Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: A process and system for automated online fouling prevention of vertical shell and tube gas-to-gas heat exchangers is provided. The process and system of the invention utilize the flow velocity of the gas within the tubes to facilitate cleaning of the tubes by adding, when necessary, grit to the contaminated gas flow.

Abstract: Methods and systems for reducing electromagnetic interference in analog circuit of a control device for an augmented reality (AR) or virtual reality (VR) system are described. An analog circuit associated with the control device may include at least one amplifier and an analog-to-digital converter coupled to an amplifier by one or more electrical conductors. Electromagnetic interference induced in the one or more electrical conductors by an external AC magnetic field may be reduced using at least one component of the control device configured to reduce the electromagnetic interference.

Abstract: A feedwell is provided for an inclined plate separator having a separation chamber containing parallel plates defining separation passages. The feedwell includes a plenum defining a plenum chamber external to the separation chamber, an upward-facing deflector surface in the plenum chamber, an inlet for discharging influent fluid onto a receiving region of the deflector surface, and an outlet for discharging the influent fluid out of the plenum and transversely into the separation chamber. The feedwell also includes parallel fins. The fins define between them plenum passages that extend from a fin end to outlet. The fin ends are disposed between the outlet and the receiving region, and are arranged in a horizontal semi-elliptical path defining a center that horizontally coincides with the receiving region.

Abstract: Disclosed herein are methods, systems, apparatuses, and media for sensing neuromuscular signals. In one example, a device for sensing neuromuscular signals comprises a wearable structure. The device includes a plurality of signal electrodes aligned along an interior portion of the wearable structure, each signal electrode configured to detect neuromuscular signals. The device further includes a plurality of amplifiers corresponding to the plurality of signal electrodes, wherein an amplifier has: a first input operatively coupled to a corresponding signal electrode; a second input; and an output corresponding to a neuromuscular signal channel. The device further includes circuitry configured to generate a common mode reference signal directly or indirectly based on signals from one or more electrodes, wherein the second input of each amplifier of the plurality of amplifiers is configured to receive the common mode reference signal or a signal based on the common mode reference signal.

Abstract: Techniques for shielding wearable surface electromyography (sEMG) devices are described. According to some aspects, an sEMG device may comprise amplification circuitry comprising at least a first differential amplifier and at least two sEMG electrodes electrically connected to the amplification circuitry. The device may further comprise at least one auxiliary conductor not electrically connected to the amplification circuitry, wherein the at least one auxiliary conductor is configured to be electrically coupled to a wearer of the wearable device, and an electromagnetic shield surrounding the wearable device at least in part and electrically connected to the at least one auxiliary conductor.

Abstract: Arrangements for improving neuromuscular recording electrode contact with a body surface are described. According to some aspects, a sensor assembly may include a housing and one or more electrodes that are moveable relative to the housing. The electrodes may rotate and/or translate relative to the housing and/or have at least two degrees of freedom relative to the housing. The sensor may include a spring element that stores potential energy and biases the electrodes toward a starting position in which the electrodes extend at least partially out of the sensor housing. In some embodiments, application of a contact force to one or more of the electrodes of the sensor compresses the spring element, causing the spring element to store potential energy.

Abstract: Devices for sealing chemical totes and wirelessly monitoring chemicals in the totes include sensors for obtaining data from within the totes and transceivers for receiving and transmitting the data. The data is received from the sensor and transmitted to a gateway transceiver located at a remote location on a low-power wide-area network. Data can be aggregated from multiple devices and relayed to a server on the network. An integrated microcontroller is programmed with instructions for coordinating communications to and from the device transceiver. Systems can include multiple containers located up to 25 miles from one another using the device. Methods including wirelessly monitoring chemicals in chemical totes are disclosed. Data obtained using the device can be used in a variety of ways.

Abstract: Devices for sealing chemical totes and wirelessly monitoring chemicals in the totes include sensors for obtaining data from within the totes and transceivers for receiving and transmitting the data. The data is received from the sensor and transmitted to a gateway transceiver located at a remote location on a low-power wide-area network. Data can be aggregated from multiple devices and relayed to a server on the network. An integrated microcontroller is programmed with instructions for coordinating communications to and from the device transceiver. Systems can include multiple containers located up to 25 miles from one another using the device. Methods including wirelessly monitoring chemicals in chemical totes are disclosed. Data obtained using the device can be used in a variety of ways.

Abstract: Techniques for shielding wearable surface electromyography (sEMG) devices are described. According to some aspects, an sEMG device may comprise amplification circuitry comprising at least a first differential amplifier and at least two sEMG electrodes electrically connected to the amplification circuitry. The device may further comprise at least one auxiliary conductor not electrically connected to the amplification circuitry, wherein the at least one auxiliary conductor is configured to be electrically coupled to a wearer of the wearable device, and an electromagnetic shield surrounding the wearable device at least in part and electrically connected to the at least one auxiliary conductor.

Abstract: Arrangements for improving neuromuscular recording electrode contact with a body surface are described. According to some aspects, a sensor assembly may include a housing and one or more electrodes that are moveable relative to the housing. The electrodes may rotate and/or translate relative to the housing and/or have at least two degrees of freedom relative to the housing. The sensor may include a spring element that stores potential energy and biases the electrodes toward a starting position in which the electrodes extend at least partially out of the sensor housing. In some embodiments, application of a contact force to one or more of the electrodes of the sensor compresses the spring element, causing the spring element to store potential energy.

Abstract: Techniques for shielding wearable surface electromyography (sEMG) devices are described. According to some aspects, an sEMG device may comprise amplification circuitry comprising at least a first differential amplifier and at least two sEMG electrodes electrically connected to the amplification circuitry. The device may further comprise at least one auxiliary conductor not electrically connected to the amplification circuitry, wherein the at least one auxiliary conductor is configured to be electrically coupled to a wearer of the wearable device, and an electromagnetic shield surrounding the wearable device at least in part and electrically connected to the at least one auxiliary conductor.

Abstract: A product may be provided for use with a turbocharging system. A housing may be configured to house a bearing. A shaft may extend through the bearing. A turbine wheel may be connected to one end of the shaft. The housing may include a wall forming an opening and defining a surface facing the opening. The bearing may have a segment extending into the opening and mating with the surface. The wall may include an oil spray groove opening through the surface and having an outlet directed at the shaft.

Abstract: A wearable acupressure device (WAD) is described that may include one or more pockets with one or more beads to apply pressure at various points on the body. The bead may be domed or marble shaped. The WAD may be worn on one or more portions of the body, including the arm, leg, head and foot. Also, the bead may be used for aromatherapy.

Abstract: A product may be provided for use with a turbocharging system. A housing may be configured to house a bearing. A shaft may extend through the bearing. A turbine wheel may be connected to one end of the shaft. The housing may include a wall forming an opening and defining a surface facing the opening. The bearing may have a segment extending into the opening and mating with the surface. The wall may include an oil spray groove opening through the surface and having an outlet directed at the shaft.

Abstract: In some method and apparatus disclosed herein, the profile of current delivered to the substrate provides a relatively uniform current density on the substrate surface during immersion. These methods include controlling the current density applied across a substrate's surface during immersion by dynamically controlling the current to account for the changing substrate surface area in contact with electrolyte during immersion. In some cases, current density pulses and/or steps are used during immersion, as well.

Abstract: An apparatus for electroplating a layer of metal onto the surface of a wafer includes an ionically resistive ionically permeable element located in close proximity of the wafer and an auxiliary cathode located between the anode and the ionically resistive ionically permeable element. The ionically resistive ionically permeable element serves to modulate ionic current at the wafer surface. The auxiliary cathode is configured to shape the current distribution from the anode. The provided configuration effectively redistributes ionic current in the plating system allowing plating of uniform metal layers and mitigating the terminal effect.

Abstract: In a copper electroplating apparatus having separate anolyte and catholyte portions, the concentration of anolyte components (e.g., acid or copper salt) is controlled by providing a diluent to the recirculating anolyte. The dosing of the diluent can be controlled by the user and can follow a pre-determined schedule. For example, the schedule may specify the diluent dosing parameters, so as to prevent precipitation of copper salt in the anolyte. Thus, precipitation-induced anode passivation can be minimized.

Abstract: Apparatus and methods for filling through silicon vias (TSV's) with copper having an intervening tungsten layer between the copper plug and the silicon are disclosed. Methods are useful for Damascene processing, with or without a TSV feature. The tungsten layer serves as a diffusion barrier, a seed layer for copper electrofill and a means of reducing CTE-induced stresses between copper and silicon. Adhesion of the tungsten layer to the silicon and of the copper layer to the tungsten is described.

Abstract: An apparatus for electroplating a layer of metal onto the surface of a wafer includes an ionically resistive ionically permeable element located in close proximity of the wafer and an auxiliary cathode located between the anode and the ionically resistive ionically permeable element. The ionically resistive ionically permeable element serves to modulate ionic current at the wafer surface. The auxiliary cathode is configured to shape the current distribution from the anode. The provided configuration effectively redistributes ionic current in the plating system allowing plating of uniform metal layers and mitigating the terminal effect.