Abstract: Described herein are compositions comprising, a polymer; a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

Abstract: A delivery adapter which may be used as an interface between a syringe and a catheter hub is described.

Abstract: A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.

Abstract: A delivery adapter which may be used as an interface between a syringe and a catheter hub is described.

Abstract: A system for carrying apparatus for personal use for example portable sound reproduction apparatus, on a limb is disclosed. The system includes a bracelet adapted to fit around a limb of the user, a casing including a cavity shaped and dimensioned to receive the apparatus itself therein, and a cable or lead storage unit including a necked configuration around which one or more cables or leads may be wound for temporary storage. The casing and cable or lead storage unit can each be attached to the bracelet or attached directly to one another. The bracelet may be of slap bracelet construction.

Abstract: Two-part casings are described which have the dual function of enclosing and protecting a hand-held electronic device, for example a music player in one portion of the casing and an accessory to the device such as a battery pack or loudspeaker system. The overall assembled casing is still a hand-held portable unit. A connector (5) inside one portion of the casing may be electrically connected to a connector (6), for example a mini USB socket, for mating with a mini USB plug on the second casing portion which has the accessory located in it.

Abstract: The present invention relates to polypeptides that bind to RANK and comprise amino acid sequences of RANKL external surface loops. The invention also relates to fragments, analogs, and derivatives of such polypeptides.

Abstract: The present invention provides non-naturally occurring proteins that bind to RANK and polynucleotides encoding the same. The proteins of the invention can be used for enhancing bone formation by either inhibiting bone resorption or inducing osteogenesis.

Abstract: Method of screening osteogenic compounds utilizing RANK and/or RANK pathway, compositions comprising compounds selected thereby and method for enhancing bone mass comprising administering to a subject an effective amount of said compositions.

Abstract: The present invention provides crystals of RANKL ectodomain complexes, detailed three dimensional structural information illustrating the interaction between RANKL and RANK and methods of utilizing the X-ray crystallographic data from such crystals and other structural data disclosed to design, identify and screen for compounds that modulate activity. The present invention also relates to machine readable media embedded with the three-dimensional atomic structure coordinates of RANKL crystalline complexes and subsets thereof, together with other structural data disclosed herein.

Abstract: A method of enhancing bone formation comprising administering an effective amount of 1) an oligomeric complex of one or more of RANKL, a RANKL fusion protein or an analog, derivative or mimic thereof, 2) an osteogenic compound capable of enhancing activity of one or more intracellular proteins in osteoblasts or osteoblast precursors, wherein said activity is indicative of bone formation, or 3) an osteogenic compound capable of inactivating one or more phosphatases in osteoblasts or osteoblast precursors, wherein said inactivation is indicative of bone formation. The method also may be used to treat a disease or condition manifested at least in part by the loss of bone mass by administering to a patient a pharmaceutical composition comprising an oligomeric complex or osteogenic compound disclosed herein.