Patents by Inventor Jonathan Lansing
Jonathan Lansing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9182467Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.Type: GrantFiled: April 15, 2008Date of Patent: November 10, 2015Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
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Publication number: 20140127735Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
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Patent number: 8663999Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: GrantFiled: June 8, 2012Date of Patent: March 4, 2014Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Becatti, Scott Bailey, Carlos J. Bosques
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Patent number: 8470603Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: GrantFiled: April 30, 2007Date of Patent: June 25, 2013Assignee: Momenta Pharmaceuticals, Inc.Inventors: Zachary Shriver, Ganesh Venkataraman, Jonathan Lansing, Corinne Bauer, Xiangping Zhu
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Publication number: 20130069645Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: ApplicationFiled: June 8, 2012Publication date: March 21, 2013Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccatti, Scott Bailey, Carlos J. Bosques
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Patent number: 8216851Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: GrantFiled: April 15, 2008Date of Patent: July 10, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
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Patent number: 7968082Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.Type: GrantFiled: January 25, 2008Date of Patent: June 28, 2011Assignee: Momenta Pharmaceuticals, Inc.Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Jonathan Lansing
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Publication number: 20100279269Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.Type: ApplicationFiled: April 15, 2008Publication date: November 4, 2010Applicant: Momenta Pharmaceuticals, Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
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Publication number: 20100188084Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.Type: ApplicationFiled: April 15, 2008Publication date: July 29, 2010Applicant: Momenta Pharmaceuticals,Inc.Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
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Publication number: 20090237078Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: ApplicationFiled: April 30, 2007Publication date: September 24, 2009Inventors: Zachary Shriver, Ganesh Venkataraman, Jonathan Lansing, Corrinne Bauer, Xiaangping Zhu