Patents by Inventor Jonathan T.C. Liu
Jonathan T.C. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11885946Abstract: Embodiments disclosed herein directed to multi-direction digital light sheet microscopy (mDSLM). In mDSLM a sample may be illuminated with an illumination sheet which has a first angular diversity along a first axis and a second angular diversity along a second axis which is orthogonal to the first axis. An mDSLM system includes beam shaping optics which may passively reshape light into the illumination sheet. In some embodiments, scanning optics may be used to scan the illumination sheet with respect to the sample. In some embodiments, a confocal aperture may be used to limit out of focus light which reaches a detector of the mDSLM system.Type: GrantFiled: January 25, 2019Date of Patent: January 30, 2024Assignee: University of WashingtonInventors: Adam K. Glaser, Jonathan T. C. Liu
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Patent number: 11803043Abstract: Apparatuses, systems, and methods for dynamically shaped focal surface with a scanning microscope. A microscope (e.g., a scanning confocal microscope) may use a scanning element to scan an illumination beam to generate a focal region. The scanning element may include multiple degrees of freedom, such as rotation and translation along orthogonal axes. For example, if the illumination beam is a line focus, rotation along a first axis and translation along a second orthogonal axis may sweep the line focus across a focal surface which is substantially flat and normal to the second axis. In some embodiments, the microscope may be a dual-axis handheld microscope, where a single objective in a handheld housing is used to both direct the scanned illumination beam and receive the collected light.Type: GrantFiled: December 15, 2020Date of Patent: October 31, 2023Assignee: University of WashingtonInventors: Jonathan T. C. Liu, Lingpeng Wei, Chengbo Yin
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Publication number: 20230341669Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: ApplicationFiled: March 23, 2023Publication date: October 26, 2023Inventors: Adam K. Glaser, Jonathan T.C. Liu
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Patent number: 11644656Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: GrantFiled: May 5, 2022Date of Patent: May 9, 2023Assignee: University of WashingtonInventors: Adam K. Glaser, Jonathan T. C. Liu
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Publication number: 20220326502Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (STMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: ApplicationFiled: February 24, 2022Publication date: October 13, 2022Applicant: University of WashingtonInventors: Jonathan T.C. Liu, Lindsey A. Barner, Adam K. Glaser
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Publication number: 20220260821Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: ApplicationFiled: May 5, 2022Publication date: August 18, 2022Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu
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Patent number: 11287633Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: GrantFiled: June 23, 2021Date of Patent: March 29, 2022Assignee: University of WashingtonInventors: Jonathan T. C. Liu, Lindsey A. Barner, Adam K. Glaser
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Publication number: 20220050280Abstract: Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel.Type: ApplicationFiled: February 12, 2020Publication date: February 17, 2022Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu, Nicholas Reder
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Publication number: 20210325656Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: ApplicationFiled: June 23, 2021Publication date: October 21, 2021Applicant: University of WashingtonInventors: Jonathan T.C. Liu, Lindsey A. Barner, Adam K. Glaser
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Publication number: 20210181490Abstract: Apparatuses, systems, and methods for dynamically shaped focal surface with a scanning microscope. A microscope (e.g., a scanning confocal microscope) may use a scanning element to scan an illumination beam to generate a focal region. The scanning element may include multiple degrees of freedom, such as rotation and translation along orthogonal axes. For example, if the illumination beam is a line focus, rotation along a first axis and translation along a second orthogonal axis may sweep the line focus across a focal surface which is substantially flat and normal to the second axis. In some embodiments, the microscope may be a dual-axis handheld microscope, where a single objective in a handheld housing is used to both direct the scanned illumination beam and receive the collected light.Type: ApplicationFiled: December 15, 2020Publication date: June 17, 2021Inventors: Jonathan T.C. Liu, Lingpeng Wei, Chengbo Yin
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Publication number: 20210033838Abstract: Embodiments disclosed herein directed to multi-direction digital light sheet microscopy (mDSLM). In mDSLM a sample may be illuminated with an illumination sheet which has a first angular diversity along a first axis and a second angular diversity along a second axis which is orthogonal to the first axis. An mDSLM system includes beam shaping optics which may passively reshape light into the illumination sheet. In some embodiments, scanning optics may be used to scan the illumination sheet with respect to the sample. In some embodiments, a confocal aperture may be used to limit out of focus light which reaches a detector of the mDSLM system.Type: ApplicationFiled: January 25, 2019Publication date: February 4, 2021Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu
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Patent number: 9864190Abstract: Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.Type: GrantFiled: February 23, 2012Date of Patent: January 9, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael Mandella, Gordon S. Kino, Christopher H. Contag, Olav Solgaard, Butrus Khuri-Yakub, Omer Oralkan, Jae-Woong Jeong, Paul Cristman, Jonathan T. C. Liu, Hyejun Ra, Jae Eun Hwang
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Publication number: 20120330157Abstract: Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.Type: ApplicationFiled: February 23, 2012Publication date: December 27, 2012Inventors: Michael Mandella, Gordon S. Kino, Christopher H. Contag, Olav Solgaard, Butrus Khuri-Yakub, Omer Oralkan, Jae-Woong Jeong, Paul Cristman, Jonathan T.C. Liu, Hyejun Ra, Jae Eun Hwang