Abstract: MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGF?, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.

Abstract: MiniVectors and compositions containing MiniVectors that are ultrapure, and methods of making and using ultrapure MiniVectors for gene therapy uses, including long term repeated gene therapy uses.

Abstract: A system for orchestrating deployment of network services is described. The system comprises a plurality of network services, an observability framework and an orchestration agent. The observability framework receives monitoring data corresponding to at least one network function of a network service, identifies data corresponding to the status and/or performance of the network service, aggregates the identified data into genericized metrics for the network service and forwards the genericized metrics to the orchestration agent. The orchestration agent uses the genericized metrics to trigger actions.

Abstract: A system for orchestrating deployment of network services is described. The system comprises a plurality of network services, an observability framework and an orchestration agent. The observability framework receives monitoring data corresponding to at least one network function of a network service, identifies data corresponding to the status and/or performance of the network service, aggregates the identified data into genericized metrics for the network service and forwards the genericized metrics to the orchestration agent. The orchestration agent uses the genericized metrics to trigger actions.

Abstract: Compositions containing MiniVectors and gene therapy uses, including long term repeated gene therapy uses, to treat liver fibrosis or liver cancer.

Abstract: MiniVectors and compositions containing MiniVectors that target ovarian cancer genes selected from FOXM1, AKT, CENPA, PLK1, CDC20, BIRC5, AURKB, CCNB1, CDKN3, BCAM-AKT2, CDKN2D-WDFY2, SLC25A6, CIP2A, CD133, ALDH1A1, CD44, SALL4, and/or PRDM16, alone or in any combination, are provided, along with uses in the treatment of ovarian cancer.

Abstract: A system, method, and apparatus for managing expense reports are disclosed. An example apparatus includes an aggregation interface configured to receive, from a financial entity, a defined account data subset of account data related to a financial transaction of a user and a defined transaction data subset of transaction data of the financial transaction. The example apparatus also includes a secure transaction engine configured to create an expense object that includes the defined account data subset and the defined transaction data subset and display information from the expense object within a first graphical user interface in conjunction with information from other expense objects related to the user. The secure transaction engine is also configured to create an expense report that includes an expense object selected by the user and selectively excludes the other expense objects to shield the other expense objects from being accessible or viewed by a third-party.

Abstract: Minivectors having defined, non-transient shapes as determined by sequence are provided, along with uses in the targeting delivery of such minivectors to target tissues for preferential gene delivery. Method of designing and making shaped minivectors are also provided.

Abstract: Herein is disclosed a ground tile for melting snow and ice. The ground tile includes a flat housing having upper and lower walls and opposite sides, the upper and lower walls and opposite sides defining an interior space. The ground tile also includes first and second electrodes disposed in the interior space, the first and second electrodes being spaced apart accordingly from one another. The interior space is filled with an aqueous glycol solution, the aqueous glycol solution being configured to heat up by electric resistance when an AC current is applied between the first and the second electrodes.

Abstract: A system, method, and apparatus for managing expense reports are disclosed. An example apparatus includes an aggregation interface configured to receive, from a financial entity, a defined account data subset of account data related to a financial transaction of a user and a defined transaction data subset of transaction data of the financial transaction. The example apparatus also includes a secure transaction engine configured to create an expense object that includes the defined account data subset and the defined transaction data subset and display information from the expense object within a first graphical user interface in conjunction with information from other expense objects related to the user. The secure transaction engine is also configured to create an expense report that includes an expense object selected by the user and selectively excludes the other expense objects to shield the other expense objects from being accessible or viewed by a third-party.

Abstract: A method and system is provided that in a fully automated manner generates and stores records regarding online product offerings from a variety of merchants, obtains records relating to a product displayed on a merchant web page, then normalizes and compares the two records to determine whether or not the products they represent are a match. An exemplary method according to the invention is a method for comparing and validating product data. First records that describe a plurality of first products are generated and stored in a database system. Second records that describe a second product are obtained from a web site, and normalized into the same format as the first records. The second records are then compared to the first records to determine whether or not they relate to the same product.

Abstract: A method and system is provided that in a fully automated manner facilitates comparison shopping retail products online. An exemplary method according to the invention is a method for automated comparative shopping. A product for sale by a first merchant that is displayed to a user on a web page is first identified and first records relating to the product are extracted from the web site, including the price of the product and the name of the first merchant. Second records from a database system are retrieved, including the price of the product and the name of the one or more second merchants selling the product, and are formatted into one or more merchant listings, each merchant listing including at least the name of the merchant and the price of the product. The merchant listings are then provided for display to the user.

Abstract: A method and system is provided that in a fully automated manner notifies users of price conditions, including both conditions set by the user and conditions determined to be of interest to the user. An exemplary method according to the invention is a method for online consumer price alerts in which a request is received from the user to notify the user when the price of a product reaches a specific price threshold. The price of the product is monitored on a plurality of merchant web sites, and a notification is provided to the user when the price of the product is at or below the specific price threshold.

Abstract: A method and system is provided that in a fully automated manner identifies a product on a web page as it is displayed on a user's computer, retrieves information regarding the availability of discounts or promotions for that product and notifies the user. An exemplary method according to the invention is a method for identifying and delivering online sales promotions to a user. A product on a web page being displayed on a user's computer is identified, and then information about that available promotions relevant to that product is retrieved from a database system. A notification is then displayed on the user's computer indicating the availability of one or more promotions relevant to the product.

Abstract: A method and apparatus for assigning a unique network address to a first node within a network which is arbitrarily connected. The first node may include a shared network resource, such as a networked printer device, or a modem, in addition to a stand-alone computer system. The network may include a network which is wireless, wherein various nodes comprise radio transceiver circuitry, including radio frequency modems. A first provisional network address for use in assigning the unique network address is determined by the first node. The first node broadcasts probes containing the provisional network address until a first probe response to one of the probes is received or a first interval of time elapses. If the first probe response to one of the probes is received, then the first node determines a second provisional network address and repeats selection of the address and broadcasting, until no probe response is received in the first interval of time.