Patents by Inventor Jonathan Stuart Wall

Jonathan Stuart Wall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for amyloid removal using anti-amyloid antibodies
    Patent number: 8105594
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: January 31, 2012
    Inventors: Alan Solomon, Rudi Hrncic, Jonathan Stuart Wall
  • METHODS FOR AMYLOID REMOVAL USING ANTI-AMYLOID ANTIBODIES
    Publication number: 20100322932
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Application
    Filed: January 25, 2010
    Publication date: December 23, 2010
    Inventors: Alan Solomon, Rudi Hrncic, Jonathan Stuart Wall
  • Methods of investigating, diagnosing, and treating amyloidosis
    Patent number: 7485616
    Abstract: The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within three weeks for use as a tool to investigate AA amyloidosis and to evaluate agents that may be potentially useful in preventing and treating amyloid-related disorders. Further, the present invention provides diagnostic assays for monitoring immunoglobulin light chain fibrillogenesis in real-time and for identification of the chemical nature of the protein in amyloid deposits which enables the determination of the type of amyloidosis for therapeutic and prognostic purposes.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: February 3, 2009
    Assignee: University of Tennessee Research Foundation
    Inventors: Alan Solomon, Jonathan Stuart Wall, Rudi Hrncic, Maria Schell
  • METHODS FOR AMYLOID REMOVAL USING ANTI-AMYLOID ANTIBODIES
    Publication number: 20030147882
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Application
    Filed: May 21, 1999
    Publication date: August 7, 2003
    Inventors: ALAN SOLOMON, RUDI HRNCIC, JONATHAN STUART WALL
  • Flow cytometric characterization of amyloid fibrils
    Patent number: 6423270
    Abstract: A method of detecting amyloid fibrils in biological samples utilizing flow cytometry is described. It has been found that the measurement of fluorescence from amyloidophilic dyes, such as thioflavin T and Congo red, as well as side scatter and forward scatter measurements are particularly useful in detecting the presence of amyloid fibrils. Flow cytometric detection of amyloid fibrils in subjects such as humans and livestock can be employed for diagnosis, assessment of therapeutic efficacy, research, and monitoring of livestock for the presence of infectious amyloidosis.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: July 23, 2002
    Assignee: University of Tennessee Research Corporation
    Inventor: Jonathan Stuart Wall
  • Methods of investigating, diagnosing, and treating amyloidosis
    Publication number: 20020019335
    Abstract: The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within three weeks for use as a tool to investigate AA amyloidosis and to evaluate agents that may be potentially useful in preventing and treating amyloid-related disorders. Further, the present invention provides diagnostic assays for monitoring immunoglobulin light chain fibrillogenesis in real-time and for identification of the chemical nature of the protein in amyloid deposits which enables the determination of the type of amyloidosis for therapeutic and prognostic purposes.
    Type: Application
    Filed: April 5, 2001
    Publication date: February 14, 2002
    Inventors: Alan Solomon, Jonathan Stuart Wall, Rudi Hrncic, Maria Schell
  • Flow cytometric characterization of amyloid fibrils
    Patent number: 6245572
    Abstract: A method of detecting amyloid fibrils in biological samples utilizing flow cytometry is described. It has been found that the measurement of fluorescence from amyloidophilic dyes, such as thioflavin T and Congo red, as well as side scatter and forward scatter measurements are particularly useful in detecting the presence of amyloid fibrils. Flow cytometric detection of amyloid fibrils in subjects such as humans and livestock can be employed for diagnosis, assessment of therapeutic efficacy, research, and monitoring of livestock for the presence of infectious amyloidosis.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: June 12, 2001
    Assignee: University of Tennessee Research Corporation
    Inventor: Jonathan Stuart Wall