Patents by Inventor Jonathan Lin
Jonathan Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200126639Abstract: A cell sorting system that automatically generates a sorting strategy based on examples of target events provided by an operator. The target events can be selected using measurements ranging from traditional flow cytometry measurements to derived measurements that are computationally expensive to complex measurements such as images.Type: ApplicationFiled: October 8, 2019Publication date: April 23, 2020Inventors: Jonathan Lin, Joseph Trotter, Keegan Owsley
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Patent number: 10620111Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.Type: GrantFiled: April 11, 2019Date of Patent: April 14, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20200072727Abstract: Non-parametric transforms such as t-distributed stochastic neighbor embedding (tSNE) are used to analyze multi-parametric data such as data derived from flow cytometry or other particle analysis systems and methods. These transforms may be included for dimensionality reduction and identification of subpopulations (e.g., gating). By nature, non-parametric transforms cannot transform new observations without training a new transformation based on the entire dataset including the new observations. The features described parameterize non-parametric transforms using a neural network thereby allowing a small training dataset to be transformed using non-parametric techniques. The training dataset may then be used to generate an accurate parametric model for assessing additional events in a manner consistent with the initial events.Type: ApplicationFiled: August 30, 2019Publication date: March 5, 2020Inventors: Jonathan LIN, Joseph TROTTER, Keegan OWSLEY
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Patent number: 10401988Abstract: The invention relates to a touch screen protector for a hand held electronic device having a front face that includes a touch screen portion and a non-functional band. The touch screen protector of the invention comprises a plastic film having front and back sides, an outer perimeter that corresponds to that of the device, and a transparent window; a spacer provided along the outer perimeter of the plastic film surrounding the transparent window, having a thickness sufficient to space the plastic film near but not in contact with the touch screen portion; an exposed adhesive for removably mounting the protector upon the outer perimeter of the front face to form an enclosed air space between the transparent window of the plastic film, the spacer and the touch screen portion of the device; and a joining adhesive for adhering the spacer to the back side of the plastic film.Type: GrantFiled: November 12, 2013Date of Patent: September 3, 2019Assignee: AEVOE CORP.Inventors: Michael Leonhard, Jonathan Lin, Steven Huang
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Publication number: 20190234863Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.Type: ApplicationFiled: April 11, 2019Publication date: August 1, 2019Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20190204208Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency.Type: ApplicationFiled: March 11, 2019Publication date: July 4, 2019Inventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20190186685Abstract: According to one embodiment, a holder attaches a first electronic device and a second electronic device to a display. The holder includes a base structure, a first holder section, and a second holder section. The first holder section at a first portion of the base structure holds the second electronic device and includes a first through hole that receives a first male screw to be screwed into a first female screw of the first electronic device. The second holder section at a second portion of the base structure holds the second electronic device and includes a second through hole that receives a second male screw to be screwed into a second female screw of the first electronic device.Type: ApplicationFiled: July 18, 2018Publication date: June 20, 2019Inventors: Kenji Yamamori, Masanori Nakano, Brad Chiu, Jonathan Lin, Walter Lin
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Patent number: 10324019Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution. In some embodiments, a single radiofrequency shift is employed to separate the optical frequencies while in other such embodiments a plurality of different radiofrequency shifts are employed.Type: GrantFiled: March 17, 2017Date of Patent: June 18, 2019Assignee: BECTON, DICKINSON AND COMPANYInventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Patent number: 10288546Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency.Type: GrantFiled: August 8, 2018Date of Patent: May 14, 2019Assignee: OMEGA BIOSYSTEMS INCORPORATEDInventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20180348113Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency.Type: ApplicationFiled: August 8, 2018Publication date: December 6, 2018Inventors: Eric D. Diebold, Keegan Owsley, Jonathan Lin
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Patent number: 10078045Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency.Type: GrantFiled: October 13, 2016Date of Patent: September 18, 2018Assignee: OMEGA BIOSYSTEMS INCORPORATEDInventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20180189862Abstract: The invention provides, in some aspects, a digital commerce system that includes a first digital data device, a second digital data device and a third digital data device, each of which is connected to a network that provides at least intermittent communications coupling between the second digital data device and each of the first and second digital data devices. Redirection logic executing on at least the second digital data device effects storage on the third digital data device of a digital media object downloaded from the first digital data device to the second digital data device. The redirection logic accomplishes that in such a manner that storage of the digital media object on the third digital data device is effected before storage of that digital media object on the second digital data device—if the digital media object is stored to the second digital data device at all.Type: ApplicationFiled: February 28, 2018Publication date: July 5, 2018Inventors: Lawrence S. Rogel, John M. Ossenmacher, Jonathan Lin, Xiao Zou
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Publication number: 20170328826Abstract: In one aspect, a system for performing flow cytometry is disclosed, which comprises a laser for generating laser radiation for illuminating a sample, at least one detector for detecting at least a portion of a radiation emanating from the sample in response to said illumination so as to generate a temporal signal corresponding to said detected radiation, and an analysis module for receiving said temporal signal and performing a statistical analysis of said signal based on a forward model to reconstruct an image of said sample.Type: ApplicationFiled: May 12, 2017Publication date: November 16, 2017Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin, Matthew Bahr
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Publication number: 20170268981Abstract: In one aspect, a method of sorting cells in a flow cytometry system is disclosed, which includes illuminating a cell with radiation having at least two optical frequencies shifted from one another by a radiofrequency to elicit fluorescent radiation from the cell, detecting the fluorescent radiation to generate temporal fluorescence data, and processing the temporal fluorescence data to arrive at a sorting decision regarding the cell without generating an image (i.e., a pixel-by-pixel image) of the cell based on the fluorescence data. In other words, while the fluorescence data can contain image data that would allow generating a pixel-by-pixel fluorescence intensity map, the method arrives at the sorting decision without generating such a map. In some cases, the sorting decision can be made with a latency less than about 100 microseconds. In some embodiments, the above method of sorting cells can have a sub-cellular resolution, e.g.Type: ApplicationFiled: March 17, 2017Publication date: September 21, 2017Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Publication number: 20170236190Abstract: The invention provides, in some aspects, a digital commerce system that includes a first digital data device, a second digital data device and a third digital data device, each of which is connected to a network that provides at least intermittent communications coupling between the second digital data device and each of the first and second digital data devices. Redirection logic executing on at least the second digital data device effects storage on the third digital data device of a digital media object downloaded from the first digital data device to the second digital data device. The redirection logic accomplishes that in such a manner that storage of the digital media object on the third digital data device is effected before storage of that digital media object on the second digital data device—if the digital media object is stored to the second digital data device at all.Type: ApplicationFiled: April 21, 2017Publication date: August 17, 2017Applicant: ReDigi, Inc.Inventors: Lawrence S. Rogel, John M. Ossenmacher, Jonathan Lin, Xiao Zou
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Publication number: 20170160828Abstract: The invention relates to a touch screen protector for a hand held electronic device having a front face that includes a touch screen portion and a non-functional band. The touch screen protector of the invention comprises a plastic film having front and back sides, an outer perimeter that corresponds to that of the device, and a transparent window; a spacer provided along the outer perimeter of the plastic film surrounding the transparent window, having a thickness sufficient to space the plastic film near but not in contact with the touch screen portion; an exposed adhesive for removably mounting the protector upon the outer perimeter of the front face to form an enclosed air space between the transparent window of the plastic film, the spacer and the touch screen portion of the device; and a joining adhesive for adhering the spacer to the back side of the plastic film.Type: ApplicationFiled: February 22, 2017Publication date: June 8, 2017Applicant: AEVOE CORPInventors: Michael LEONHARD, Jonathan LIN, Steven HUANG
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Publication number: 20170102314Abstract: In one aspect, the present teachings provide a system for performing cytometry that can be operated in three operational modes. In one operational mode, a fluorescence image of a sample is obtained by exciting one or more fluorophore(s) present in the sample by an excitation beam formed as a superposition of a top-hat-shaped beam with a plurality of beams that are radiofrequency shifted relative to one another. In another operational mode, a sample can be illuminated successively over a time interval by a laser beam at a plurality of excitation frequencies in a scanning fashion. The fluorescence emission from the sample can be detected and analyzed, e.g., to generate a fluorescence image of the sample. In yet another operational mode, the system can be operated to illuminate a plurality of locations of a sample concurrently by a single excitation frequency, which can be generated, e.g., by shifting the central frequency of a laser beam by a radiofrequency.Type: ApplicationFiled: October 13, 2016Publication date: April 13, 2017Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin
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Patent number: 9582040Abstract: The invention relates to a method for protecting a touch screen of a hand held electronic device having a front face that includes a touch screen portion and a non-functional band. The method of the invention comprises providing a touch screen protector comprising a film having front and back sides, an outer perimeter that corresponds to that of the device, and a transparent window; and an exposed adhesive along the outer perimeter of the film surrounding the transparent window; and removably attaching the protector upon the outer perimeter of the front face of the device via the exposed adhesive to form an enclosed air space between the transparent window of the film, the adhesive and the touch screen portion of the device.Type: GrantFiled: March 2, 2012Date of Patent: February 28, 2017Assignee: AEVOE CORP.Inventors: Michael Leonhard, Jonathan Lin, Steven Huang
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Patent number: 9582039Abstract: The invention relates to a touch screen protector for a hand held electronic device having a front face that includes a touch screen portion and a non-functional band. The touch screen protector of the invention comprises a plastic film having front and back sides, an outer perimeter that corresponds to that of the device, and a transparent window; a spacer provided along the outer perimeter of the plastic film surrounding the transparent window, having a thickness sufficient to space the plastic film near but not in contact with the touch screen portion; an exposed adhesive for removably mounting the protector upon the outer perimeter of the front face to form an enclosed air space between the transparent window of the plastic film, the spacer and the touch screen portion of the device; and a joining adhesive for adhering the spacer to the back side of the plastic film.Type: GrantFiled: January 17, 2012Date of Patent: February 28, 2017Assignee: AEVOE CORP.Inventors: Michael Leonhard, Jonathan Lin, Steven Huang
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Publication number: 20160271907Abstract: The invention relates to a touch screen protector for a hand held electronic device having a front face that includes a touch screen portion and a non-functional band. The touch screen protector of the invention comprises a film having front and back sides, an outer perimeter that corresponds to that of the device, and a transparent window; an exposed adhesive or adhesive/spacer provided along the outer perimeter of the film surrounding the transparent window, and multiple dots arranged in a prescribed pitch and present on the back side of the film at a density which is sufficiently high to reduce interference patterns when the transparent window of the protector is pressed against the touch screen portion for operation of the electronic device.Type: ApplicationFiled: March 8, 2016Publication date: September 22, 2016Applicant: AEVOE INTERNATIONAL LTD.Inventors: Michael LEONHARD, Jonathan LIN, Steven HUANG