128
    Abstract: A method for the manufacture of ultrafine particles or atom clusters is disclosed. The ultrafine particles of size between about 10 to 1000 Angstroms are formed by the disruption of the crystal lattice or micrograin structure of the metal, alloy or intermetallic compound in one or both of two spaced electrodes by a high frequency, high voltage, high peak current discharge. The ultrafine particles are not subjected to fractionation as in evaporative processes and accordingly are remarkably predictable in both particle size, distribution of sizes and atomic composition, and also are readily transportable in carrier gases.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: March 16, 1993
    Assignee: Thermo Electron Technologies Corporation
    Inventors: John S. Beaty, Jonathan L. Rolfe
  • Patent number: 5062936
    Abstract: A method for the manufacture of ultrafine particles or atom clusters is disclosed. The ultrafine particles of size between about 10 to 1000 Angstroms are formed by the disruption of the crystal lattice or micrograin structure of the metal, alloy or intermetallic compound in one or both of two spaced electrodes by a high frequency, high voltage, high peak current discharge. The ultrafine particles are not subjected to fractionation as in evaporative processes and accordingly are remarkably predictable in both particle size, distribution of sizes and atomic composition, and also are readily transportable in carrier gases.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: November 5, 1991
    Assignee: Thermo Electron Technologies Corporation
    Inventors: John S. Beaty, Jonathan L. Rolfe
  • Patent number: 4880690
    Abstract: A perfume patch comprising a fragrance-emitting member having a fragrance dispersed within an ultra-thin polyurethane membrane. A layer of pressure sensitive adhesive is applied to adhere the member to a surface. The polyurethane is formed from a diisocyanate, a macroglycol, and an acrylyl chain terminator to which a photoinitiator and a fragrance oil are added prior to curing. A barrier layer may be applied by an adhesive or other suitable means to prevent migration of the fragrance oil to the adhesive so that no residue of adhesive remains on the surface. The perfume patch preferably includes a support for the fragrance-emitting member for ease in application and handling.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: November 14, 1989
    Assignee: Thermedics, Inc.
    Inventors: Michael Szycher, Jonathan L. Rolfe