Abstract: Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.

Abstract: Disclosed are a musical instrument stand and a musical instrument stand and musical instrument hanger that are portable and compact. The device has a wide, sturdy base that is capable of holding musical instruments without marring or scratching the finish of the musical instruments. In addition, in accordance with one embodiment, the device can be used as a hanger to hang musical instruments from a wall.

Abstract: Disclosed are a musical instrument stand and a musical instrument stand and musical instrument hanger that are portable and compact. The device has a wide, sturdy base that is capable of holding musical instruments without marring or scratching the finish of the musical instruments. In addition, in accordance with one embodiment, the device can be used as a hanger to hang musical instruments from a wall.

Abstract: Disclosed is a folding sheet music stand that is capable of being folded into a very compact package. In the folded position, the folding sheet music stand is easily transportable and less susceptible to damage. A carrying bag can be used to transport the folded sheet music stand. The folding sheet music stand can be easily assembled and provides a sturdy platform for displaying folded sheet music to musicians. The folding sheet music stand is fully adjustable so that the folding sheet music stand can be used by musicians using various different types of instruments.

Abstract: Disclosed is a folding sheet music stand that is capable of being folded into a very compact package. In the folded position, the folding sheet music stand is easily transportable and less susceptible to damage. A carrying bag can be used to transport the folded sheet music stand. The folding sheet music stand can be easily assembled and provides a sturdy platform for displaying folded sheet music to musicians. The folding sheet music stand is fully adjustable so that the folding sheet music stand can be used by musicians using various different types of instruments.