Patents by Inventor Jonathan Sprent

Jonathan Sprent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20130142755
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: June 26, 2012
    Publication date: June 6, 2013
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar
  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20100310501
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: February 16, 2007
    Publication date: December 9, 2010
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar
  • Antigen presenting system and methods for activation of T-cells
    Publication number: 20050152916
    Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
    Type: Application
    Filed: December 7, 2004
    Publication date: July 14, 2005
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per Peterson, Alain Luxembourg, Didier Leturcq, Ann Moriarty
  • Antigen presenting system and methods for activation of T-cells
    Patent number: 6828150
    Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: December 7, 2004
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson, Alain Luxembourg, Didier J. Leturcq, Ann M. Moriarty
  • Antigen presenting system and methods for activation of T-cells
    Publication number: 20030138946
    Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
    Type: Application
    Filed: October 8, 2002
    Publication date: July 24, 2003
    Applicant: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson, Alain Luxembourg, Didier J. Leturcq, Ann M. Moriarty
  • Synthetic antigen presenting matrix
    Publication number: 20030077318
    Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.
    Type: Application
    Filed: March 25, 2002
    Publication date: April 24, 2003
    Applicant: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Antigen presenting system and methods for activation of T-cells
    Publication number: 20030077708
    Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.
    Type: Application
    Filed: March 25, 2002
    Publication date: April 24, 2003
    Applicant: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Synthetic antigen presenting matrix with liposome support
    Publication number: 20030072796
    Abstract: Materials and methods for activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting cell line for activating T lymphocytes to a specific peptide is described.
    Type: Application
    Filed: March 25, 2002
    Publication date: April 17, 2003
    Applicant: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Synthetic antigen presenting matrix
    Patent number: 6461867
    Abstract: Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a synthetic antigen presenting matrix for activating T lymphocytes to a specific peptide is described.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: October 8, 2002
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson, Alain Luxembourg, Didier J. Leturcq, Ann M. Moriarty
  • Method for producing a synthetic antigen presenting transformed Drosophila cell
    Patent number: 6362001
    Abstract: Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting drosophila cell line for activating T lymphocytes to a specific peptide is described.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: March 26, 2002
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Antigen presenting system and methods for activation of T-cells
    Patent number: 6255073
    Abstract: Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, fragments of cells for activating T lymphocytes to a specific peptide are described.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: July 3, 2001
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Antigen presenting system and methods for activation of T-cells
    Patent number: 6251627
    Abstract: The present invention relates to methods for producing synthetic matrix for activating T lymphocytes.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: June 26, 2001
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson
  • Antigen presenting system and methods for activation of T-cells
    Patent number: 6225042
    Abstract: The present invention relates to methods for activating T lymphocytes using a synthetic matrix, and for specifically activating T lymphocytes reactive to a specific peptide.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: May 1, 2001
    Assignee: The Scripps Research Institute
    Inventors: Zeling Cai, Jonathan Sprent, Anders Brunmark, Michael Jackson, Per A. Peterson