Abstract: Provided herein are methods and compositions for identifying a targeted genomic insertion in a cell. Also provided are heterologous polypeptides that are co-expressed under the control of enodogenous loci and methods of using same.

Abstract: A text-based real-time communication interface, such as a chatbot, is presented to a user for the exchange of customer support information. A user's freeform text input is analyzed using machine learning algorithms to derive the meaning of the input text as well as to determine the user sentiment expressed therein. These determinations may be further supported by signals extracted from session-based activity, which signals can be used to infer the intended workflow of the user and whether or not that workflow was achieved. The expressed user sentiment is considered along with other historical or session-based user data to generate tailored questions and responses to be delivered in real-time to the user. The responses are displayed to the user along with information that routes the user to a workflow resolution.

Abstract: A preliminary software feature is applied in a testing rollout to a discrete subset of customers. Survey data may be collected from those customers through a variety of sources, such as chatbot text, session workflow, historical user data, social media data, email survey data, user profile data, messaging threads, and the like. This survey data is analyzed using machine learning algorithms to derive the meaning of input text as well as to determine the user sentiment expressed therein. The outputs of this analysis are normalized across sources and aggregated at a feature-level to generate overall metrics of customer satisfaction with the feature. A holistic analysis is performed on this customer sentiment data to obtain an aggregate or combined user satisfaction score. This score is applied against a set of guardrails to determine whether to ship the feature to a broader customer base.

Abstract: A text-based real-time communication interface, such as a chatbot, is presented to a user for the exchange of customer support information. A user's freeform text input is analyzed using machine learning algorithms to derive the meaning of the input text as well as to determine the user sentiment expressed therein. These determinations may be further supported by signals extracted from session-based activity, which signals can be used to infer the intended workflow of the user and whether or not that workflow was achieved. The expressed user sentiment is considered along with other historical or session-based user data to generate tailored questions and responses to be delivered in real-time to the user. The responses are displayed to the user along with information that routes the user to a workflow resolution.

Abstract: The present disclosure is directed toward a system that allows a promotion and marketing system to provide promotions to users of the promotion and marketing system for establishments that are currently not affiliated with the promotion and marketing system.

Abstract: A smart current transformer for determining primary current or power consumption, by stepping down the primary current to a secondary current for subsequent measurement by a connected meter. The current transformer is provided with a connected non-volatile memory for storing calibration data (and optionally identification data) regarding that particular current transformer. The calibration data can include the gain error and/or phase delay for the current transformer, as determined from prior calibration testing of the current transformer. The calibration data may be communicated to or otherwise determined by the meter, and used to calibrate the measurement of the secondary current, in order to determine the primary current or power consumption. Also disclosed is a system and method utilizing such a smart current transformer.

Abstract: Flight based infrared imaging systems and related techniques, and in particular UAS based thermal imaging systems, are provided to improve the monitoring capabilities of such systems over conventional infrared monitoring systems. An infrared imaging system is configured to compensate for various environmental effects (e.g., position and/or strength of the sun, atmospheric effects) to provide high resolution and accuracy radiometric measurements of targets imaged by the infrared imaging system. An infrared imaging system is alternatively configured to monitor and determine environmental conditions, modify data received from infrared imaging systems and other systems, modify flight paths and other commands, and/or create a representation of the environment.

Abstract: The present invention provides synthetic nucleic acid sequences comprising 10-30 nucleotides of the N1 and N2 gene regions and/or the 3? non-coding region of the SARS-associated coronavirus Cov-2 (SARS-CoV-2) genome, and a synthetic nucleic acid sequence comprising 10-30 nucleotides of a nucleic acid sequence that is complementary to at least one of those regions. Also provided are compositions comprising the sequences, and uses of the sequences in diagnostic kits. The present invention further provides a primer and probe set for determining the presence or absence of SARS-associated coronavirus Cov-2 in a biological sample, wherein the primer set comprises at least one of the synthetic nucleic acid sequences. Also provided are a composition comprising the primer and probe set, and use of the primer and probe set in a diagnostic kit. Finally, the present invention provides kits and methods for determining the presence or absence of SARS-associated coronavirus Cov-2 (SARS-CoV-2) in a biological sample.

Abstract: Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic assays (e.g., nucleic acid sequencing based assays and/or nucleic acid amplification based assays).

Abstract: Provided herein are methods and compositions for modifying an endogenous cell surface protein in a human cell by inserting a heterologous nucleic acid sequence in a target region of a nucleic acid encoding the endogenous cell surface protein.

Abstract: Flight based infrared imaging systems and related techniques, and in particular UAS based thermal imaging systems, are provided to improve the monitoring capabilities of such systems over conventional infrared monitoring systems. An infrared imaging system is configured to compensate for various environmental effects (e.g., position and/or strength of the sun, atmospheric effects) to provide high resolution and accuracy radiometric measurements of targets imaged by the infrared imaging system. An infrared imaging system is alternatively configured to monitor and determine environmental conditions, modify data received from infrared imaging systems and other systems, modify flight paths and other commands, and/or create a representation of the environment.

Abstract: A modular load management system comprises one or more compact modules designed to fit in the wiring troughs of a standard AC distribution panel of a building. The modules include one or more input terminals to receive electrical power from one or more circuit breakers in the panel and deliver power to load circuits of the building via one or more output terminals. The modules contain at least one disconnect switch for disconnecting circuits from breakers in response to a remote or locally-generated control signal. The modules may also include current sensors on some or all terminals, such that power and energy flow may be monitored on a per-circuit basis.

Abstract: The present disclosure is directed toward a system that allows a promotion and marketing system to provide promotions to users of the promotion and marketing system for established that are currently not affiliated with the promotion and marketing system.

Abstract: The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a “gpA33×CD3 bi-specific monovalent diabody”). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain (“bi-specific monovalent Fc diabodies”) and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a “gpA33×CD3 bi-specific monovalent Fc diabody”). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies.

Abstract: The present disclosure is directed toward a system that allows a promotion and marketing system to provide promotions to users of the promotion and marketing system for established that are currently not affiliated with the promotion and marketing system.

Abstract: Architecture that generates a companion window in combination with a source application experience to enable the accomplishment of a side task yet not switch away from the context of the source application. The companion window experience is a window that is rendered proximate (e.g., beside) a user's source application experience, in a predictable location, and with a predictable user model for invocation and dismissal. The companion window allows the user to retain full visual context of the associated source application experience, while rendering activities that directly pertain to the source application experience or activities that allow the user to interact with two applications.

Abstract: A process for simultaneously producing treated natural gas and a propane-rich stream from a feed gas comprising methane, ethane and hydrocarbons having more than three carbon atoms.

Abstract: Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic assays (e.g., nucleic acid sequencing based assays and/or nucleic acid amplification based assays).

Abstract: Flight based infrared imaging systems and related techniques, and in particular UAS based thermal imaging systems, are provided to improve the monitoring capabilities of such systems over conventional infrared monitoring systems. An infrared imaging system is configured to compensate for various environmental effects (e.g., position and/or strength of the sun, atmospheric effects) to provide high resolution and accuracy radiometric measurements of targets imaged by the infrared imaging system. An infrared imaging system is alternatively configured to monitor and determine environmental conditions, modify data received from infrared imaging systems and other systems, modify flight paths and other commands, and/or create a representation of the environment.